172 related articles for article (PubMed ID: 16420062)
21. Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
Rosowsky A; Moran RG; Freisheim JH; Bader H; Forsch RA; Solan VC
NCI Monogr; 1987; (5):145-52. PubMed ID: 3431589
[TBL] [Abstract][Full Text] [Related]
22. Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
Rosowsky A; Bader H; Kohler W; Freisheim JH; Moran RG
J Med Chem; 1988 Jul; 31(7):1338-44. PubMed ID: 2898531
[TBL] [Abstract][Full Text] [Related]
23. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Thorndike J; Sirotnak FM
J Med Chem; 1988 Nov; 31(11):2164-9. PubMed ID: 3184124
[TBL] [Abstract][Full Text] [Related]
24. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Sirotnak FM
J Med Chem; 1986 Jun; 29(6):1080-7. PubMed ID: 2423690
[TBL] [Abstract][Full Text] [Related]
25. Synthesis, chemical and enzymatic hydrolysis, and bioavailability evaluation in rabbits of metronidazole amino acid ester prodrugs with enhanced water solubility.
Mahfouz NM; Hassan MA
J Pharm Pharmacol; 2001 Jun; 53(6):841-8. PubMed ID: 11428660
[TBL] [Abstract][Full Text] [Related]
26. Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl.
Piper JR; Ramamurthy B; Johnson CA; Otter GM; Sirotnak FM
J Med Chem; 1996 Jan; 39(2):614-8. PubMed ID: 8558535
[TBL] [Abstract][Full Text] [Related]
27. Synthesis and in vitro investigations of nalidixic acid amides of amino acid esters as prodrugs.
Aboul-Fadl T; Fouad EA
Pharmazie; 1996 Jan; 51(1):30-3. PubMed ID: 8999431
[TBL] [Abstract][Full Text] [Related]
28. Novel approaches for designing 5'-O-ester prodrugs of 3'-azido-2', 3'-dideoxythymidine (AZT).
Parang K; Wiebe LI; Knaus EE
Curr Med Chem; 2000 Oct; 7(10):995-1039. PubMed ID: 10911016
[TBL] [Abstract][Full Text] [Related]
29. Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs.
Liu WQ; Vidal M; Olszowy C; Million E; Lenoir C; Dhôtel H; Garbay C
J Med Chem; 2004 Feb; 47(5):1223-33. PubMed ID: 14971902
[TBL] [Abstract][Full Text] [Related]
30. Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).
Piper JR; Johnson CA; Otter GM; Sirotnak FM
J Med Chem; 1992 Aug; 35(16):3002-6. PubMed ID: 1501226
[TBL] [Abstract][Full Text] [Related]
31. Sulfonyl-containing nucleoside phosphotriesters and phosphoramidates as novel anticancer prodrugs of 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP).
Sun YW; Chen KM; Kwon CH
Mol Pharm; 2006; 3(2):161-73. PubMed ID: 16579645
[TBL] [Abstract][Full Text] [Related]
32. Synthesis of new lipophilic ipomeanol analogues and their cytotoxic activities.
Krauss J; Unterreitmeier D
Arch Pharm (Weinheim); 2005 Jan; 338(1):44-8. PubMed ID: 15674804
[TBL] [Abstract][Full Text] [Related]
33. Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
Niculescu-Duvaz D; Niculescu-Duvaz I; Friedlos F; Martin J; Spooner R; Davies L; Marais R; Springer CJ
J Med Chem; 1998 Dec; 41(26):5297-309. PubMed ID: 9857097
[TBL] [Abstract][Full Text] [Related]
34. Sulfonyl-containing aldophosphamide analogues as novel anticancer prodrugs targeted against cyclophosphamide-resistant tumor cell lines.
Jain M; Fan J; Baturay NZ; Kwon CH
J Med Chem; 2004 Jul; 47(15):3843-52. PubMed ID: 15239662
[TBL] [Abstract][Full Text] [Related]
35. Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
Rosowsky A; Bader H; Radike-Smith M; Cucchi CA; Wick MM; Freisheim JH
J Med Chem; 1986 Sep; 29(9):1703-9. PubMed ID: 3462394
[TBL] [Abstract][Full Text] [Related]
36. Synthesis and biological evaluation of 2'-carbamate-linked and 2'-carbonate-linked prodrugs of paclitaxel: selective activation by the tumor-associated protease plasmin.
de Groot FM; van Berkom LW; Scheeren HW
J Med Chem; 2000 Aug; 43(16):3093-102. PubMed ID: 10956217
[TBL] [Abstract][Full Text] [Related]
37. Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
Rosowsky A; Bader H; Cucchi CA; Moran RG; Kohler W; Freisheim JH
J Med Chem; 1988 Jul; 31(7):1332-7. PubMed ID: 3385730
[TBL] [Abstract][Full Text] [Related]
38. Mechanism-based inhibitors of folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase: control of folylpoly-gamma-glutamate homeostasis as a drug target.
Coward JK; McGuire JJ
Vitam Horm; 2008; 79():347-73. PubMed ID: 18804701
[TBL] [Abstract][Full Text] [Related]
39. Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.
Davies LC; Friedlos F; Hedley D; Martin J; Ogilvie LM; Scanlon IJ; Springer CJ
J Med Chem; 2005 Aug; 48(16):5321-8. PubMed ID: 16078849
[TBL] [Abstract][Full Text] [Related]
40. Mechanistic insights into the activation of ester prodrugs of 666-15.
Xie F; Martín-Acosta P; Li BX; Xiao X
Bioorg Med Chem Lett; 2020 Oct; 30(19):127455. PubMed ID: 32730943
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]