These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Molecular mechanisms of resistance to antifolates, a review. Banerjee D; Ercikan-Abali E; Waltham M; Schnieders B; Hochhauser D; Li WW; Fan J; Gorlick R; Goker E; Bertino JR Acta Biochim Pol; 1995; 42(4):457-64. PubMed ID: 8852336 [TBL] [Abstract][Full Text] [Related]
4. Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH. Peñuelas S; Noé V; Morales R; Ciudad CJ Med Sci Monit; 2005 Jan; 11(1):BR6-12. PubMed ID: 15614187 [TBL] [Abstract][Full Text] [Related]
5. Selection for methotrexate resistance in mammalian cells bearing a Drosophila dihydrofolate reductase transgene: Methotrexate resistance in transgenic mammalian cells. Affleck JG; Nowickyj SM; Walker VK Cell Biol Toxicol; 2010 Apr; 26(2):117-26. PubMed ID: 19337845 [TBL] [Abstract][Full Text] [Related]
6. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells. Rhee MS; Galivan J; Wright JE; Rosowsky A Mol Pharmacol; 1994 Apr; 45(4):783-91. PubMed ID: 7514264 [TBL] [Abstract][Full Text] [Related]
7. Suppression of B cell function by methotrexate and trimetrexate. Evidence for inhibition of purine biosynthesis as a major mechanism of action. Rosenthal GJ; Weigand GW; Germolec DR; Blank JA; Luster MI J Immunol; 1988 Jul; 141(2):410-6. PubMed ID: 2968399 [TBL] [Abstract][Full Text] [Related]
8. Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase. Jolivet J; Chabner BA J Clin Invest; 1983 Sep; 72(3):773-8. PubMed ID: 6193143 [TBL] [Abstract][Full Text] [Related]
9. Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. Goldman ID; Matherly LH NCI Monogr; 1987; (5):17-26. PubMed ID: 2448654 [TBL] [Abstract][Full Text] [Related]
10. Regulation of dihydrofolate reductase in human breast cancer cells and in mutant hamster cells transfected with a human dihydrofolate reductase minigene. Cowan KH; Goldsmith ME; Ricciardone MD; Levine R; Rubalcaba E; Jolivet J Mol Pharmacol; 1986 Jul; 30(1):69-76. PubMed ID: 3724746 [TBL] [Abstract][Full Text] [Related]
11. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism. Rosowsky A; Galivan J; Beardsley GP; Bader H; O'Connor BM; Russello O; Moroson BA; DeYarman MT; Kerwar SS; Freisheim JH Cancer Res; 1992 Apr; 52(8):2148-55. PubMed ID: 1313737 [TBL] [Abstract][Full Text] [Related]
12. 5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism. McGuire JJ; Haile WH; Yeh CC Cancer Res; 2006 Apr; 66(7):3836-44. PubMed ID: 16585211 [TBL] [Abstract][Full Text] [Related]
13. Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group. McGuire JJ; Russell CA; Bolanowska WE; Freitag CM; Jones CS; Kalman TI Cancer Res; 1990 Mar; 50(6):1726-31. PubMed ID: 2306727 [TBL] [Abstract][Full Text] [Related]
14. The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate. Fernandes DJ; Moroson BA; Bertino JR Cancer Treat Rep; 1981; 65 Suppl 1():29-35. PubMed ID: 6173121 [TBL] [Abstract][Full Text] [Related]
15. Methotrexate-induced cytotoxicity and genotoxicity in germ cells of mice: intervention of folic and folinic acid. Padmanabhan S; Tripathi DN; Vikram A; Ramarao P; Jena GB Mutat Res; 2009 Feb; 673(1):43-52. PubMed ID: 19110071 [TBL] [Abstract][Full Text] [Related]
16. Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors. Jansen G; Schornagel JH; Westerhof GR; Rijksen G; Newell DR; Jackman AL Cancer Res; 1990 Dec; 50(23):7544-8. PubMed ID: 2253202 [TBL] [Abstract][Full Text] [Related]
17. Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review. Whittle SL; Hughes RA Rheumatology (Oxford); 2004 Mar; 43(3):267-71. PubMed ID: 14963199 [TBL] [Abstract][Full Text] [Related]