BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 16287996)

  • 1. Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.
    Hay T; Jenkins H; Sansom OJ; Martin NM; Smith GC; Clarke AR
    Cancer Res; 2005 Nov; 65(22):10145-8. PubMed ID: 16287996
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.
    Hay T; Patrick T; Winton D; Sansom OJ; Clarke AR
    Oncogene; 2005 May; 24(23):3842-6. PubMed ID: 15735671
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.
    Smith LM; Willmore E; Austin CA; Curtin NJ
    Clin Cancer Res; 2005 Dec; 11(23):8449-57. PubMed ID: 16322308
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
    Kyle S; Thomas HD; Mitchell J; Curtin NJ
    Br J Radiol; 2008 Oct; 81 Spec No 1():S6-11. PubMed ID: 18820000
    [TBL] [Abstract][Full Text] [Related]  

  • 5. [PARP inhibitors for cancer therapy].
    Saito H; Miki Y
    Gan To Kagaku Ryoho; 2011 Jan; 38(1):12-8. PubMed ID: 21368455
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2.
    Drew Y; Mulligan EA; Vong WT; Thomas HD; Kahn S; Kyle S; Mukhopadhyay A; Los G; Hostomsky Z; Plummer ER; Edmondson RJ; Curtin NJ
    J Natl Cancer Inst; 2011 Feb; 103(4):334-46. PubMed ID: 21183737
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells.
    Vernole P; Muzi A; Volpi A; Dorio AS; Terrinoni A; Shah GM; Graziani G
    Mutat Res; 2009 May; 664(1-2):39-47. PubMed ID: 19428379
    [TBL] [Abstract][Full Text] [Related]  

  • 8. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.
    McCabe N; Lord CJ; Tutt AN; Martin NM; Smith GC; Ashworth A
    Cancer Biol Ther; 2005 Sep; 4(9):934-6. PubMed ID: 16251802
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.
    Evers B; Drost R; Schut E; de Bruin M; van der Burg E; Derksen PW; Holstege H; Liu X; van Drunen E; Beverloo HB; Smith GC; Martin NM; Lau A; O'Connor MJ; Jonkers J
    Clin Cancer Res; 2008 Jun; 14(12):3916-25. PubMed ID: 18559613
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The potential of PARP inhibitors in genetic breast and ovarian cancers.
    Drew Y; Calvert H
    Ann N Y Acad Sci; 2008 Sep; 1138():136-45. PubMed ID: 18837894
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Chromosomal instability syndromes are sensitive to poly ADP-ribose polymerase inhibitors.
    Gaymes TJ; Shall S; Farzaneh F; Mufti GJ
    Haematologica; 2008 Dec; 93(12):1886-9. PubMed ID: 18838476
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The role of poly adenosine diphosphate ribose polymerase inhibitors in breast and ovarian cancer: current status and future directions.
    Chionh F; Mitchell G; Lindeman GJ; Friedlander M; Scott CL
    Asia Pac J Clin Oncol; 2011 Sep; 7(3):197-211. PubMed ID: 21884432
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death.
    Oumouna-Benachour K; Hans CP; Suzuki Y; Naura A; Datta R; Belmadani S; Fallon K; Woods C; Boulares AH
    Circulation; 2007 May; 115(18):2442-50. PubMed ID: 17438151
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.
    Menear KA; Adcock C; Boulter R; Cockcroft XL; Copsey L; Cranston A; Dillon KJ; Drzewiecki J; Garman S; Gomez S; Javaid H; Kerrigan F; Knights C; Lau A; Loh VM; Matthews IT; Moore S; O'Connor MJ; Smith GC; Martin NM
    J Med Chem; 2008 Oct; 51(20):6581-91. PubMed ID: 18800822
    [TBL] [Abstract][Full Text] [Related]  

  • 15. BRCA in breast cancer: from risk assessment to therapeutic prediction.
    Diamond JR; Borges VF; Eckhardt SG; Jimeno A
    Drug News Perspect; 2009 Dec; 22(10):603-8. PubMed ID: 20140280
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
    Bryant HE; Schultz N; Thomas HD; Parker KM; Flower D; Lopez E; Kyle S; Meuth M; Curtin NJ; Helleday T
    Nature; 2005 Apr; 434(7035):913-7. PubMed ID: 15829966
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells.
    Clements KE; Thakar T; Nicolae CM; Liang X; Wang HG; Moldovan GL
    Nucleic Acids Res; 2018 Sep; 46(17):8898-8907. PubMed ID: 30032296
    [TBL] [Abstract][Full Text] [Related]  

  • 18. [Cellular functions of BRCA genes - from basic science to therapeutics].
    Miki Y
    Gan To Kagaku Ryoho; 2012 Apr; 39(4):498-501. PubMed ID: 22504671
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.
    Cheung AM; Hande MP; Jalali F; Tsao MS; Skinnider B; Hirao A; McPherson JP; Karaskova J; Suzuki A; Wakeham A; You-Ten A; Elia A; Squire J; Bristow R; Hakem R; Mak TW
    Cancer Res; 2002 Nov; 62(21):6194-204. PubMed ID: 12414647
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
    Jones P; Altamura S; Boueres J; Ferrigno F; Fonsi M; Giomini C; Lamartina S; Monteagudo E; Ontoria JM; Orsale MV; Palumbi MC; Pesci S; Roscilli G; Scarpelli R; Schultz-Fademrecht C; Toniatti C; Rowley M
    J Med Chem; 2009 Nov; 52(22):7170-85. PubMed ID: 19873981
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.