These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

111 related articles for article (PubMed ID: 16289252)

  • 1. Huntingtin fragmentation and increased caspase 3, 8 and 9 activities in lymphoblasts with heterozygous and homozygous Huntington's disease mutation.
    Maglione V; Cannella M; Gradini R; Cislaghi G; Squitieri F
    Mech Ageing Dev; 2006 Feb; 127(2):213-6. PubMed ID: 16289252
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts.
    Sawa A; Nagata E; Sutcliffe S; Dulloor P; Cascio MB; Ozeki Y; Roy S; Ross CA; Snyder SH
    Neurobiol Dis; 2005 Nov; 20(2):267-74. PubMed ID: 15890517
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
    Wellington CL; Ellerby LM; Gutekunst CA; Rogers D; Warby S; Graham RK; Loubser O; van Raamsdonk J; Singaraja R; Yang YZ; Gafni J; Bredesen D; Hersch SM; Leavitt BR; Roy S; Nicholson DW; Hayden MR
    J Neurosci; 2002 Sep; 22(18):7862-72. PubMed ID: 12223539
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation.
    Squitieri F; Cannella M; Sgarbi G; Maglione V; Falleni A; Lenzi P; Baracca A; Cislaghi G; Saft C; Ragona G; Russo MA; Thompson LM; Solaini G; Fornai F
    Mech Ageing Dev; 2006 Feb; 127(2):217-20. PubMed ID: 16289240
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain.
    Toneff T; Mende-Mueller L; Wu Y; Hwang SR; Bundey R; Thompson LM; Chesselet MF; Hook V
    J Neurochem; 2002 Jul; 82(1):84-92. PubMed ID: 12091468
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Aggregation in Huntington's disease: insights through modelling.
    Cajavec B; Bernard S; Herzel H
    Genome Inform; 2005; 16(1):262-71. PubMed ID: 16362929
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria?
    Sawa A
    J Mol Med (Berl); 2001 Jul; 79(7):375-81. PubMed ID: 11466559
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
    Kim YJ; Yi Y; Sapp E; Wang Y; Cuiffo B; Kegel KB; Qin ZH; Aronin N; DiFiglia M
    Proc Natl Acad Sci U S A; 2001 Oct; 98(22):12784-9. PubMed ID: 11675509
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
    Graham RK; Deng Y; Slow EJ; Haigh B; Bissada N; Lu G; Pearson J; Shehadeh J; Bertram L; Murphy Z; Warby SC; Doty CN; Roy S; Wellington CL; Leavitt BR; Raymond LA; Nicholson DW; Hayden MR
    Cell; 2006 Jun; 125(6):1179-91. PubMed ID: 16777606
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Genotype-, aging-dependent abnormal caspase activity in Huntington disease blood cells.
    Squitieri F; Maglione V; Orobello S; Fornai F
    J Neural Transm (Vienna); 2011 Nov; 118(11):1599-607. PubMed ID: 21519949
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
    Luo S; Vacher C; Davies JE; Rubinsztein DC
    J Cell Biol; 2005 May; 169(4):647-56. PubMed ID: 15911879
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Caspases in Huntington's disease.
    Sanchez Mejia RO; Friedlander RM
    Neuroscientist; 2001 Dec; 7(6):480-9. PubMed ID: 11765125
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Huntingtin processing in pathogenesis of Huntington disease.
    Qin ZH; Gu ZL
    Acta Pharmacol Sin; 2004 Oct; 25(10):1243-9. PubMed ID: 15456523
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dopamine D1 receptor-mediated aggregation of N-terminal fragments of mutant huntingtin and cell death in a neuroblastoma cell line.
    Robinson P; Lebel M; Cyr M
    Neuroscience; 2008 May; 153(3):762-72. PubMed ID: 18403126
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?
    Rangone H; Humbert S; Saudou F
    Pathol Biol (Paris); 2004 Jul; 52(6):338-42. PubMed ID: 15261377
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects.
    Ciammola A; Sassone J; Alberti L; Meola G; Mancinelli E; Russo MA; Squitieri F; Silani V
    Cell Death Differ; 2006 Dec; 13(12):2068-78. PubMed ID: 16729030
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
    Tanaka Y; Igarashi S; Nakamura M; Gafni J; Torcassi C; Schilling G; Crippen D; Wood JD; Sawa A; Jenkins NA; Copeland NG; Borchelt DR; Ross CA; Ellerby LM
    Neurobiol Dis; 2006 Feb; 21(2):381-91. PubMed ID: 16150600
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Huntingtin's critical cleavage.
    Fryer JD; Zoghbi HY
    Nat Neurosci; 2006 Sep; 9(9):1088-9. PubMed ID: 16936769
    [No Abstract]   [Full Text] [Related]  

  • 19. Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.
    Graham RK; Slow EJ; Deng Y; Bissada N; Lu G; Pearson J; Shehadeh J; Leavitt BR; Raymond LA; Hayden MR
    Neurobiol Dis; 2006 Feb; 21(2):444-55. PubMed ID: 16230019
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The role of post-translational modifications of huntingtin in the pathogenesis of Huntington's disease.
    Wang Y; Lin F; Qin ZH
    Neurosci Bull; 2010 Apr; 26(2):153-62. PubMed ID: 20332821
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.