283 related articles for article (PubMed ID: 16275916)
1. Computational redesign of human butyrylcholinesterase for anticocaine medication.
Pan Y; Gao D; Yang W; Cho H; Yang G; Tai HH; Zhan CG
Proc Natl Acad Sci U S A; 2005 Nov; 102(46):16656-61. PubMed ID: 16275916
[TBL] [Abstract][Full Text] [Related]
2. Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.
Yang W; Xue L; Fang L; Chen X; Zhan CG
Chem Biol Interact; 2010 Sep; 187(1-3):148-52. PubMed ID: 20060817
[TBL] [Abstract][Full Text] [Related]
3. Rational design of an enzyme mutant for anti-cocaine therapeutics.
Zheng F; Zhan CG
J Comput Aided Mol Des; 2008 Sep; 22(9):661-71. PubMed ID: 17989928
[TBL] [Abstract][Full Text] [Related]
4. Human Butyrylcholinesterase Mutants for (-)-Cocaine Hydrolysis: A Correlation Relationship between Catalytic Efficiency and Total Hydrogen Bonding Energy with an Oxyanion Hole.
Zheng F; Hou S; Xue L; Yang W; Zhan CG
J Phys Chem B; 2023 Dec; 127(50):10723-10729. PubMed ID: 38063500
[TBL] [Abstract][Full Text] [Related]
5. Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants.
Pan Y; Gao D; Yang W; Cho H; Zhan CG
J Am Chem Soc; 2007 Nov; 129(44):13537-43. PubMed ID: 17927177
[TBL] [Abstract][Full Text] [Related]
6. Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.
Zheng F; Yang W; Xue L; Hou S; Liu J; Zhan CG
Biochemistry; 2010 Oct; 49(42):9113-9. PubMed ID: 20886866
[TBL] [Abstract][Full Text] [Related]
7. Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine.
Xue L; Hou S; Yang W; Fang L; Zheng F; Zhan CG
Chem Biol Interact; 2013 Mar; 203(1):57-62. PubMed ID: 22917637
[TBL] [Abstract][Full Text] [Related]
8. Substrate selectivity of high-activity mutants of human butyrylcholinesterase.
Hou S; Xue L; Yang W; Fang L; Zheng F; Zhan CG
Org Biomol Chem; 2013 Nov; 11(43):7477-85. PubMed ID: 24077614
[TBL] [Abstract][Full Text] [Related]
9. Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants.
Hamza A; Cho H; Tai HH; Zhan CG
J Phys Chem B; 2005 Mar; 109(10):4776-82. PubMed ID: 16851561
[TBL] [Abstract][Full Text] [Related]
10. Free energy perturbation simulation on transition states and high-activity mutants of human butyrylcholinesterase for (-)-cocaine hydrolysis.
Yang W; Pan Y; Fang L; Gao D; Zheng F; Zhan CG
J Phys Chem B; 2010 Aug; 114(33):10889-96. PubMed ID: 20677742
[TBL] [Abstract][Full Text] [Related]
11. Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine.
Zhan M; Hou S; Zhan CG; Zheng F
Biochem J; 2014 Jan; 457(1):197-206. PubMed ID: 24125115
[TBL] [Abstract][Full Text] [Related]
12. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
Xue L; Ko MC; Tong M; Yang W; Hou S; Fang L; Liu J; Zheng F; Woods JH; Tai HH; Zhan CG
Mol Pharmacol; 2011 Feb; 79(2):290-7. PubMed ID: 20971807
[TBL] [Abstract][Full Text] [Related]
13. Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase.
Gao D; Zhan CG
Proteins; 2006 Jan; 62(1):99-110. PubMed ID: 16288482
[TBL] [Abstract][Full Text] [Related]
14. Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine.
Xue L; Hou S; Tong M; Fang L; Chen X; Jin Z; Tai HH; Zheng F; Zhan CG
Biochem J; 2013 Aug; 453(3):447-54. PubMed ID: 23849058
[TBL] [Abstract][Full Text] [Related]
15. Reaction pathway and free energy profile for prechemical reaction step of human butyrylcholinesterase-catalyzed hydrolysis of (-)-cocaine by combined targeted molecular dynamics and potential of mean force simulations.
Huang X; Pan Y; Zheng F; Zhan CG
J Phys Chem B; 2010 Oct; 114(42):13545-54. PubMed ID: 20883001
[TBL] [Abstract][Full Text] [Related]
16. Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.
Zheng F; Zhan CG
Org Biomol Chem; 2008 Mar; 6(5):836-43. PubMed ID: 18292872
[TBL] [Abstract][Full Text] [Related]
17. Modeling effects of oxyanion hole on the ester hydrolysis catalyzed by human cholinesterases.
Gao D; Zhan CG
J Phys Chem B; 2005 Dec; 109(48):23070-6. PubMed ID: 16854005
[TBL] [Abstract][Full Text] [Related]
18. Free-energy perturbation simulation on transition states and redesign of butyrylcholinesterase.
Yang W; Pan Y; Zheng F; Cho H; Tai HH; Zhan CG
Biophys J; 2009 Mar; 96(5):1931-8. PubMed ID: 19254552
[TBL] [Abstract][Full Text] [Related]
19. Most efficient cocaine hydrolase designed by virtual screening of transition states.
Zheng F; Yang W; Ko MC; Liu J; Cho H; Gao D; Tong M; Tai HH; Woods JH; Zhan CG
J Am Chem Soc; 2008 Sep; 130(36):12148-55. PubMed ID: 18710224
[TBL] [Abstract][Full Text] [Related]
20. Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats.
Chen X; Zheng X; Zhou Z; Zhan CG; Zheng F
Chem Biol Interact; 2016 Nov; 259(Pt B):104-109. PubMed ID: 27154495
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
