164 related articles for article (PubMed ID: 16420047)
1. Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor.
Lang M; De Pol S; Baldauf C; Hofmann HJ; Reiser O; Beck-Sickinger AG
J Med Chem; 2006 Jan; 49(2):616-24. PubMed ID: 16420047
[TBL] [Abstract][Full Text] [Related]
2. Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produce antagonists with increased affinity.
Smith DD; Saha S; Fang G; Schaffert C; Waugh DJ; Zeng W; Toth G; Hulce M; Abel PW
J Med Chem; 2003 Jun; 46(12):2427-35. PubMed ID: 12773046
[TBL] [Abstract][Full Text] [Related]
3. Structure-activity studies on position 14 of human alpha-calcitonin gene-related peptide.
Li J; Matsuura JE; Waugh DJ; Adrian TE; Abel PW; Manning MC; Smith DD
J Med Chem; 1997 Sep; 40(19):3071-6. PubMed ID: 9301670
[TBL] [Abstract][Full Text] [Related]
4. Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.
Burgey CS; Potteiger CM; Deng JZ; Mosser SD; Salvatore CA; Yu S; Roller S; Kane SA; Vacca JP; Williams TM
Bioorg Med Chem Lett; 2009 Nov; 19(22):6368-72. PubMed ID: 19818613
[TBL] [Abstract][Full Text] [Related]
5. Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor.
Boeglin D; Hamdan FF; Melendez RE; Cluzeau J; Laperriere A; Héroux M; Bouvier M; Lubell WD
J Med Chem; 2007 Mar; 50(6):1401-8. PubMed ID: 17319653
[TBL] [Abstract][Full Text] [Related]
6. From micromolar to nanomolar affinity: a systematic approach to identify the binding site of CGRP at the human calcitonin gene-related peptide 1 receptor.
Rist B; Entzeroth M; Beck-Sickinger AG
J Med Chem; 1998 Jan; 41(1):117-23. PubMed ID: 9438028
[TBL] [Abstract][Full Text] [Related]
7. Constrained analogues of the calcitonin gene-related peptide.
Hakala JM; Valo T; Vihavainen S; Hermonen J; Heino P; Halme M; Koskinen AM
Biochem Biophys Res Commun; 1994 Jul; 202(1):497-503. PubMed ID: 8037754
[TBL] [Abstract][Full Text] [Related]
8. Pharmacologic study of C-terminal fragments of frog skin calcitonin gene-related peptide.
Ladram A; Besné I; Breton L; de Lacharrière O; Nicolas P; Amiche M
Peptides; 2008 Jul; 29(7):1150-6. PubMed ID: 18395938
[TBL] [Abstract][Full Text] [Related]
9. Pharmacological characterization of novel alpha-Calcitonin Gene-Related Peptide (CGRP) receptor peptide antagonists that are selective for human CGRP receptors.
Taylor CK; Smith DD; Hulce M; Abel PW
J Pharmacol Exp Ther; 2006 Nov; 319(2):749-57. PubMed ID: 16873605
[TBL] [Abstract][Full Text] [Related]
10. Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.
Miranda LP; Holder JR; Shi L; Bennett B; Aral J; Gegg CV; Wright M; Walker K; Doellgast G; Rogers R; Li H; Valladares V; Salyers K; Johnson E; Wild K
J Med Chem; 2008 Dec; 51(24):7889-97. PubMed ID: 19053766
[TBL] [Abstract][Full Text] [Related]
11. Turn structures in CGRP C-terminal analogues promote stable arrangements of key residue side chains.
Carpenter KA; Schmidt R; von Mentzer B; Haglund U; Roberts E; Walpole C
Biochemistry; 2001 Jul; 40(28):8317-25. PubMed ID: 11444978
[TBL] [Abstract][Full Text] [Related]
12. Comparative affinities and antagonistic potencies of various human calcitonin gene-related peptide fragments on calcitonin gene-related peptide receptors in brain and periphery.
Mimeault M; Fournier A; Dumont Y; St-Pierre S; Quirion R
J Pharmacol Exp Ther; 1991 Sep; 258(3):1084-90. PubMed ID: 1653835
[TBL] [Abstract][Full Text] [Related]
13. Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells.
Pin SS; Xu C; Bahr BA
Eur J Pharmacol; 2007 Dec; 577(1-3):7-16. PubMed ID: 17825280
[TBL] [Abstract][Full Text] [Related]
14. Identification and pharmacological characterization of domains involved in binding of CGRP receptor antagonists to the calcitonin-like receptor.
Salvatore CA; Mallee JJ; Bell IM; Zartman CB; Williams TM; Koblan KS; Kane SA
Biochemistry; 2006 Feb; 45(6):1881-7. PubMed ID: 16460034
[TBL] [Abstract][Full Text] [Related]
15. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function.
Qi T; Christopoulos G; Bailey RJ; Christopoulos A; Sexton PM; Hay DL
Mol Pharmacol; 2008 Oct; 74(4):1059-71. PubMed ID: 18593822
[TBL] [Abstract][Full Text] [Related]
16. Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.
Moore EL; Burgey CS; Paone DV; Shaw AW; Tang YS; Kane SA; Salvatore CA
Eur J Pharmacol; 2009 Jan; 602(2-3):250-4. PubMed ID: 19084002
[TBL] [Abstract][Full Text] [Related]
17. Structure of human calcitonin gene-related peptide (hCGRP) and of its antagonist hCGRP 8-37 as determined by NMR and molecular modeling.
Boulanger Y; Khiat A; Chen Y; Senécal L; Tu Y; St-Pierre S; Fournier A
Pept Res; 1995; 8(4):206-13. PubMed ID: 8527874
[TBL] [Abstract][Full Text] [Related]
18. CGRP(2) receptor in the internal anal sphincter of the rat: implications for CGRP receptor classification.
Wisskirchen FM; Marshall I
Br J Pharmacol; 2000 May; 130(2):464-70. PubMed ID: 10807687
[TBL] [Abstract][Full Text] [Related]
19. Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.
Salvatore CA; Hershey JC; Corcoran HA; Fay JF; Johnston VK; Moore EL; Mosser SD; Burgey CS; Paone DV; Shaw AW; Graham SL; Vacca JP; Williams TM; Koblan KS; Kane SA
J Pharmacol Exp Ther; 2008 Feb; 324(2):416-21. PubMed ID: 18039958
[TBL] [Abstract][Full Text] [Related]
20. Structure-activity relationship of calcitonin gene related peptide.
Morita K; Kato I; Uzawa T; Hori M; Noda T
Horm Metab Res; 1989 Dec; 21(12):666-8. PubMed ID: 2613181
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
