469 related articles for article (PubMed ID: 16336629)
21. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
[TBL] [Abstract][Full Text] [Related]
22. Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.
Patey SJ; Yates EA; Turnbull JE
Biochem Soc Trans; 2005 Nov; 33(Pt 5):1116-8. PubMed ID: 16246059
[TBL] [Abstract][Full Text] [Related]
23. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
Lin HC; Hsieh HM; Chen YH; Hu ML
Neurotoxicology; 2009 Jul; 30(4):622-7. PubMed ID: 19635394
[TBL] [Abstract][Full Text] [Related]
24. Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide].
Best JD; Jay MT; Otu F; Ma J; Nadin A; Ellis S; Lewis HD; Pattison C; Reilly M; Harrison T; Shearman MS; Williamson TL; Atack JR
J Pharmacol Exp Ther; 2005 May; 313(2):902-8. PubMed ID: 15743924
[TBL] [Abstract][Full Text] [Related]
25. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.
Yu WH; Kumar A; Peterhoff C; Shapiro Kulnane L; Uchiyama Y; Lamb BT; Cuervo AM; Nixon RA
Int J Biochem Cell Biol; 2004 Dec; 36(12):2531-40. PubMed ID: 15325590
[TBL] [Abstract][Full Text] [Related]
26. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
[TBL] [Abstract][Full Text] [Related]
27. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
Hook VY; Reisine TD
J Neurosci Res; 2003 Nov; 74(3):393-405. PubMed ID: 14598316
[TBL] [Abstract][Full Text] [Related]
28. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
Ohno M; Chang L; Tseng W; Oakley H; Citron M; Klein WL; Vassar R; Disterhoft JF
Eur J Neurosci; 2006 Jan; 23(1):251-60. PubMed ID: 16420434
[TBL] [Abstract][Full Text] [Related]
29. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
Lewis HD; Pérez Revuelta BI; Nadin A; Neduvelil JG; Harrison T; Pollack SJ; Shearman MS
Biochemistry; 2003 Jun; 42(24):7580-6. PubMed ID: 12809514
[TBL] [Abstract][Full Text] [Related]
30. Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse.
Hyde LA; McHugh NA; Chen J; Zhang Q; Manfra D; Nomeir AA; Josien H; Bara T; Clader JW; Zhang L; Parker EM; Higgins GA
J Pharmacol Exp Ther; 2006 Dec; 319(3):1133-43. PubMed ID: 16946102
[TBL] [Abstract][Full Text] [Related]
31. Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling.
Shimazawa M; Inokuchi Y; Okuno T; Nakajima Y; Sakaguchi G; Kato A; Oku H; Sugiyama T; Kudo T; Ikeda T; Takeda M; Hara H
J Neurochem; 2008 Oct; 107(1):279-90. PubMed ID: 18691390
[TBL] [Abstract][Full Text] [Related]
32. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
Irizarry MC; Deng A; Lleo A; Berezovska O; Von Arnim CA; Martin-Rehrmann M; Manelli A; LaDu MJ; Hyman BT; Rebeck GW
J Neurochem; 2004 Sep; 90(5):1132-43. PubMed ID: 15312168
[TBL] [Abstract][Full Text] [Related]
33. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.
Parvathy S; Ehrlich M; Pedrini S; Diaz N; Refolo L; Buxbaum JD; Bogush A; Petanceska S; Gandy S
J Neurochem; 2004 Aug; 90(4):1005-10. PubMed ID: 15287907
[TBL] [Abstract][Full Text] [Related]
34. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
Lefranc-Jullien S; Sunyach C; Checler F
J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
[TBL] [Abstract][Full Text] [Related]
35. 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.
Zhu Z; Li C; Wang X; Yang Z; Chen J; Hu L; Jiang H; Shen X
J Neurochem; 2010 Jul; 114(2):374-85. PubMed ID: 20412384
[TBL] [Abstract][Full Text] [Related]
36. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA
Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868
[TBL] [Abstract][Full Text] [Related]
37. Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.
Volbracht C; Penzkofer S; Mansson D; Christensen KV; Fog K; Schildknecht S; Leist M; Nielsen J
Anal Biochem; 2009 Apr; 387(2):208-20. PubMed ID: 19454261
[TBL] [Abstract][Full Text] [Related]
38. Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.
Hartlage-Rübsamen M; Zeitschel U; Apelt J; Gärtner U; Franke H; Stahl T; Günther A; Schliebs R; Penkowa M; Bigl V; Rossner S
Glia; 2003 Jan; 41(2):169-79. PubMed ID: 12509807
[TBL] [Abstract][Full Text] [Related]
39. Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.
Johnston JA; Liu WW; Todd SA; Coulson DT; Murphy S; Irvine GB; Passmore AP
Biochem Soc Trans; 2005 Nov; 33(Pt 5):1096-100. PubMed ID: 16246054
[TBL] [Abstract][Full Text] [Related]
40. Effects of peptides derived from BACE1 catalytic domain on APP processing.
Yeon SW; Jeon YJ; Hwang EM; Kim TY
Peptides; 2007 Apr; 28(4):838-44. PubMed ID: 17293005
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]