These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

86 related articles for article (PubMed ID: 16303300)

  • 1. Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.
    Jones P; Atack JR; Braun MP; Cato BP; Chambers MS; O'Connor D; Cook SM; Hobbs SC; Maxey R; Szekeres HJ; Szeto N; Wafford KA; MacLeod AM
    Bioorg Med Chem Lett; 2006 Feb; 16(4):872-5. PubMed ID: 16303300
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
    Atack JR; Maubach KA; Wafford KA; O'Connor D; Rodrigues AD; Evans DC; Tattersall FD; Chambers MS; MacLeod AM; Eng WS; Ryan C; Hostetler E; Sanabria SM; Gibson RE; Krause S; Burns HD; Hargreaves RJ; Agrawal NG; McKernan RM; Murphy MG; Gingrich K; Dawson GR; Musson DG; Petty KJ
    J Pharmacol Exp Ther; 2009 Nov; 331(2):470-84. PubMed ID: 19704033
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
    Chambers MS; Atack JR; Carling RW; Collinson N; Cook SM; Dawson GR; Ferris P; Hobbs SC; O'connor D; Marshall G; Rycroft W; Macleod AM
    J Med Chem; 2004 Nov; 47(24):5829-32. PubMed ID: 15537339
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aldehyde oxidase and its contribution to the metabolism of a structurally novel, functionally selective GABAA alpha5-subtype inverse agonist.
    O'Connor D; Jones P; Chambers MS; Maxey R; Szekeres HJ; Szeto N; Scott-Stevens P; Macleod AM; Braun M; Cato B
    Xenobiotica; 2006 Apr; 36(4):315-30. PubMed ID: 16684711
    [TBL] [Abstract][Full Text] [Related]  

  • 5. GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
    Atack JR
    Curr Top Med Chem; 2011; 11(9):1203-14. PubMed ID: 21050171
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
    Chambers MS; Atack JR; Broughton HB; Collinson N; Cook S; Dawson GR; Hobbs SC; Marshall G; Maubach KA; Pillai GV; Reeve AJ; MacLeod AM
    J Med Chem; 2003 May; 46(11):2227-40. PubMed ID: 12747794
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
    Jennings AS; Lewis RT; Russell MG; Hallett DJ; Street LJ; Castro JL; Atack JR; Cook SM; Lincoln R; Stanley J; Smith AJ; Reynolds DS; Sohal B; Pike A; Marshall GR; Wafford KA; Sheppard WF; Tye SJ
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1477-80. PubMed ID: 16386900
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
    Street LJ; Sternfeld F; Jelley RA; Reeve AJ; Carling RW; Moore KW; McKernan RM; Sohal B; Cook S; Pike A; Dawson GR; Bromidge FA; Wafford KA; Seabrook GR; Thompson SA; Marshall G; Pillai GV; Castro JL; Atack JR; MacLeod AM
    J Med Chem; 2004 Jul; 47(14):3642-57. PubMed ID: 15214791
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Occupancy of human brain GABA(A) receptors by the novel α5 subtype-selective benzodiazepine site inverse agonist α5IA as measured using [¹¹C]flumazenil PET imaging.
    Eng W; Atack JR; Bergstrom M; Sanabria S; Appel L; Dawson GR; Sciberras D; Hargreaves RJ; Langstrom B; Burns HD
    Neuropharmacology; 2010 Dec; 59(7-8):635-9. PubMed ID: 20696179
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Preclinical and clinical pharmacology of the GABAA receptor alpha5 subtype-selective inverse agonist alpha5IA.
    Atack JR
    Pharmacol Ther; 2010 Jan; 125(1):11-26. PubMed ID: 19770002
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.
    Atack JR; Wong DF; Fryer TD; Ryan C; Sanabria S; Zhou Y; Dannals RF; Eng WS; Gibson RE; Burns HD; Vega JM; Vessy L; Scott-Stevens P; Beech JS; Baron JC; Sohal B; Schrag ML; Aigbirhio FI; McKernan RM; Hargreaves RJ
    J Pharmacol Exp Ther; 2010 Jan; 332(1):17-25. PubMed ID: 19779131
    [TBL] [Abstract][Full Text] [Related]  

  • 12. (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.
    Brehm L; Greenwood JR; Hansen KB; Nielsen B; Egebjerg J; Stensbøl TB; Bräuner-Osborne H; Sløk FA; Kronborg TT; Krogsgaard-Larsen P
    J Med Chem; 2003 Apr; 46(8):1350-8. PubMed ID: 12672235
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4]triazine: synthesis of an alpha 2/3-selective GABA agonist.
    Gauthier DR; Limanto J; Devine PN; Desmond RA; Szumigala RH; Foster BS; Volante RP
    J Org Chem; 2005 Jul; 70(15):5938-45. PubMed ID: 16018689
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists.
    Carling RW; Russell MG; Moore KW; Mitchinson A; Guiblin A; Smith A; Wafford KA; Marshall G; Atack JR; Street LJ
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3550-4. PubMed ID: 16621541
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination.
    Mirza NR; Rodgers RJ; Mathiasen LS
    J Pharmacol Exp Ther; 2006 Mar; 316(3):1291-9. PubMed ID: 16339395
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys.
    Platt DM; Duggan A; Spealman RD; Cook JM; Li X; Yin W; Rowlett JK
    J Pharmacol Exp Ther; 2005 May; 313(2):658-67. PubMed ID: 15650112
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Metabolism of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): identification of an unusual N-acetylglucosamine conjugate in the cynomolgus monkey.
    Johnson BM; Kamath AV; Leet JE; Liu X; Bhide RS; Tejwani RW; Zhang Y; Qian L; Wei DD; Lombardo LJ; Shu YZ
    Drug Metab Dispos; 2008 Dec; 36(12):2475-83. PubMed ID: 18787055
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.
    Gilligan PJ; Clarke T; He L; Lelas S; Li YW; Heman K; Fitzgerald L; Miller K; Zhang G; Marshall A; Krause C; McElroy JF; Ward K; Zeller K; Wong H; Bai S; Saye J; Grossman S; Zaczek R; Arneric SP; Hartig P; Robertson D; Trainor G
    J Med Chem; 2009 May; 52(9):3084-92. PubMed ID: 19361209
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.
    Sternfeld F; Carling RW; Jelley RA; Ladduwahetty T; Merchant KJ; Moore KW; Reeve AJ; Street LJ; O'Connor D; Sohal B; Atack JR; Cook S; Seabrook G; Wafford K; Tattersall FD; Collinson N; Dawson GR; Castro JL; MacLeod AM
    J Med Chem; 2004 Apr; 47(9):2176-9. PubMed ID: 15084116
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.
    Chambers MS; Atack JR; Bromidge FA; Broughton HB; Cook S; Dawson GR; Hobbs SC; Maubach KA; Reeve AJ; Seabrook GR; Wafford K; MacLeod AM
    J Med Chem; 2002 Mar; 45(6):1176-9. PubMed ID: 11881985
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.