These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

506 related articles for article (PubMed ID: 16368705)

  • 1. Rapamycin alleviates toxicity of different aggregate-prone proteins.
    Berger Z; Ravikumar B; Menzies FM; Oroz LG; Underwood BR; Pangalos MN; Schmitt I; Wullner U; Evert BO; O'Kane CJ; Rubinsztein DC
    Hum Mol Genet; 2006 Feb; 15(3):433-42. PubMed ID: 16368705
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rapamycin pre-treatment protects against apoptosis.
    Ravikumar B; Berger Z; Vacher C; O'Kane CJ; Rubinsztein DC
    Hum Mol Genet; 2006 Apr; 15(7):1209-16. PubMed ID: 16497721
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.
    Sarkar S; Krishna G; Imarisio S; Saiki S; O'Kane CJ; Rubinsztein DC
    Hum Mol Genet; 2008 Jan; 17(2):170-8. PubMed ID: 17921520
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.
    Williams A; Jahreiss L; Sarkar S; Saiki S; Menzies FM; Ravikumar B; Rubinsztein DC
    Curr Top Dev Biol; 2006; 76():89-101. PubMed ID: 17118264
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
    Sarkar S; Ravikumar B; Floto RA; Rubinsztein DC
    Cell Death Differ; 2009 Jan; 16(1):46-56. PubMed ID: 18636076
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion.
    Berger Z; Davies JE; Luo S; Pasco MY; Majoul I; O'Kane CJ; Rubinsztein DC
    Hum Mol Genet; 2006 Feb; 15(3):453-65. PubMed ID: 16371423
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
    Ravikumar B; Vacher C; Berger Z; Davies JE; Luo S; Oroz LG; Scaravilli F; Easton DF; Duden R; O'Kane CJ; Rubinsztein DC
    Nat Genet; 2004 Jun; 36(6):585-95. PubMed ID: 15146184
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.
    Ravikumar B; Duden R; Rubinsztein DC
    Hum Mol Genet; 2002 May; 11(9):1107-17. PubMed ID: 11978769
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.
    Floto RA; Sarkar S; Perlstein EO; Kampmann B; Schreiber SL; Rubinsztein DC
    Autophagy; 2007; 3(6):620-2. PubMed ID: 17786022
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis.
    King MA; Hands S; Hafiz F; Mizushima N; Tolkovsky AM; Wyttenbach A
    Mol Pharmacol; 2008 Apr; 73(4):1052-63. PubMed ID: 18199701
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Polyalanine and polyserine frameshift products in Huntington's disease.
    Davies JE; Rubinsztein DC
    J Med Genet; 2006 Nov; 43(11):893-6. PubMed ID: 16801344
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.
    Ravikumar B; Imarisio S; Sarkar S; O'Kane CJ; Rubinsztein DC
    J Cell Sci; 2008 May; 121(Pt 10):1649-60. PubMed ID: 18430781
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
    Sarkar S; Davies JE; Huang Z; Tunnacliffe A; Rubinsztein DC
    J Biol Chem; 2007 Feb; 282(8):5641-52. PubMed ID: 17182613
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.
    Sang TK; Li C; Liu W; Rodriguez A; Abrams JM; Zipursky SL; Jackson GR
    Hum Mol Genet; 2005 Feb; 14(3):357-72. PubMed ID: 15590702
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Wild type Huntingtin reduces the cellular toxicity of mutant Huntingtin in mammalian cell models of Huntington's disease.
    Ho LW; Brown R; Maxwell M; Wyttenbach A; Rubinsztein DC
    J Med Genet; 2001 Jul; 38(7):450-2. PubMed ID: 11432963
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Clearance of mutant aggregate-prone proteins by autophagy.
    Ravikumar B; Sarkar S; Rubinsztein DC
    Methods Mol Biol; 2008; 445():195-211. PubMed ID: 18425452
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?
    Ravikumar B; Rubinsztein DC
    Mol Aspects Med; 2006; 27(5-6):520-7. PubMed ID: 16973207
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Huntington's disease: degradation of mutant huntingtin by autophagy.
    Sarkar S; Rubinsztein DC
    FEBS J; 2008 Sep; 275(17):4263-70. PubMed ID: 18637946
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.
    Daldin M; Fodale V; Cariulo C; Azzollini L; Verani M; Martufi P; Spiezia MC; Deguire SM; Cherubini M; Macdonald D; Weiss A; Bresciani A; Vonsattel JG; Petricca L; Marsh JL; Gines S; Santimone I; Marano M; Lashuel HA; Squitieri F; Caricasole A
    Sci Rep; 2017 Jul; 7(1):5070. PubMed ID: 28698602
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Polyglutamine tracts regulate beclin 1-dependent autophagy.
    Ashkenazi A; Bento CF; Ricketts T; Vicinanza M; Siddiqi F; Pavel M; Squitieri F; Hardenberg MC; Imarisio S; Menzies FM; Rubinsztein DC
    Nature; 2017 May; 545(7652):108-111. PubMed ID: 28445460
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.