BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

283 related articles for article (PubMed ID: 16391801)

  • 1. Delivery of the bacterial nitroreductase gene into endothelial cells prolongs the survival of tumour-bearing mice by bystander mechanisms.
    Benouchan M; Do Nascimento F; Perret GY; Colombo BM
    Int J Oncol; 2006 Feb; 28(2):457-62. PubMed ID: 16391801
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bystander cell killing spreading from endothelial to tumor cells in a three-dimensional multicellular nodule model after Escherichia coli nitroreductase gene delivery.
    Benouchan M; Do Nascimento F; Sebbah-Louriki M; Salzmann JL; Crépin M; Perret GY; Colombo BM
    Biochem Biophys Res Commun; 2003 Nov; 311(4):822-8. PubMed ID: 14623255
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: induction of bystander killing in vitro and in vivo.
    Westphal EM; Ge J; Catchpole JR; Ford M; Kenney SC
    Cancer Gene Ther; 2000 Jan; 7(1):97-106. PubMed ID: 10678362
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
    Hay MP; Anderson RF; Ferry DM; Wilson WR; Denny WA
    J Med Chem; 2003 Dec; 46(25):5533-45. PubMed ID: 14640560
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
    Hay MP; Atwell GJ; Wilson WR; Pullen SM; Denny WA
    J Med Chem; 2003 Jun; 46(12):2456-66. PubMed ID: 12773049
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors.
    Djeha AH; Thomson TA; Leung H; Searle PF; Young LS; Kerr DJ; Harris PA; Mountain A; Wrighton CJ
    Mol Ther; 2001 Feb; 3(2):233-40. PubMed ID: 11237680
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.
    McNeish IA; Green NK; Gilligan MG; Ford MJ; Mautner V; Young LS; Kerr DJ; Searle PF
    Gene Ther; 1998 Aug; 5(8):1061-9. PubMed ID: 10326029
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.
    Drabek D; Guy J; Craig R; Grosveld F
    Gene Ther; 1997 Feb; 4(2):93-100. PubMed ID: 9081711
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.
    Helsby NA; Atwell GJ; Yang S; Palmer BD; Anderson RF; Pullen SM; Ferry DM; Hogg A; Wilson WR; Denny WA
    J Med Chem; 2004 Jun; 47(12):3295-307. PubMed ID: 15163209
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
    Atwell GJ; Yang S; Pruijn FB; Pullen SM; Hogg A; Patterson AV; Wilson WR; Denny WA
    J Med Chem; 2007 Mar; 50(6):1197-212. PubMed ID: 17326614
    [TBL] [Abstract][Full Text] [Related]  

  • 11. E. coli nitroreductase/CB1954 gene-directed enzyme prodrug therapy: role of arylamine N-acetlytransferase 2.
    Mitchell DJ; Minchin RF
    Cancer Gene Ther; 2008 Nov; 15(11):758-64. PubMed ID: 18600257
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.
    Plumb JA; Bilsland A; Kakani R; Zhao J; Glasspool RM; Knox RJ; Evans TR; Keith WN
    Oncogene; 2001 Nov; 20(53):7797-803. PubMed ID: 11753658
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Escherichia coli nitroreductase plus CB1954 enhances the effect of radiotherapy in vitro and in vivo.
    White CL; Menghistu T; Twigger KR; Searle PF; Bhide SA; Vile RG; Melcher AA; Pandha HS; Harrington KJ
    Gene Ther; 2008 Mar; 15(6):424-33. PubMed ID: 18079753
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954.
    Djeha AH; Hulme A; Dexter MT; Mountain A; Young LS; Searle PF; Kerr DJ; Wrighton CJ
    Cancer Gene Ther; 2000 May; 7(5):721-31. PubMed ID: 10830719
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector.
    Chen MJ; Green NK; Reynolds GM; Flavell JR; Mautner V; Kerr DJ; Young LS; Searle PF
    Gene Ther; 2004 Jul; 11(14):1126-36. PubMed ID: 15164095
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Virus-directed enzyme prodrug therapy using CB1954.
    Grove JI; Searle PF; Weedon SJ; Green NK; McNeish IA; Kerr DJ
    Anticancer Drug Des; 1999 Dec; 14(6):461-72. PubMed ID: 10834268
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.
    Prosser GA; Copp JN; Syddall SP; Williams EM; Smaill JB; Wilson WR; Patterson AV; Ackerley DF
    Biochem Pharmacol; 2010 Mar; 79(5):678-87. PubMed ID: 19852945
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.
    Searle PF; Chen MJ; Hu L; Race PR; Lovering AL; Grove JI; Guise C; Jaberipour M; James ND; Mautner V; Young LS; Kerr DJ; Mountain A; White SA; Hyde EI
    Clin Exp Pharmacol Physiol; 2004 Nov; 31(11):811-6. PubMed ID: 15566399
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro.
    Hunt MA; Li D; Hay MP; Currie MJ; Robinson BA; Patterson AV; Dachs GU
    J Gene Med; 2012 Jan; 14(1):62-74. PubMed ID: 22147660
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals.
    Bhaumik S; Sekar TV; Depuy J; Klimash J; Paulmurugan R
    Gene Ther; 2012 Mar; 19(3):295-302. PubMed ID: 21753794
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.