1279 related articles for article (PubMed ID: 16405513)
1. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
3. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
4. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
5. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
6. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
7. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
8. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
De Strooper B; Saftig P; Craessaerts K; Vanderstichele H; Guhde G; Annaert W; Von Figura K; Van Leuven F
Nature; 1998 Jan; 391(6665):387-90. PubMed ID: 9450754
[TBL] [Abstract][Full Text] [Related]
9. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
[TBL] [Abstract][Full Text] [Related]
10. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
11. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
[TBL] [Abstract][Full Text] [Related]
12. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
13. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
Walker ES; Martinez M; Brunkan AL; Goate A
J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
[TBL] [Abstract][Full Text] [Related]
14. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.
Brunkan AL; Martinez M; Wang J; Walker ES; Beher D; Shearman MS; Goate AM
J Neurochem; 2005 Sep; 94(5):1315-28. PubMed ID: 16001967
[TBL] [Abstract][Full Text] [Related]
15. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
[TBL] [Abstract][Full Text] [Related]
16. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
17. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
[TBL] [Abstract][Full Text] [Related]
18. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
[TBL] [Abstract][Full Text] [Related]
19. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
J Neurochem; 2004 Apr; 89(1):44-53. PubMed ID: 15030388
[TBL] [Abstract][Full Text] [Related]
20. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; Serneels L; Saftig P; Craessaerts K; De Strooper B; Hartmann D
Hum Mol Genet; 2004 Jul; 13(13):1321-31. PubMed ID: 15128703
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
