254 related articles for article (PubMed ID: 16420062)
1. Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability.
Feng Y; Coward JK
J Med Chem; 2006 Jan; 49(2):770-88. PubMed ID: 16420062
[TBL] [Abstract][Full Text] [Related]
2. A stereoselective synthesis of phosphinic acid phosphapeptides corresponding to glutamyl-gamma-glutamate and incorporation into potent inhibitors of folylpoly-gamma-glutamyl synthetase.
Bartley DM; Coward JK
J Org Chem; 2005 Aug; 70(17):6757-74. PubMed ID: 16095295
[TBL] [Abstract][Full Text] [Related]
3. Phosphinic acid pseudopeptides analogous to glutamyl-gamma-glutamate: synthesis and coupling to pteroyl azides leads to potent inhibitors of folylpoly-gamma-glutamate synthetase.
Valiaeva N; Bartley D; Konno T; Coward JK
J Org Chem; 2001 Jul; 66(15):5146-54. PubMed ID: 11463268
[TBL] [Abstract][Full Text] [Related]
4. Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate.
Tsukamoto T; Haile WH; McGuire JJ; Coward JK
Arch Biochem Biophys; 1998 Jul; 355(1):109-18. PubMed ID: 9647673
[TBL] [Abstract][Full Text] [Related]
5. Kinetics and mechanisms of activation of alpha-amino acid ester prodrugs of camptothecins.
Song L; Bevins R; Anderson BD
J Med Chem; 2006 Jul; 49(14):4344-55. PubMed ID: 16821794
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and antitumor evaluation of bis[(pivaloyloxy)methyl] 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP): a strategy to introduce nucleotides into cells.
Farquhar D; Khan S; Srivastva DN; Saunders PP
J Med Chem; 1994 Nov; 37(23):3902-9. PubMed ID: 7966151
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins.
DeGraw JI; Christie PH; Brown EG; Kelly LF; Kisliuk RL; Gaumont Y; Sirotnak FM
J Med Chem; 1984 Mar; 27(3):376-80. PubMed ID: 6699882
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and evaluation of water-soluble etoposide esters of malic acid as prodrugs.
Chen J; Du W
Med Chem; 2013 Aug; 9(5):740-7. PubMed ID: 23061567
[TBL] [Abstract][Full Text] [Related]
9. Synthesis of p-aminophenyl aryl H-phosphinic acids and esters via cross-coupling reactions: elaboration to phosphinic acid pseudopeptide analogues of pteroyl glutamic acid and related antifolates.
Yang Y; Coward JK
J Org Chem; 2007 Jul; 72(15):5748-58. PubMed ID: 17602593
[TBL] [Abstract][Full Text] [Related]
10. Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.
Piper JR; DeGraw JI; Colwell WT; Johnson CA; Smith RL; Waud WR; Sirotnak FM
J Med Chem; 1997 Jan; 40(3):377-84. PubMed ID: 9022805
[TBL] [Abstract][Full Text] [Related]
11. Auxiliary in vitro and in vivo biological evaluation of hydrogen peroxide sensitive prodrugs of methotrexate and aminopterin for the treatment of rheumatoid arthritis.
Previtali V; Petrovic K; Peiró Cadahía J; Troelsen NS; Clausen MH
Bioorg Med Chem; 2020 Jan; 28(2):115247. PubMed ID: 31843461
[TBL] [Abstract][Full Text] [Related]
12. Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate.
McGuire JJ; Haile WH; Valiaeva N; Bartley D; Guo J; Coward JK
Biochem Pharmacol; 2003 Feb; 65(3):315-8. PubMed ID: 12527324
[TBL] [Abstract][Full Text] [Related]
13. Analogues of methotrexate and aminopterin with gamma-methylene and gamma-cyano substitution of the glutamate side chain: synthesis and in vitro biological activity.
Rosowsky A; Bader H; Freisheim JH
J Med Chem; 1991 Jan; 34(1):203-8. PubMed ID: 1992118
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological activity of N-2,3-dihydroxypropyl-N-4-chlorobutyl nucleoside phosphoramidate prodrugs.
Wu W; Borch RF
Mol Pharm; 2006; 3(4):451-6. PubMed ID: 16889439
[TBL] [Abstract][Full Text] [Related]
15. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.
Vig BS; Lorenzi PJ; Mittal S; Landowski CP; Shin HC; Mosberg HI; Hilfinger JM; Amidon GL
Pharm Res; 2003 Sep; 20(9):1381-8. PubMed ID: 14567631
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
Rosowsky A; Moran RG; Freisheim JH; Bader H; Forsch RA; Solan VC
NCI Monogr; 1987; (5):145-52. PubMed ID: 3431589
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and in vitro investigations of nalidixic acid amides of amino acid esters as prodrugs.
Aboul-Fadl T; Fouad EA
Pharmazie; 1996 Jan; 51(1):30-3. PubMed ID: 8999431
[TBL] [Abstract][Full Text] [Related]
18. Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
Niculescu-Duvaz D; Niculescu-Duvaz I; Friedlos F; Martin J; Spooner R; Davies L; Marais R; Springer CJ
J Med Chem; 1998 Dec; 41(26):5297-309. PubMed ID: 9857097
[TBL] [Abstract][Full Text] [Related]
19. Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl.
Piper JR; Ramamurthy B; Johnson CA; Otter GM; Sirotnak FM
J Med Chem; 1996 Jan; 39(2):614-8. PubMed ID: 8558535
[TBL] [Abstract][Full Text] [Related]
20. Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs.
Liu WQ; Vidal M; Olszowy C; Million E; Lenoir C; Dhôtel H; Garbay C
J Med Chem; 2004 Feb; 47(5):1223-33. PubMed ID: 14971902
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]