168 related articles for article (PubMed ID: 16326815)
1. Selective pathways for the metabolism of phencyclidine by cytochrome p450 2b enzymes: identification of electrophilic metabolites, glutathione, and N-acetyl cysteine adducts.
Shebley M; Jushchyshyn MI; Hollenberg PF
Drug Metab Dispos; 2006 Mar; 34(3):375-83. PubMed ID: 16326815
[TBL] [Abstract][Full Text] [Related]
2. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
[TBL] [Abstract][Full Text] [Related]
3. Mutation of a single residue (K262R) in P450 2B6 leads to loss of mechanism-based inactivation by phencyclidine.
Shebley M; Hollenberg PF
Drug Metab Dispos; 2007 Aug; 35(8):1365-71. PubMed ID: 17460030
[TBL] [Abstract][Full Text] [Related]
4. Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine.
Jushchyshyn MI; Wahlstrom JL; Hollenberg PF; Wienkers LC
Drug Metab Dispos; 2006 Sep; 34(9):1523-9. PubMed ID: 16782764
[TBL] [Abstract][Full Text] [Related]
5. The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.
Jushchyshyn MI; Kent UM; Hollenberg PF
Drug Metab Dispos; 2003 Jan; 31(1):46-52. PubMed ID: 12485952
[TBL] [Abstract][Full Text] [Related]
6. Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
Kent UM; Lin HL; Mills DE; Regal KA; Hollenberg PF
Chem Res Toxicol; 2006 Feb; 19(2):279-87. PubMed ID: 16485904
[TBL] [Abstract][Full Text] [Related]
7. Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites.
Kent UM; Mills DE; Rajnarayanan RV; Alworth WL; Hollenberg PF
J Pharmacol Exp Ther; 2002 Feb; 300(2):549-58. PubMed ID: 11805216
[TBL] [Abstract][Full Text] [Related]
8. Metabolic inactivation of cytochrome P4502B1 by phencyclidine: immunochemical and radiochemical analyses of the protective effects of glutathione.
Sharma U; Roberts ES; Kent UM; Owens SM; Hollenberg PF
Drug Metab Dispos; 1997 Feb; 25(2):243-50. PubMed ID: 9029055
[TBL] [Abstract][Full Text] [Related]
9. Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6.
Kent UM; Sridar C; Spahlinger G; Hollenberg PF
Chem Res Toxicol; 2008 Oct; 21(10):1956-63. PubMed ID: 18729327
[TBL] [Abstract][Full Text] [Related]
10. Metabolism of bergamottin by cytochromes P450 2B6 and 3A5.
Kent UM; Lin HL; Noon KR; Harris DL; Hollenberg PF
J Pharmacol Exp Ther; 2006 Sep; 318(3):992-1005. PubMed ID: 16785317
[TBL] [Abstract][Full Text] [Related]
11. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
Yan Z; Easterwood LM; Maher N; Torres R; Huebert N; Yost GS
Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
[TBL] [Abstract][Full Text] [Related]
12. Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.
Baer BR; Rettie AE; Henne KR
Chem Res Toxicol; 2005 May; 18(5):855-64. PubMed ID: 15892579
[TBL] [Abstract][Full Text] [Related]
13. Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling.
Shebley M; Kent UM; Ballou DP; Hollenberg PF
Drug Metab Dispos; 2009 Apr; 37(4):745-52. PubMed ID: 19144770
[TBL] [Abstract][Full Text] [Related]
14. Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.
Harleton E; Webster M; Bumpus NN; Kent UM; Rae JM; Hollenberg PF
J Pharmacol Exp Ther; 2004 Sep; 310(3):1011-9. PubMed ID: 15121764
[TBL] [Abstract][Full Text] [Related]
15. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.
Chen CS; Lin JT; Goss KA; He YA; Halpert JR; Waxman DJ
Mol Pharmacol; 2004 May; 65(5):1278-85. PubMed ID: 15102956
[TBL] [Abstract][Full Text] [Related]
16. Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6.
Lin HL; Zhang H; Hollenberg PF
J Pharmacol Exp Ther; 2009 Apr; 329(1):26-37. PubMed ID: 19168709
[TBL] [Abstract][Full Text] [Related]
17. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
Lin HL; Kent UM; Hollenberg PF
J Pharmacol Exp Ther; 2005 Apr; 313(1):154-64. PubMed ID: 15608076
[TBL] [Abstract][Full Text] [Related]
18. Phencyclidine iminium ion. NADPH-dependent metabolism, covalent binding to macromolecules, and inactivation of cytochrome(s) P-450.
Hoag MK; Trevor AJ; Kalir A; Castagnoli N
Drug Metab Dispos; 1987; 15(4):485-90. PubMed ID: 2888621
[TBL] [Abstract][Full Text] [Related]
19. Covalent thiol adducts arising from reactive intermediates of cocaine biotransformation.
Schneider KJ; DeCaprio AP
Chem Res Toxicol; 2013 Nov; 26(11):1755-64. PubMed ID: 24112049
[TBL] [Abstract][Full Text] [Related]
20. Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines.
Kobayashi Y; Sridar C; Kent UM; Puppali SG; Rimoldi JM; Zhang H; Waskell L; Hollenberg PF
Drug Metab Dispos; 2006 Dec; 34(12):2102-10. PubMed ID: 16997911
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
