230 related articles for article (PubMed ID: 16287261)
1. In vitro system to estimate renal brush border enzyme-mediated cleavage of Peptide linkages for designing radiolabeled antibody fragments of low renal radioactivity levels.
Fujioka Y; Satake S; Uehara T; Mukai T; Akizawa H; Ogawa K; Saji H; Endo K; Arano Y
Bioconjug Chem; 2005; 16(6):1610-6. PubMed ID: 16287261
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis, and evaluation of [188Re]organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels.
Uehara T; Koike M; Nakata H; Hanaoka H; Iida Y; Hashimoto K; Akizawa H; Endo K; Arano Y
Bioconjug Chem; 2007; 18(1):190-8. PubMed ID: 17226973
[TBL] [Abstract][Full Text] [Related]
3. Renal brush border enzyme-cleavable linkages for low renal radioactivity levels of radiolabeled antibody fragments.
Akizawa H; Imajima M; Hanaoka H; Uehara T; Satake S; Arano Y
Bioconjug Chem; 2013 Feb; 24(2):291-9. PubMed ID: 23330714
[TBL] [Abstract][Full Text] [Related]
4. Chemical design of radiolabeled antibody fragments for low renal radioactivity levels.
Arano Y; Fujioka Y; Akizawa H; Ono M; Uehara T; Wakisaka K; Nakayama M; Sakahara H; Konishi J; Saji H
Cancer Res; 1999 Jan; 59(1):128-34. PubMed ID: 9892197
[TBL] [Abstract][Full Text] [Related]
5. Renal metabolism of 3'-iodohippuryl N(epsilon)-maleoyl-L-lysine (HML)-conjugated Fab fragments.
Fujioka Y; Arano Y; Ono M; Uehara T; Ogawa K; Namba S; Saga T; Nakamoto Y; Mukai T; Konishi J; Saji H
Bioconjug Chem; 2001; 12(2):178-85. PubMed ID: 11312678
[TBL] [Abstract][Full Text] [Related]
6. [Design of radiolabeled antibody fragments for tumor-selective radioactivity localization--brush border enzyme-sensitive bond to decrease renal accumulation of radioactivity].
Mukai T; Fujioka Y; Arano Y; Saji H
Yakugaku Zasshi; 2003 Aug; 123(8):647-52. PubMed ID: 12931660
[TBL] [Abstract][Full Text] [Related]
7. A novel radioiodination reagent for protein radiopharmaceuticals with L-lysine as a plasma-stable metabolizable linkage to liberate m-iodohippuric acid after lysosomal proteolysis.
Wakisaka K; Arano Y; Uezono T; Akizawa H; Ono M; Kawai K; Ohomomo Y; Nakayama M; Saji H
J Med Chem; 1997 Aug; 40(16):2643-52. PubMed ID: 9258371
[TBL] [Abstract][Full Text] [Related]
8. Assessment of the radiochemical design of antibodies with a metabolizable linkage for target-selective radioactivity delivery.
Arano Y; Wakisaka K; Akizawa H; Ono M; Kawai K; Nakayama M; Sakahara H; Konishi J; Saji H
Bioconjug Chem; 1998; 9(4):497-506. PubMed ID: 9667952
[TBL] [Abstract][Full Text] [Related]
9. Strategies to reduce renal radioactivity levels of antibody fragments.
Arano Y
Q J Nucl Med; 1998 Dec; 42(4):262-70. PubMed ID: 9973841
[TBL] [Abstract][Full Text] [Related]
10. Assessment of radiochemical design of antibodies using an ester bond as the metabolizable linkage: evaluation of maleimidoethyl 3-(tri-n-butylstannyl)hippurate as a radioiodination reagent of antibodies for diagnostic and therapeutic applications.
Arano Y; Wakisaka K; Ohmono Y; Uezono T; Akizawa H; Nakayama M; Sakahara H; Tanaka C; Konishi J; Yokoyama A
Bioconjug Chem; 1996; 7(6):628-37. PubMed ID: 8950481
[TBL] [Abstract][Full Text] [Related]
11. Preferential Cleavage of a Tripeptide Linkage by Enzymes on Renal Brush Border Membrane To Reduce Renal Radioactivity Levels of Radiolabeled Antibody Fragments.
Suzuki C; Uehara T; Kanazawa N; Wada S; Suzuki H; Arano Y
J Med Chem; 2018 Jun; 61(12):5257-5268. PubMed ID: 29869881
[TBL] [Abstract][Full Text] [Related]
12. Renal Handling of
Uehara T; Kanazawa N; Suzuki C; Mizuno Y; Suzuki H; Hanaoka H; Arano Y
Bioconjug Chem; 2020 Nov; 31(11):2618-2627. PubMed ID: 33085454
[TBL] [Abstract][Full Text] [Related]
13. Reduction of kidney uptake in radiometal labeled peptide linkers conjugated to recombinant antibody fragments. Site-specific conjugation of DOTA-peptides to a Cys-diabody.
Li L; Olafsen T; Anderson AL; Wu A; Raubitschek AA; Shively JE
Bioconjug Chem; 2002; 13(5):985-95. PubMed ID: 12236780
[TBL] [Abstract][Full Text] [Related]
14. Renal tubular processing of small peptide hormones.
Carone FA; Peterson DR; Flouret G
J Lab Clin Med; 1982 Jul; 100(1):1-14. PubMed ID: 7045258
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and preclinical characterization of [64Cu]NODAGA-MAL-exendin-4 with a Nε-maleoyl-L-lysyl-glycine linkage.
Yim CB; Mikkola K; Fagerholm V; Elomaa VV; Ishizu T; Rajander J; Schlesinger J; Roivainen A; Nuutila P; Solin O
Nucl Med Biol; 2013 Nov; 40(8):1006-12. PubMed ID: 23932646
[TBL] [Abstract][Full Text] [Related]
16. Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives.
Behr TM; Sharkey RM; Juweid ME; Blumenthal RD; Dunn RM; Griffiths GL; Bair HJ; Wolf FG; Becker WS; Goldenberg DM
Cancer Res; 1995 Sep; 55(17):3825-34. PubMed ID: 7641200
[TBL] [Abstract][Full Text] [Related]
17. Identification of metabolites of 111In-diethylenetriaminepentaacetic acid-monoclonal antibodies and antibody fragments in vivo.
Rogers BE; Franano FN; Duncan JR; Edwards WB; Anderson CJ; Connett JM; Welch MJ
Cancer Res; 1995 Dec; 55(23 Suppl):5714s-5720s. PubMed ID: 7493333
[TBL] [Abstract][Full Text] [Related]
18. Reduction of the Renal Radioactivity of
Suzuki H; Araki M; Tatsugi K; Ichinohe K; Uehara T; Arano Y
J Med Chem; 2023 Jul; 66(13):8600-8613. PubMed ID: 37322876
[TBL] [Abstract][Full Text] [Related]
19. Renal uptake and metabolism of radiopharmaceuticals derived from peptides and proteins.
Akizawa H; Uehara T; Arano Y
Adv Drug Deliv Rev; 2008 Sep; 60(12):1319-28. PubMed ID: 18508156
[TBL] [Abstract][Full Text] [Related]
20. A Gallium-67/68-Labeled Antibody Fragment for Immuno-SPECT/PET Shows Low Renal Radioactivity Without Loss of Tumor Uptake.
Uehara T; Yokoyama M; Suzuki H; Hanaoka H; Arano Y
Clin Cancer Res; 2018 Jul; 24(14):3309-3316. PubMed ID: 29666303
[No Abstract] [Full Text] [Related]
[Next] [New Search]
