These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Active site of epoxide hydrolases revisited: a noncanonical residue in potato StEH1 promotes both formation and breakdown of the alkylenzyme intermediate. Thomaeus A; Carlsson J; Aqvist J; Widersten M Biochemistry; 2007 Mar; 46(9):2466-79. PubMed ID: 17284015 [TBL] [Abstract][Full Text] [Related]
4. Epoxide hydrolase-catalyzed enantioselective conversion of trans-stilbene oxide: Insights into the reaction mechanism from steady-state and pre-steady-state enzyme kinetics. Archelas A; Zhao W; Faure B; Iacazio G; Kotik M Arch Biochem Biophys; 2016 Feb; 591():66-75. PubMed ID: 26714303 [TBL] [Abstract][Full Text] [Related]
5. Tyrosine residues serve as proton donor in the catalytic mechanism of epoxide hydrolase from Agrobacterium radiobacter. Rink R; Kingma J; Lutje Spelberg JH; Janssen DB Biochemistry; 2000 May; 39(18):5600-13. PubMed ID: 10820034 [TBL] [Abstract][Full Text] [Related]
6. Substrate-dependent hysteretic behavior in StEH1-catalyzed hydrolysis of styrene oxide derivatives. Lindberg D; Gogoll A; Widersten M FEBS J; 2008 Dec; 275(24):6309-20. PubMed ID: 19016837 [TBL] [Abstract][Full Text] [Related]
7. Temperature and pH dependence of enzyme-catalyzed hydrolysis of trans-methylstyrene oxide. A unifying kinetic model for observed hysteresis, cooperativity, and regioselectivity. Lindberg D; de la Fuente Revenga M; Widersten M Biochemistry; 2010 Mar; 49(10):2297-304. PubMed ID: 20146441 [TBL] [Abstract][Full Text] [Related]
9. Deep eutectic solvents (DESs) are viable cosolvents for enzyme-catalyzed epoxide hydrolysis. Lindberg D; de la Fuente Revenga M; Widersten M J Biotechnol; 2010 Jun; 147(3-4):169-71. PubMed ID: 20438773 [TBL] [Abstract][Full Text] [Related]
10. Expression of rat microsomal epoxide hydrolase in Escherichia coli. Identification of a histidyl residue essential for catalysis. Bell PA; Kasper CB J Biol Chem; 1993 Jul; 268(19):14011-7. PubMed ID: 8314768 [TBL] [Abstract][Full Text] [Related]
11. Modification of substrate specificity resulting in an epoxide hydrolase with shifted enantiopreference for (2,3-epoxypropyl)benzene. Gurell A; Widersten M Chembiochem; 2010 Jul; 11(10):1422-9. PubMed ID: 20544772 [TBL] [Abstract][Full Text] [Related]
12. Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: analysis and mechanistic implications. Poelarends GJ; Serrano H; Johnson WH; Whitman CP Biochemistry; 2004 Jun; 43(22):7187-96. PubMed ID: 15170356 [TBL] [Abstract][Full Text] [Related]
13. Mutations in salt-bridging residues at the interface of the core and lid domains of epoxide hydrolase StEH1 affect regioselectivity, protein stability and hysteresis. Lindberg D; Ahmad S; Widersten M Arch Biochem Biophys; 2010 Mar; 495(2):165-73. PubMed ID: 20079707 [TBL] [Abstract][Full Text] [Related]
14. Kinetic mechanism of the enantioselective conversion of styrene oxide by epoxide hydrolase from Agrobacterium radiobacter AD1. Rink R; Janssen DB Biochemistry; 1998 Dec; 37(51):18119-27. PubMed ID: 9922181 [TBL] [Abstract][Full Text] [Related]
15. Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides. Bellucci G; Chiappe C; Ingrosso G Chirality; 1994; 6(7):577-82. PubMed ID: 7986671 [TBL] [Abstract][Full Text] [Related]
16. Catalytic mechanism of scytalone dehydratase: site-directed mutagenisis, kinetic isotope effects, and alternate substrates. Basarab GS; Steffens JJ; Wawrzak Z; Schwartz RS; Lundqvist T; Jordan DB Biochemistry; 1999 May; 38(19):6012-24. PubMed ID: 10320327 [TBL] [Abstract][Full Text] [Related]
17. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. Argiriadi MA; Morisseau C; Goodrow MH; Dowdy DL; Hammock BD; Christianson DW J Biol Chem; 2000 May; 275(20):15265-70. PubMed ID: 10747889 [TBL] [Abstract][Full Text] [Related]
18. Laboratory-Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis. Janfalk Carlsson Å; Bauer P; Dobritzsch D; Nilsson M; Kamerlin SC; Widersten M Chembiochem; 2016 Sep; 17(18):1693-7. PubMed ID: 27383542 [TBL] [Abstract][Full Text] [Related]
19. Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. Yamada T; Morisseau C; Maxwell JE; Argiriadi MA; Christianson DW; Hammock BD J Biol Chem; 2000 Jul; 275(30):23082-8. PubMed ID: 10806198 [TBL] [Abstract][Full Text] [Related]
20. Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine. Schlegel BP; Ratnam K; Penning TM Biochemistry; 1998 Aug; 37(31):11003-11. PubMed ID: 9692994 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]