These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 16434397)

  • 41. Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation.
    Sun L; Sun X; Xie S; Yu H; Zhong D
    Biochem Biophys Res Commun; 2014 May; 447(3):465-70. PubMed ID: 24732354
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Cytotoxic monastrol derivatives as adjective inhibitors of drug-resistant Eg5: a molecular dynamics perspective.
    Shahabipour S; Shamkhali AN; Razzaghi-Asl N
    J Biomol Struct Dyn; 2024 Mar; ():1-14. PubMed ID: 38450658
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Crystal structure of HsEg5 in complex with clinical candidate CK0238273 provides insight into inhibitory mechanism, potency, and specificity.
    Zhang B; Liu JF; Xu Y; Ng SC
    Biochem Biophys Res Commun; 2008 Aug; 372(4):565-70. PubMed ID: 18503753
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures.
    Yoon SY; Choi JE; Huh JW; Hwang O; Lee HS; Hong HN; Kim D
    Cell Motil Cytoskeleton; 2005 Apr; 60(4):181-90. PubMed ID: 15751098
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Structural basis of new allosteric inhibition in Kinesin spindle protein Eg5.
    Yokoyama H; Sawada J; Katoh S; Matsuno K; Ogo N; Ishikawa Y; Hashimoto H; Fujii S; Asai A
    ACS Chem Biol; 2015 Apr; 10(4):1128-36. PubMed ID: 25622007
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Circular RNA‑MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis.
    Liu Y; Dong Y; Zhao L; Su L; Luo J
    Int J Oncol; 2018 Oct; 53(4):1752-1762. PubMed ID: 30015883
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss.
    Freund RK; Gibson ES; Potter H; Dell'Acqua ML
    Mol Pharmacol; 2016 May; 89(5):552-9. PubMed ID: 26957206
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons.
    Haque SA; Hasaka TP; Brooks AD; Lobanov PV; Baas PW
    Cell Motil Cytoskeleton; 2004 May; 58(1):10-6. PubMed ID: 14983520
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
    Talapatra SK; Tham CL; Guglielmi P; Cirilli R; Chandrasekaran B; Karpoormath R; Carradori S; Kozielski F
    Eur J Med Chem; 2018 Aug; 156():641-651. PubMed ID: 30031975
    [TBL] [Abstract][Full Text] [Related]  

  • 50. X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase.
    Balbo PB; Toth J; Bohm A
    J Mol Biol; 2007 Mar; 366(5):1401-15. PubMed ID: 17223131
    [TBL] [Abstract][Full Text] [Related]  

  • 51. High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations.
    Kikkawa M; Hirokawa N
    EMBO J; 2006 Sep; 25(18):4187-94. PubMed ID: 16946706
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Loop L5 acts as a conformational latch in the mitotic kinesin Eg5.
    Behnke-Parks WM; Vendome J; Honig B; Maliga Z; Moores C; Rosenfeld SS
    J Biol Chem; 2011 Feb; 286(7):5242-53. PubMed ID: 21148480
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Structural insights into a unique inhibitor binding pocket in kinesin spindle protein.
    Ulaganathan V; Talapatra SK; Rath O; Pannifer A; Hackney DD; Kozielski F
    J Am Chem Soc; 2013 Feb; 135(6):2263-72. PubMed ID: 23305346
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol.
    Asraf H; Avunie-Masala R; Hershfinkel M; Gheber L
    PLoS One; 2015; 10(6):e0129255. PubMed ID: 26035434
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α
    Damgaard M; Al-Khawaja A; Nittegaard-Nielsen M; Petersen RF; Wellendorph P; Frølund B
    Eur J Med Chem; 2017 Sep; 138():300-312. PubMed ID: 28683403
    [TBL] [Abstract][Full Text] [Related]  

  • 56. S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.
    Skoufias DA; DeBonis S; Saoudi Y; Lebeau L; Crevel I; Cross R; Wade RH; Hackney D; Kozielski F
    J Biol Chem; 2006 Jun; 281(26):17559-69. PubMed ID: 16507573
    [TBL] [Abstract][Full Text] [Related]  

  • 57. STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity.
    Indorato RL; DeBonis S; Kozielski F; Garcia-Saez I; Skoufias DA
    Biochem Pharmacol; 2013 Nov; 86(10):1441-51. PubMed ID: 24041742
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5.
    Gartner M; Sunder-Plassmann N; Seiler J; Utz M; Vernos I; Surrey T; Giannis A
    Chembiochem; 2005 Jul; 6(7):1173-7. PubMed ID: 15912555
    [No Abstract]   [Full Text] [Related]  

  • 59. Measuring kinesin's first step.
    Rosenfeld SS; Xing J; Jefferson GM; Cheung HC; King PH
    J Biol Chem; 2002 Sep; 277(39):36731-9. PubMed ID: 12122000
    [TBL] [Abstract][Full Text] [Related]  

  • 60. The role of Kinesin neck linker and neck in velocity regulation.
    Kalchishkova N; Böhm KJ
    J Mol Biol; 2008 Sep; 382(1):127-35. PubMed ID: 18640125
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.