319 related articles for article (PubMed ID: 16407538)
21. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
Farzan M; Schnitzler CE; Vasilieva N; Leung D; Choe H
Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9712-7. PubMed ID: 10931940
[TBL] [Abstract][Full Text] [Related]
22. The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate.
Yan R; Han P; Miao H; Greengard P; Xu H
J Biol Chem; 2001 Sep; 276(39):36788-96. PubMed ID: 11466313
[TBL] [Abstract][Full Text] [Related]
23. Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase.
Huse JT; Pijak DS; Leslie GJ; Lee VM; Doms RW
J Biol Chem; 2000 Oct; 275(43):33729-37. PubMed ID: 10924510
[TBL] [Abstract][Full Text] [Related]
24. A non-amyloidogenic function of BACE-2 in the secretory pathway.
Fluhrer R; Capell A; Westmeyer G; Willem M; Hartung B; Condron MM; Teplow DB; Haass C; Walter J
J Neurochem; 2002 Jun; 81(5):1011-20. PubMed ID: 12065613
[TBL] [Abstract][Full Text] [Related]
25. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.
Lammich S; Kojro E; Postina R; Gilbert S; Pfeiffer R; Jasionowski M; Haass C; Fahrenholz F
Proc Natl Acad Sci U S A; 1999 Mar; 96(7):3922-7. PubMed ID: 10097139
[TBL] [Abstract][Full Text] [Related]
26. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.
Hook VY; Toneff T; Aaron W; Yasothornsrikul S; Bundey R; Reisine T
J Neurochem; 2002 Apr; 81(2):237-56. PubMed ID: 12064471
[TBL] [Abstract][Full Text] [Related]
27. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
McPhie DL; Golde T; Eckman CB; Yager D; Brant JB; Neve RL
Brain Res Mol Brain Res; 2001 Dec; 97(1):103-13. PubMed ID: 11744168
[TBL] [Abstract][Full Text] [Related]
28. Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
Benjannet S; Elagoz A; Wickham L; Mamarbachi M; Munzer JS; Basak A; Lazure C; Cromlish JA; Sisodia S; Checler F; Chrétien M; Seidah NG
J Biol Chem; 2001 Apr; 276(14):10879-87. PubMed ID: 11152688
[TBL] [Abstract][Full Text] [Related]
29. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.
Bennett BD; Denis P; Haniu M; Teplow DB; Kahn S; Louis JC; Citron M; Vassar R
J Biol Chem; 2000 Dec; 275(48):37712-7. PubMed ID: 10956649
[TBL] [Abstract][Full Text] [Related]
30. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
Walsh DM; Fadeeva JV; LaVoie MJ; Paliga K; Eggert S; Kimberly WT; Wasco W; Selkoe DJ
Biochemistry; 2003 Jun; 42(22):6664-73. PubMed ID: 12779321
[TBL] [Abstract][Full Text] [Related]
31. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
Fluhrer R; Multhaup G; Schlicksupp A; Okochi M; Takeda M; Lammich S; Willem M; Westmeyer G; Bode W; Walter J; Haass C
J Biol Chem; 2003 Feb; 278(8):5531-8. PubMed ID: 12471021
[TBL] [Abstract][Full Text] [Related]
32. Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.
Eggert S; Gonzalez AC; Thomas C; Schilling S; Schwarz SM; Tischer C; Adam V; Strecker P; Schmidt V; Willnow TE; Hermey G; Pietrzik CU; Koo EH; Kins S
Cell Mol Life Sci; 2018 Jan; 75(2):301-322. PubMed ID: 28799085
[TBL] [Abstract][Full Text] [Related]
33. The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase.
Nunan J; Shearman MS; Checler F; Cappai R; Evin G; Beyreuther K; Masters CL; Small DH
Eur J Biochem; 2001 Oct; 268(20):5329-36. PubMed ID: 11606195
[TBL] [Abstract][Full Text] [Related]
34. Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.
Bodendorf U; Danner S; Fischer F; Stefani M; Sturchler-Pierrat C; Wiederhold KH; Staufenbiel M; Paganetti P
J Neurochem; 2002 Mar; 80(5):799-806. PubMed ID: 11948243
[TBL] [Abstract][Full Text] [Related]
35. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.
Tomita S; Kirino Y; Suzuki T
J Biol Chem; 1998 Mar; 273(11):6277-84. PubMed ID: 9497354
[TBL] [Abstract][Full Text] [Related]
36. Metabolites of the beta-amyloid precursor protein generated by beta-secretase localise to the trans-Golgi network and late endosome in 293 cells.
Stephens DJ; Austen BM
J Neurosci Res; 1996 Oct; 46(2):211-25. PubMed ID: 8915898
[TBL] [Abstract][Full Text] [Related]
37. X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
Saito Y; Sano Y; Vassar R; Gandy S; Nakaya T; Yamamoto T; Suzuki T
J Biol Chem; 2008 Dec; 283(51):35763-71. PubMed ID: 18845544
[TBL] [Abstract][Full Text] [Related]
38. Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells.
Sahasrabudhe SR; Spruyt MA; Muenkel HA; Blume AJ; Vitek MP; Jacobsen JS
J Biol Chem; 1992 Dec; 267(35):25602-8. PubMed ID: 1281162
[TBL] [Abstract][Full Text] [Related]
39. Maturation and pro-peptide cleavage of beta-secretase.
Capell A; Steiner H; Willem M; Kaiser H; Meyer C; Walter J; Lammich S; Multhaup G; Haass C
J Biol Chem; 2000 Oct; 275(40):30849-54. PubMed ID: 10801872
[TBL] [Abstract][Full Text] [Related]
40. Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing.
Knupp A; Mishra S; Martinez R; Braggin JE; Szabo M; Kinoshita C; Hailey DW; Small SA; Jayadev S; Young JE
Cell Rep; 2020 Jun; 31(9):107719. PubMed ID: 32492427
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]