475 related articles for article (PubMed ID: 16373689)
1. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.
Ii M; Matsunaga N; Hazeki K; Nakamura K; Takashima K; Seya T; Hazeki O; Kitazaki T; Iizawa Y
Mol Pharmacol; 2006 Apr; 69(4):1288-95. PubMed ID: 16373689
[TBL] [Abstract][Full Text] [Related]
2. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate.
Yamada M; Ichikawa T; Ii M; Sunamoto M; Itoh K; Tamura N; Kitazaki T
J Med Chem; 2005 Nov; 48(23):7457-67. PubMed ID: 16279805
[TBL] [Abstract][Full Text] [Related]
3. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.
Matsunaga N; Tsuchimori N; Matsumoto T; Ii M
Mol Pharmacol; 2011 Jan; 79(1):34-41. PubMed ID: 20881006
[TBL] [Abstract][Full Text] [Related]
4. Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model.
Sha T; Sunamoto M; Kitazaki T; Sato J; Ii M; Iizawa Y
Eur J Pharmacol; 2007 Oct; 571(2-3):231-9. PubMed ID: 17632100
[TBL] [Abstract][Full Text] [Related]
5. Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells.
Hirata N; Yanagawa Y; Ebihara T; Seya T; Uematsu S; Akira S; Hayashi F; Iwabuchi K; Onoé K
Mol Immunol; 2008 May; 45(10):2734-42. PubMed ID: 18372043
[TBL] [Abstract][Full Text] [Related]
6. Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation.
Wu GJ; Chen TL; Ueng YF; Chen RM
Toxicol Appl Pharmacol; 2008 Apr; 228(1):105-13. PubMed ID: 18191973
[TBL] [Abstract][Full Text] [Related]
7. Novel synthetic gluco-disaccharide RSCL-0409--a lipopolysaccharide-induced Toll-like receptor-mediated signalling antagonist.
Kalluri MD; Datla P; Bellary A; Basha K; Sharma A; Sharma A; Singh S; Upadhyay S; Rajagopal V
FEBS J; 2010 Apr; 277(7):1639-52. PubMed ID: 20180845
[TBL] [Abstract][Full Text] [Related]
8. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression.
Boehmer ED; Goral J; Faunce DE; Kovacs EJ
J Leukoc Biol; 2004 Feb; 75(2):342-9. PubMed ID: 14634059
[TBL] [Abstract][Full Text] [Related]
9. Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1 beta gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells.
Chen TL; Chang CC; Lin YL; Ueng YF; Chen RM
Toxicol Appl Pharmacol; 2009 Oct; 240(1):15-25. PubMed ID: 19540866
[TBL] [Abstract][Full Text] [Related]
10. Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice.
Jung YO; Cho ML; Lee SY; Oh HJ; Park JS; Park MK; Park MJ; Ju JH; Kim SI; Park SH; Kim HY; Min JK
Immunol Lett; 2009 Apr; 123(2):138-43. PubMed ID: 19428561
[TBL] [Abstract][Full Text] [Related]
11. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain.
Kawamoto T; Ii M; Kitazaki T; Iizawa Y; Kimura H
Eur J Pharmacol; 2008 Apr; 584(1):40-8. PubMed ID: 18299127
[TBL] [Abstract][Full Text] [Related]
12. Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages.
Kim JH; Jeong JH; Jeon ST; Kim H; Ock J; Suk K; Kim SI; Song KS; Lee WH
Mol Pharmacol; 2006 Jun; 69(6):1783-90. PubMed ID: 16510559
[TBL] [Abstract][Full Text] [Related]
13. Lipid rafts regulate ethanol-induced activation of TLR4 signaling in murine macrophages.
Fernandez-Lizarbe S; Pascual M; Gascon MS; Blanco A; Guerri C
Mol Immunol; 2008 Apr; 45(7):2007-16. PubMed ID: 18061674
[TBL] [Abstract][Full Text] [Related]
14. Regulation of murine macrophage proinflammatory and anti-inflammatory cytokines by ligands for peroxisome proliferator-activated receptor-gamma: counter-regulatory activity by IFN-gamma.
Alleva DG; Johnson EB; Lio FM; Boehme SA; Conlon PJ; Crowe PD
J Leukoc Biol; 2002 Apr; 71(4):677-85. PubMed ID: 11927655
[TBL] [Abstract][Full Text] [Related]
15. CC chemokine ligand 17 in periodontal diseases: expression in diseased tissues and production by human gingival fibroblasts.
Hosokawa Y; Hosokawa I; Ozaki K; Nakae H; Matsuo T
J Periodontal Res; 2008 Aug; 43(4):471-7. PubMed ID: 18557811
[TBL] [Abstract][Full Text] [Related]
16. Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells.
Aki D; Minoda Y; Yoshida H; Watanabe S; Yoshida R; Takaesu G; Chinen T; Inaba T; Hikida M; Kurosaki T; Saeki K; Yoshimura A
Genes Cells; 2008 Feb; 13(2):199-208. PubMed ID: 18233961
[TBL] [Abstract][Full Text] [Related]
17. Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-kappaB signaling pathway in murine macrophages.
Jung HW; Seo UK; Kim JH; Leem KH; Park YK
J Ethnopharmacol; 2009 Mar; 122(2):313-9. PubMed ID: 19162159
[TBL] [Abstract][Full Text] [Related]
18. Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae.
van der Graaf CA; Netea MG; Verschueren I; van der Meer JW; Kullberg BJ
Infect Immun; 2005 Nov; 73(11):7458-64. PubMed ID: 16239547
[TBL] [Abstract][Full Text] [Related]
19. Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.
Mäkelä SM; Strengell M; Pietilä TE; Osterlund P; Julkunen I
J Leukoc Biol; 2009 Apr; 85(4):664-72. PubMed ID: 19164128
[TBL] [Abstract][Full Text] [Related]
20. Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells.
Uno K; Kato K; Atsumi T; Suzuki T; Yoshitake J; Morita H; Ohara S; Kotake Y; Shimosegawa T; Yoshimura T
Am J Physiol Gastrointest Liver Physiol; 2007 Nov; 293(5):G1004-12. PubMed ID: 17855767
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]