BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

368 related articles for article (PubMed ID: 16339391)

  • 1. Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily.
    Steckelbroeck S; Oyesanmi B; Jin Y; Lee SH; Kloosterboer HJ; Penning TM
    J Pharmacol Exp Ther; 2006 Mar; 316(3):1300-9. PubMed ID: 16339391
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.
    Steckelbroeck S; Jin Y; Oyesanmi B; Kloosterboer HJ; Penning TM
    Mol Pharmacol; 2004 Dec; 66(6):1702-11. PubMed ID: 15383625
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.
    Steckelbroeck S; Jin Y; Gopishetty S; Oyesanmi B; Penning TM
    J Biol Chem; 2004 Mar; 279(11):10784-95. PubMed ID: 14672942
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bioequivalence studies of tibolone in premenopausal women and effects on expression of the tibolone-metabolizing enzyme AKR1C (aldo-keto reductase) family caused by estradiol.
    Kang KW; Kim YG
    J Clin Pharmacol; 2008 Dec; 48(12):1430-7. PubMed ID: 18832293
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators.
    Endo S; Morikawa Y; Matsunaga T; Hara A; Nishinaka T
    J Steroid Biochem Mol Biol; 2022 Jul; 221():106113. PubMed ID: 35398259
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily.
    Jin Y; Duan L; Chen M; Penning TM; Kloosterboer HJ
    J Steroid Biochem Mol Biol; 2012 Apr; 129(3-5):139-44. PubMed ID: 22210085
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.
    Penning TM; Burczynski ME; Jez JM; Hung CF; Lin HK; Ma H; Moore M; Palackal N; Ratnam K
    Biochem J; 2000 Oct; 351(Pt 1):67-77. PubMed ID: 10998348
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.
    Jin Y; Mesaros AC; Blair IA; Penning TM
    Biochem J; 2011 Jul; 437(1):53-61. PubMed ID: 21521174
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C
    Endo S; Morikawa Y; Kudo Y; Suenami K; Matsunaga T; Ikari A; Hara A
    J Steroid Biochem Mol Biol; 2020 May; 199():105586. PubMed ID: 31926269
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.
    Hevir N; Vouk K; Sinkovec J; Ribič-Pucelj M; Rižner TL
    Chem Biol Interact; 2011 May; 191(1-3):217-26. PubMed ID: 21232532
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C3) in the extrahepatic metabolism of the steroidal aromatase inactivator Formestane.
    Wan R; Kong X; Yang Y; Tao S; Chen Y; Teichmann AT; Wieland FH
    J Steroid Biochem Mol Biol; 2020 Apr; 198():105527. PubMed ID: 31733346
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men.
    Blouin K; Richard C; Brochu G; Hould FS; Lebel S; Marceau S; Biron S; Luu-The V; Tchernof A
    J Endocrinol; 2006 Dec; 191(3):637-49. PubMed ID: 17170221
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.
    Penning TM; Jin Y; Heredia VV; Lewis M
    J Steroid Biochem Mol Biol; 2003 Jun; 85(2-5):247-55. PubMed ID: 12943710
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.
    Rizner TL; Lin HK; Peehl DM; Steckelbroeck S; Bauman DR; Penning TM
    Endocrinology; 2003 Jul; 144(7):2922-32. PubMed ID: 12810547
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol.
    Atalla A; Breyer-Pfaff U; Maser E
    Xenobiotica; 2000 Aug; 30(8):755-69. PubMed ID: 11037109
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate.
    Lin HK; Steckelbroeck S; Fung KM; Jones AN; Penning TM
    Steroids; 2004 Dec; 69(13-14):795-801. PubMed ID: 15582534
    [TBL] [Abstract][Full Text] [Related]  

  • 17. An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies.
    Byrns MC; Steckelbroeck S; Penning TM
    Biochem Pharmacol; 2008 Jan; 75(2):484-93. PubMed ID: 17950253
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.
    Ruiz FX; Porté S; Gallego O; Moro A; Ardèvol A; Del Río-Espínola A; Rovira C; Farrés J; Parés X
    Biochem J; 2011 Dec; 440(3):335-44. PubMed ID: 21851338
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.
    Jin Y; Duan L; Lee SH; Kloosterboer HJ; Blair IA; Penning TM
    J Biol Chem; 2009 Apr; 284(15):10013-22. PubMed ID: 19218247
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro metabolism and identification of human enzymes involved in the metabolism of methylnaltrexone.
    Tong Z; Chandrasekaran A; Li H; Rotshteyn Y; Erve JC; Demaio W; Talaat R; Hultin T; Scatina J
    Drug Metab Dispos; 2010 May; 38(5):801-7. PubMed ID: 20173089
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.