These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 16290143)

  • 1. Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions.
    Shue HJ; Chen X; Schwerdt JH; Paliwal S; Blythin DJ; Lin L; Gu D; Wang C; Reichard GA; Wang H; Piwinski JJ; Duffy RA; Lachowicz JE; Coffin VL; Nomeir AA; Morgan CA; Varty GB; Shih NY
    Bioorg Med Chem Lett; 2006 Feb; 16(4):1065-9. PubMed ID: 16290143
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cyclic urea derivatives as potent NK1 selective antagonists.
    Shue HJ; Chen X; Shih NY; Blythin DJ; Paliwal S; Lin L; Gu D; Schwerdt JH; Shah S; Reichard GA; Piwinski JJ; Duffy RA; Lachowicz JE; Coffin VL; Liu F; Nomeir AA; Morgan CA; Varty GB
    Bioorg Med Chem Lett; 2005 Sep; 15(17):3896-9. PubMed ID: 16019209
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Piperazinyl oxime ethers as NK-1 receptor antagonists.
    van den Hoogenband A; van Maarseveen JH; McCreary AC; Mulder AT; van Scharrenburg GJ; van Stuivenberg HH; Zethof TJ; Zijta B; Iwema Bakker WI
    Bioorg Med Chem Lett; 2006 Feb; 16(4):1045-8. PubMed ID: 16289817
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
    Jacobsen EJ; Stelzer LS; TenBrink RE; Belonga KL; Carter DB; Im HK; Im WB; Sethy VH; Tang AH; VonVoigtlander PF; Petke JD; Zhong WZ; Mickelson JW
    J Med Chem; 1999 Apr; 42(7):1123-44. PubMed ID: 10197957
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models.
    Walpole C; Ko SY; Brown M; Beattie D; Campbell E; Dickenson F; Ewan S; Hughes GA; Lemaire M; Lerpiniere J; Patel S; Urban L
    J Med Chem; 1998 Aug; 41(17):3159-73. PubMed ID: 9703462
    [TBL] [Abstract][Full Text] [Related]  

  • 6. New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABA(A)) receptor. Design, synthesis, biological, and molecular modeling investigation.
    Guerrini G; Ciciani G; Bruni F; Selleri S; Guarino C; Melani F; Montali M; Daniele S; Martini C; Ghelardini C; Norcini M; Ciattini S; Costanzo A
    J Med Chem; 2010 Nov; 53(21):7532-48. PubMed ID: 20939501
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.
    Di Fabio R; Griffante C; Alvaro G; Pentassuglia G; Pizzi DA; Donati D; Rossi T; Guercio G; Mattioli M; Cimarosti Z; Marchioro C; Provera S; Zonzini L; Montanari D; Melotto S; Gerrard PA; Trist DG; Ratti E; Corsi M
    J Med Chem; 2009 May; 52(10):3238-47. PubMed ID: 19388677
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a novel, potent and orally active series of gamma-lactams as selective NK1 antagonists.
    Paliwal S; Reichard GA; Shah S; Wrobleski ML; Wang C; Stengone C; Tsui HC; Xiao D; Duffy RA; Lachowicz JE; Nomeir AA; Varty GB; Shih NY
    Bioorg Med Chem Lett; 2008 Jul; 18(14):4168-71. PubMed ID: 18547807
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cyclobutane derivatives as potent NK1 selective antagonists.
    Wrobleski ML; Reichard GA; Paliwal S; Shah S; Tsui HC; Duffy RA; Lachowicz JE; Morgan CA; Varty GB; Shih NY
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3859-63. PubMed ID: 16682196
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists.
    Ohnmacht CJ; Albert JS; Bernstein PR; Rumsey WL; Masek BB; Dembofsky BT; Koether GM; Andisik DW; Aharony D
    Bioorg Med Chem; 2004 May; 12(10):2653-69. PubMed ID: 15110847
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.
    Drizin I; Gomtsyan A; Bayburt EK; Schmidt RG; Zheng GZ; Perner RJ; DiDomenico S; Koenig JR; Turner SC; Jinkerson TK; Brown BS; Keddy RG; McDonald HA; Honore P; Wismer CT; Marsh KC; Wetter JM; Polakowski JS; Segreti JA; Jarvis MF; Faltynek CR; Lee CH
    Bioorg Med Chem; 2006 Jul; 14(14):4740-9. PubMed ID: 16621571
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1, 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists: determination of the absolute stereochemical requirements.
    Ikeura Y; Ishichi Y; Tanaka T; Fujishima A; Murabayashi M; Kawada M; Ishimaru T; Kamo I; Doi T; Natsugari H
    J Med Chem; 1998 Oct; 41(22):4232-9. PubMed ID: 9784098
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.
    Roppe J; Smith ND; Huang D; Tehrani L; Wang B; Anderson J; Brodkin J; Chung J; Jiang X; King C; Munoz B; Varney MA; Prasit P; Cosford ND
    J Med Chem; 2004 Sep; 47(19):4645-8. PubMed ID: 15341479
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tetrahydroindolizinone NK1 antagonists.
    Bao J; Lu H; Morriello GJ; Carlson EJ; Wheeldon A; Chicchi GG; Kurtz MM; Tsao KL; Zheng S; Tong X; Mills SG; DeVita RJ
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2354-8. PubMed ID: 20188553
    [TBL] [Abstract][Full Text] [Related]  

  • 15. NK1 antagonists based on seven membered lactam scaffolds.
    Elliott JM; Carlson EJ; Chicchi GG; Dirat O; Dominguez M; Gerhard U; Jelley R; Jones AB; Kurtz MM; Tsao Kl; Wheeldon A
    Bioorg Med Chem Lett; 2006 Jun; 16(11):2929-32. PubMed ID: 16574413
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.
    Perner RJ; DiDomenico S; Koenig JR; Gomtsyan A; Bayburt EK; Schmidt RG; Drizin I; Zheng GZ; Turner SC; Jinkerson T; Brown BS; Keddy RG; Lukin K; McDonald HA; Honore P; Mikusa J; Marsh KC; Wetter JM; George KS; Jarvis MF; Faltynek CR; Lee CH
    J Med Chem; 2007 Jul; 50(15):3651-60. PubMed ID: 17583335
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel synthesis and pharmacological evaluation as alpha2-adrenoceptor ligands of O-phenylisouronium salts.
    Goonan A; Kahvedzić A; Rodriguez F; Nagle PS; McCabe T; Rozas I; Erdozain AM; Meana JJ; Callado LF
    Bioorg Med Chem; 2008 Sep; 16(17):8210-7. PubMed ID: 18678494
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New benzoyl urea derivatives as novel NR2B selective NMDA receptor antagonists.
    Borza I; Greiner I; Kolok S; Galgóczy K; Ignácz-Szendrei G; Horváth C; Farkas S; Gáti T; Háda V; Domány G
    Pharmazie; 2006 Sep; 61(9):799-800. PubMed ID: 17020160
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V1A receptor.
    Shimada Y; Taniguchi N; Matsuhisa A; Akane H; Kawano N; Suzuki T; Tobe T; Kakefuda A; Yatsu T; Tahara A; Tomura Y; Kusayama T; Wada K; Tsukada J; Orita M; Tsunoda T; Tanaka A
    Bioorg Med Chem; 2006 Mar; 14(6):1827-37. PubMed ID: 16290163
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists.
    Johnson SG; Gunnet JW; Moore JB; Miller W; Wines P; Rivero RA; Combs D; Demarest KT
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3362-6. PubMed ID: 16650762
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.