264 related articles for article (PubMed ID: 16352597)
21. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
Smith G; Modi S; Pillai I; Lian LY; Sutcliffe MJ; Pritchard MP; Friedberg T; Roberts GC; Wolf CR
Biochem J; 1998 May; 331 ( Pt 3)(Pt 3):783-92. PubMed ID: 9560305
[TBL] [Abstract][Full Text] [Related]
22. Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding.
Wang A; Stout CD; Zhang Q; Johnson EF
J Biol Chem; 2015 Feb; 290(8):5092-5104. PubMed ID: 25555909
[TBL] [Abstract][Full Text] [Related]
23. Structure-based site of metabolism prediction for cytochrome P450 2D6.
Moors SL; Vos AM; Cummings MD; Van Vlijmen H; Ceulemans A
J Med Chem; 2011 Sep; 54(17):6098-105. PubMed ID: 21797232
[TBL] [Abstract][Full Text] [Related]
24. Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
Forouhar F; Hussain M; Farid R; Benach J; Abashidze M; Edstrom WC; Vorobiev SM; Xiao R; Acton TB; Fu Z; Kim JJ; Miziorko HM; Montelione GT; Hunt JF
J Biol Chem; 2006 Mar; 281(11):7533-45. PubMed ID: 16330546
[TBL] [Abstract][Full Text] [Related]
25. The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent.
Lussenburg BM; Keizers PH; de Graaf C; Hidestrand M; Ingelman-Sundberg M; Vermeulen NP; Commandeur JN
Biochem Pharmacol; 2005 Oct; 70(8):1253-61. PubMed ID: 16135359
[TBL] [Abstract][Full Text] [Related]
26. Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studies.
Lee DS; Yamada A; Sugimoto H; Matsunaga I; Ogura H; Ichihara K; Adachi S; Park SY; Shiro Y
J Biol Chem; 2003 Mar; 278(11):9761-7. PubMed ID: 12519760
[TBL] [Abstract][Full Text] [Related]
27. Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase.
Norman DP; Chung SJ; Verdine GL
Biochemistry; 2003 Feb; 42(6):1564-72. PubMed ID: 12578369
[TBL] [Abstract][Full Text] [Related]
28. Crystal structure of a family 54 alpha-L-arabinofuranosidase reveals a novel carbohydrate-binding module that can bind arabinose.
Miyanaga A; Koseki T; Matsuzawa H; Wakagi T; Shoun H; Fushinobu S
J Biol Chem; 2004 Oct; 279(43):44907-14. PubMed ID: 15292273
[TBL] [Abstract][Full Text] [Related]
29. The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid.
Sundaramoorthy M; Terner J; Poulos TL
Structure; 1995 Dec; 3(12):1367-77. PubMed ID: 8747463
[TBL] [Abstract][Full Text] [Related]
30. Identification of critical residues of choline kinase A2 from Caenorhabditis elegans.
Yuan C; Kent C
J Biol Chem; 2004 Apr; 279(17):17801-9. PubMed ID: 14960577
[TBL] [Abstract][Full Text] [Related]
31. Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.
Ellis SW; Hayhurst GP; Smith G; Lightfoot T; Wong MM; Simula AP; Ackland MJ; Sternberg MJ; Lennard MS; Tucker GT
J Biol Chem; 1995 Dec; 270(49):29055-8. PubMed ID: 7493924
[TBL] [Abstract][Full Text] [Related]
32. Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid.
Melet A; Assrir N; Jean P; Pilar Lopez-Garcia M; Marques-Soares C; Jaouen M; Dansette PM; Sari MA; Mansuy D
Arch Biochem Biophys; 2003 Jan; 409(1):80-91. PubMed ID: 12464247
[TBL] [Abstract][Full Text] [Related]
33. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: allosteric effects of NADPH-cytochrome P450 reductase.
Modi S; Gilham DE; Sutcliffe MJ; Lian LY; Primrose WU; Wolf CR; Roberts GC
Biochemistry; 1997 Apr; 36(15):4461-70. PubMed ID: 9109653
[TBL] [Abstract][Full Text] [Related]
34. Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
Lewis DF
Arch Biochem Biophys; 2003 Jan; 409(1):32-44. PubMed ID: 12464242
[TBL] [Abstract][Full Text] [Related]
35. A molecular model of CYP2D6 constructed by homology with the CYP2C5 crystallographic template: investigation of enzyme-substrate interactions.
Lewis DF; Dickins M; Lake BG; Goldfarb PS
Drug Metabol Drug Interact; 2003; 19(3):189-210. PubMed ID: 14682610
[TBL] [Abstract][Full Text] [Related]
36. Topological role of cytochrome P450 2D6 active site residues.
van Waterschoot RA; Keizers PH; de Graaf C; Vermeulen NP; Tschirret-Guth RA
Arch Biochem Biophys; 2006 Mar; 447(1):53-8. PubMed ID: 16466686
[TBL] [Abstract][Full Text] [Related]
37. Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations.
Hendrychová T; Anzenbacherová E; Hudeček J; Skopalík J; Lange R; Hildebrandt P; Otyepka M; Anzenbacher P
Biochim Biophys Acta; 2011 Jan; 1814(1):58-68. PubMed ID: 20656072
[TBL] [Abstract][Full Text] [Related]
38. Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution.
Hasemann CA; Ravichandran KG; Peterson JA; Deisenhofer J
J Mol Biol; 1994 Mar; 236(4):1169-85. PubMed ID: 8120894
[TBL] [Abstract][Full Text] [Related]
39. Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
Flanagan JU; Maréchal JD; Ward R; Kemp CA; McLaughlin LA; Sutcliffe MJ; Roberts GC; Paine MJ; Wolf CR
Biochem J; 2004 Jun; 380(Pt 2):353-60. PubMed ID: 14992686
[TBL] [Abstract][Full Text] [Related]
40. Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism.
Lewis DF; Eddershaw PJ; Goldfarb PS; Tarbit MH
Xenobiotica; 1997 Apr; 27(4):319-39. PubMed ID: 9149373
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
