BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

79 related articles for article (PubMed ID: 16298244)

  • 1. Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum.
    Uchihara T; Sanjo N; Nakamura A; Han K; Song SY; St George-Hyslop P; Fraser PE
    Neurobiol Aging; 2006 Jan; 27(1):88-97. PubMed ID: 16298244
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
    Edbauer D; Winkler E; Haass C; Steiner H
    Proc Natl Acad Sci U S A; 2002 Jun; 99(13):8666-71. PubMed ID: 12048259
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
    Shiraishi H; Marutani T; Wang HQ; Maeda Y; Kurono Y; Takashima A; Araki W; Nishimura M; Yanagisawa K; Komano H
    Genes Cells; 2006 Jan; 11(1):83-93. PubMed ID: 16371134
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
    Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
    Kaether C; Capell A; Edbauer D; Winkler E; Novak B; Steiner H; Haass C
    EMBO J; 2004 Dec; 23(24):4738-48. PubMed ID: 15549135
    [TBL] [Abstract][Full Text] [Related]  

  • 6. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
    J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle.
    Ilaya NT; Evin G; Masters CL; Culvenor JG
    J Neurochem; 2004 Oct; 91(1):230-7. PubMed ID: 15379903
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury.
    Nadler Y; Alexandrovich A; Grigoriadis N; Hartmann T; Rao KS; Shohami E; Stein R
    Glia; 2008 Apr; 56(5):552-67. PubMed ID: 18240300
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
    Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
    J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
    [TBL] [Abstract][Full Text] [Related]  

  • 10. [3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: relevance to Abeta genesis and presence of active presenilin-1 components.
    Xiong K; Clough RW; Luo XG; Struble RG; Li YM; Yan XX
    Brain Res; 2007 Jul; 1157():81-91. PubMed ID: 17512915
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Neprilysin activity and expression are controlled by nicastrin.
    Pardossi-Piquard R; Dunys J; Yu G; St George-Hyslop P; Alves da Costa C; Checler F
    J Neurochem; 2006 May; 97(4):1052-6. PubMed ID: 16606360
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A; Uemura K; Kitagawa N; Aoyagi N; Kihara T; Ninomiya H; Ishiura S; Takahashi R; Shimohama S
    J Neurosci Res; 2007 Jan; 85(1):153-65. PubMed ID: 17075903
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synaptophysin expression during synaptogenesis in the rat cerebellar cortex.
    Leclerc N; Beesley PW; Brown I; Colonnier M; Gurd JW; Paladino T; Hawkes R
    J Comp Neurol; 1989 Feb; 280(2):197-212. PubMed ID: 2494237
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
    Walker ES; Martinez M; Wang J; Goate A
    J Neurochem; 2006 Jul; 98(1):300-9. PubMed ID: 16805816
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms.
    Oh YS; Turner RJ
    Biochem Biophys Res Commun; 2006 Jul; 346(1):330-4. PubMed ID: 16756946
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
    Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains.
    Kodam A; Vetrivel KS; Thinakaran G; Kar S
    Neurobiol Aging; 2008 May; 29(5):724-38. PubMed ID: 17222950
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Isoform-dependent immunolocalization of 14-3-3 proteins in developing rat cerebellum.
    Umahara T; Uchihara T; Nakamura A; Iwamoto T
    Brain Res; 2009 Feb; 1253():15-26. PubMed ID: 19070608
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Degradation of nicastrin involves both proteasome and lysosome.
    He G; Qing H; Tong Y; Cai F; Ishiura S; Song W
    J Neurochem; 2007 May; 101(4):982-92. PubMed ID: 17326768
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.