160 related articles for article (PubMed ID: 16404529)
1. Similarity study of serine proteases inhibitors.
Perekhodtsev GD
Mol Divers; 2006 Feb; 10(1):81-3. PubMed ID: 16404529
[TBL] [Abstract][Full Text] [Related]
2. Three-dimensional quantitative structure-activity relationship analyses using comparative molecular field analysis and comparative molecular similarity indices analysis to elucidate selectivity differences of inhibitors binding to trypsin, thrombin, and factor Xa.
Böhm M; St rzebecher J; Klebe G
J Med Chem; 1999 Feb; 42(3):458-77. PubMed ID: 9986717
[TBL] [Abstract][Full Text] [Related]
3. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
Bhunia SS; Roy KK; Saxena AK
J Chem Inf Model; 2011 Aug; 51(8):1966-85. PubMed ID: 21761917
[TBL] [Abstract][Full Text] [Related]
4. Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
Stubbs MT; Huber R; Bode W
FEBS Lett; 1995 Nov; 375(1-2):103-7. PubMed ID: 7498454
[TBL] [Abstract][Full Text] [Related]
5. Evaluation of bisbenzamidines as inhibitors for matriptase-2.
Beckmann AM; Gilberg E; Gattner S; Huang TL; Vanden Eynde JJ; Mayence A; Bajorath J; Stirnberg M; Gütschow M
Bioorg Med Chem Lett; 2016 Aug; 26(15):3741-5. PubMed ID: 27287367
[TBL] [Abstract][Full Text] [Related]
6. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
[TBL] [Abstract][Full Text] [Related]
7. Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity.
Shaw KJ; Guilford WJ; Griedel BD; Sakata S; Trinh L; Wu S; Xu W; Zhao Z; Morrissey MM
Bioorg Med Chem Lett; 2002 May; 12(9):1311-4. PubMed ID: 11965378
[TBL] [Abstract][Full Text] [Related]
8. 1,2-Dibenzamidobenzene inhibitors of human factor Xa.
Herron DK; Goodson T; Wiley MR; Weir LC; Kyle JA; Yee YK; Tebbe AL; Tinsley JM; Mendel D; Masters JJ; Franciskovich JB; Sawyer JS; Beight DW; Ratz AM; Milot G; Hall SE; Klimkowski VJ; Wikel JH; Eastwood BJ; Towner RD; Gifford-Moore DS; Craft TJ; Smith GF
J Med Chem; 2000 Mar; 43(5):859-72. PubMed ID: 10715153
[TBL] [Abstract][Full Text] [Related]
9. Understanding binding selectivity toward trypsin and factor Xa: the role of aromatic interactions.
Di Fenza A; Heine A; Koert U; Klebe G
ChemMedChem; 2007 Mar; 2(3):297-308. PubMed ID: 17191291
[TBL] [Abstract][Full Text] [Related]
10. Inhibitors of serine proteinases from blood coagulation cascade - view on current developments.
Danalev D
Mini Rev Med Chem; 2012 Jul; 12(8):721-30. PubMed ID: 22512557
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.
Phillips G; Guilford WJ; Buckman BO; Davey DD; Eagen KA; Koovakkat S; Liang A; McCarrick M; Mohan R; Ng HP; Pinkerton M; Subramanyam B; Ho E; Trinh L; Whitlow M; Wu S; Xu W; Morrissey MM
J Med Chem; 2002 Jun; 45(12):2484-93. PubMed ID: 12036356
[TBL] [Abstract][Full Text] [Related]
12. Comparative binding energy analysis considering multiple receptors: a step toward 3D-QSAR models for multiple targets.
Murcia M; Morreale A; Ortiz AR
J Med Chem; 2006 Oct; 49(21):6241-53. PubMed ID: 17034130
[TBL] [Abstract][Full Text] [Related]
13. Recent advances in serine protease inhibitors as anticoagulant agents.
Prezelj A; Anderluh PS; Peternel L; Urleb U
Curr Pharm Des; 2007; 13(3):287-312. PubMed ID: 17313362
[TBL] [Abstract][Full Text] [Related]
14. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
Krishnan R; Zhang E; Hakansson K; Arni RK; Tulinsky A; Lim-Wilby MS; Levy OE; Semple JE; Brunck TK
Biochemistry; 1998 Sep; 37(35):12094-103. PubMed ID: 9724521
[TBL] [Abstract][Full Text] [Related]
15. A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.
Olsen JA; Banner DW; Seiler P; Obst Sander U; D'Arcy A; Stihle M; Müller K; Diederich F
Angew Chem Int Ed Engl; 2003 Jun; 42(22):2507-11. PubMed ID: 12800172
[No Abstract] [Full Text] [Related]
16. (Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.
Shaw KJ; Guilford WJ; Dallas JL; Koovakkaat SK; McCarrick MA; Liang A; Light DR; Morrissey MM
J Med Chem; 1998 Sep; 41(19):3551-6. PubMed ID: 9733479
[No Abstract] [Full Text] [Related]
17. Contribution of explicit solvent effects to the binding affinity of small-molecule inhibitors in blood coagulation factor serine proteases.
Abel R; Salam NK; Shelley J; Farid R; Friesner RA; Sherman W
ChemMedChem; 2011 Jun; 6(6):1049-66. PubMed ID: 21506273
[TBL] [Abstract][Full Text] [Related]
18. Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors.
Pilgram O; Keils A; Benary GE; Müller J; Merkl S; Ngaha S; Huber S; Chevillard F; Harbig A; Magdolen V; Heine A; Böttcher-Friebertshäuser E; Steinmetzer T
Eur J Med Chem; 2022 Aug; 238():114437. PubMed ID: 35635944
[TBL] [Abstract][Full Text] [Related]
19. Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.
Wagner J; Kallen J; Ehrhardt C; Evenou JP; Wagner D
J Med Chem; 1998 Sep; 41(19):3664-74. PubMed ID: 9733491
[TBL] [Abstract][Full Text] [Related]
20. Dual inhibitors of the blood coagulation enzymes.
Kranjc A; Kikelj D
Curr Med Chem; 2004 Oct; 11(19):2535-47. PubMed ID: 15544461
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]