180 related articles for article (PubMed ID: 16379042)
1. In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug.
Brandon EF; Sparidans RW; Guijt KJ; Löwenthal S; Meijerman I; Beijnen JH; Schellens JH
Invest New Drugs; 2006 Jan; 24(1):3-14. PubMed ID: 16379042
[TBL] [Abstract][Full Text] [Related]
2. In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction.
Brandon EF; Meijerman I; Klijn JS; den Arend D; Sparidans RW; Lázaro LL; Beijnen JH; Schellens JH
Anticancer Drugs; 2005 Oct; 16(9):935-43. PubMed ID: 16162970
[TBL] [Abstract][Full Text] [Related]
3. In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug.
Brandon EF; Sparidans RW; Meijerman I; Manzanares I; Beijnen JH; Schellens JH
Invest New Drugs; 2004 Aug; 22(3):241-51. PubMed ID: 15122071
[TBL] [Abstract][Full Text] [Related]
4. In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug.
Brandon EF; Sparidans RW; van Ooijen RD; Meijerman I; Lazaro LL; Manzanares I; Beijnen JH; Schellens JH
Invest New Drugs; 2007 Feb; 25(1):9-19. PubMed ID: 16633717
[TBL] [Abstract][Full Text] [Related]
5. In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.
Vermeir M; Hemeryck A; Cuyckens F; Francesch A; Bockx M; Van Houdt J; Steemans K; Mannens G; Avilés P; De Coster R
Biochem Pharmacol; 2009 May; 77(10):1642-54. PubMed ID: 19426702
[TBL] [Abstract][Full Text] [Related]
6. Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.
Sparidans RW; Rosing H; Hillebrand MJ; López-Lázaro L; Jimeno JM; Manzanares I; van Kesteren C; Cvitkovic E; van Oosterom AT; Schellens JH; Beijnen JH
Anticancer Drugs; 2001 Sep; 12(8):653-66. PubMed ID: 11604552
[TBL] [Abstract][Full Text] [Related]
7. Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans.
Reid JM; Kuffel MJ; Ruben SL; Morales JJ; Rinehart KL; Squillace DP; Ames MM
Clin Cancer Res; 2002 Sep; 8(9):2952-62. PubMed ID: 12231541
[TBL] [Abstract][Full Text] [Related]
8. Metabolite Profiling and Reaction Phenotyping for the
Yadav AS; Shah NR; Carlson TJ; Driscoll JP
Chem Res Toxicol; 2020 Jan; 33(1):249-257. PubMed ID: 31815452
[TBL] [Abstract][Full Text] [Related]
9. Identification of the human liver cytochrome P450 isoenzymes responsible for the 5-methylhydroxylation of the novel anti-fibrotic drug AKF-PD.
He X; Luo X; Liu Z; Hu G; Cheng Z
Xenobiotica; 2011 Oct; 41(10):844-50. PubMed ID: 21679010
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans.
Mössner LD; Schmitz A; Theurillat R; Thormann W; Mevissen M
Am J Vet Res; 2011 Nov; 72(11):1505-13. PubMed ID: 22023129
[TBL] [Abstract][Full Text] [Related]
11. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.
Zhang D; Wang L; Chandrasena G; Ma L; Zhu M; Zhang H; Davis CD; Humphreys WG
Drug Metab Dispos; 2007 Jan; 35(1):139-49. PubMed ID: 17062778
[TBL] [Abstract][Full Text] [Related]
12. Sequential metabolism of sesamin by cytochrome P450 and UDP-glucuronosyltransferase in human liver.
Yasuda K; Ikushiro S; Kamakura M; Munetsuna E; Ohta M; Sakaki T
Drug Metab Dispos; 2011 Sep; 39(9):1538-45. PubMed ID: 21622626
[TBL] [Abstract][Full Text] [Related]
13. Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines.
Zhuang XM; Chen L; Tan Y; Yang HY; Lu C; Gao Y; Li H
Chin J Nat Med; 2017 Sep; 15(9):695-702. PubMed ID: 28991531
[TBL] [Abstract][Full Text] [Related]
14. Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.
Gerber JG; Rhodes RJ; Gal J
Chirality; 2004 Jan; 16(1):36-44. PubMed ID: 14628297
[TBL] [Abstract][Full Text] [Related]
15. In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes.
Bendikov MY; Miners JO; Simpson BS; Elliot DJ; Semple SJ; Claudie DJ; McKinnon RA; Gillam EMJ; Sykes MJ
Xenobiotica; 2017 Jun; 47(6):461-469. PubMed ID: 27412850
[TBL] [Abstract][Full Text] [Related]
16. Anthraquinone biocolourant dermocybin is metabolized whereas dermorubin is not in in vitro liver fractions and recombinant metabolic enzymes.
Yli-Öyrä J; Juvonen RO; Lehtonen M; Herrala M; Finel M; Räisänen R; Rysä J
Basic Clin Pharmacol Toxicol; 2024 Jun; 134(6):846-857. PubMed ID: 38664998
[TBL] [Abstract][Full Text] [Related]
17. Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer.
Beyerle J; Frei E; Stiborova M; Habermann N; Ulrich CM
Drug Metab Rev; 2015 May; 47(2):199-221. PubMed ID: 25686853
[TBL] [Abstract][Full Text] [Related]
18. Allometric scaling of hepatic biotransformation in rainbow trout.
Fitzsimmons PN; Hoffman AD; Fay KA; Nichols JW
Comp Biochem Physiol C Toxicol Pharmacol; 2018 Dec; 214():52-60. PubMed ID: 30172734
[TBL] [Abstract][Full Text] [Related]
19. In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.
Hong H; Su H; Ma L; Yao M; Iyer RA; Humphreys WG; Christopher LJ
Drug Metab Dispos; 2011 Sep; 39(9):1658-67. PubMed ID: 21673131
[TBL] [Abstract][Full Text] [Related]
20. Metabolism of clozapine by cDNA-expressed human cytochrome P450 enzymes.
Linnet K; Olesen OV
Drug Metab Dispos; 1997 Dec; 25(12):1379-82. PubMed ID: 9394027
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
