BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 16439121)

  • 1. First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives.
    Provins L; Christophe B; Danhaive P; Dulieu J; Durieu V; Gillard M; Lebon F; Lengelé S; Quéré L; van Keulen B
    Bioorg Med Chem Lett; 2006 Apr; 16(7):1834-9. PubMed ID: 16439121
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives.
    Provins L; Christophe B; Danhaive P; Dulieu J; Gillard M; Quéré L; Stebbins K
    Bioorg Med Chem Lett; 2007 Jun; 17(11):3077-80. PubMed ID: 17398090
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2,1,3-Benzothiadiazine derivatives: synthesis and screening versus PDE4 enzyme.
    Tait A; Luppi A; Avallone R; Baraldi M
    Farmaco; 2005 Aug; 60(8):653-63. PubMed ID: 15963514
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.
    Starck JP; Provins L; Christophe B; Gillard M; Jadot S; Lo Brutto P; Quéré L; Talaga P; Guyaux M
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2675-8. PubMed ID: 18359633
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents.
    Van der Mey M; Bommelé KM; Boss H; Hatzelmann A; Van Slingerland M; Sterk GJ; Timmerman H
    J Med Chem; 2003 May; 46(10):2008-16. PubMed ID: 12723963
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.
    Kumar N; Kaur K; Aeron S; Dharmarajan S; Silamkoti AD; Mehta A; Gupta S; Chugh A; Gupta JB; Salman M; Palle VP; Cliffe IA
    Bioorg Med Chem Lett; 2007 Sep; 17(18):5256-60. PubMed ID: 17629699
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
    Vergne F; Bernardelli P; Lorthiois E; Pham N; Proust E; Oliveira C; Mafroud AK; Royer F; Wrigglesworth R; Schellhaas J; Barvian M; Moreau F; Idrissi M; Tertre A; Bertin B; Coupe M; Berna P; Soulard P
    Bioorg Med Chem Lett; 2004 Sep; 14(18):4607-13. PubMed ID: 15324874
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
    Macdonald D; Mastracchio A; Perrier H; Dubé D; Gallant M; Lacombe P; Deschênes D; Roy B; Scheigetz J; Bateman K; Li C; Trimble LA; Day S; Chauret N; Nicoll-Griffith DA; Silva JM; Huang Z; Laliberté F; Liu S; Ethier D; Pon D; Muise E; Boulet L; Chan CC; Styhler A; Charleson S; Mancini J; Masson P; Claveau D; Nicholson D; Turner M; Young RN; Girard Y
    Bioorg Med Chem Lett; 2005 Dec; 15(23):5241-6. PubMed ID: 16168647
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
    Pitts WJ; Vaccaro W; Huynh T; Leftheris K; Roberge JY; Barbosa J; Guo J; Brown B; Watson A; Donaldson K; Starling GC; Kiener PA; Poss MA; Dodd JH; Barrish JC
    Bioorg Med Chem Lett; 2004 Jun; 14(11):2955-8. PubMed ID: 15125967
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists.
    Sonda S; Katayama K; Fujio M; Sakashita H; Inaba K; Asano K; Akira T
    Bioorg Med Chem Lett; 2007 Feb; 17(4):925-31. PubMed ID: 17188867
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides.
    Anderson AJ; Nicholson JM; Bakare O; Butcher RJ; Wilson TL; Scott KR
    Bioorg Med Chem; 2006 Feb; 14(4):997-1006. PubMed ID: 16219468
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives.
    Ukita T; Sugahara M; Terakawa Y; Kuroda T; Wada K; Nakata A; Ohmachi Y; Kikkawa H; Ikezawa K; Naito K
    J Med Chem; 1999 Mar; 42(6):1088-99. PubMed ID: 10090791
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and characterization of novel classes of PDE10A inhibitors - 1H-1,3-benzodiazoles and imidazo[1,2-a]pyrimidines.
    Moszczyński-Pętkowski R; Majer J; Borkowska M; Bojarski Ł; Janowska S; Matłoka M; Stefaniak F; Smuga D; Bazydło K; Dubiel K; Wieczorek M
    Eur J Med Chem; 2018 Jul; 155():96-116. PubMed ID: 29870883
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
    Kempson J; Pitts WJ; Barbosa J; Guo J; Omotoso O; Watson A; Stebbins K; Starling GC; Dodd JH; Barrish JC; Felix R; Fischer K
    Bioorg Med Chem Lett; 2005 Apr; 15(7):1829-33. PubMed ID: 15780616
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.
    Bourguignon JJ; Désaubry L; Raboisson P; Wermuth CG; Lugnier C
    J Med Chem; 1997 Jun; 40(12):1768-70. PubMed ID: 9191951
    [No Abstract]   [Full Text] [Related]  

  • 16. Benzofuran based PDE4 inhibitors.
    McGarry DG; Regan JR; Volz FA; Hulme C; Moriarty KJ; Djuric SW; Souness JE; Miller BE; Travis JJ; Sweeney DM
    Bioorg Med Chem; 1999 Jun; 7(6):1131-9. PubMed ID: 10428384
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.
    Whitehead JW; Lee GP; Gharagozloo P; Hofer P; Gehrig A; Wintergerst P; Smyth D; McCoull W; Hachicha M; Patel A; Kyle DJ
    J Med Chem; 2005 Feb; 48(4):1237-43. PubMed ID: 15715490
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and synthesis of novel imidazo[1,2-a]quinoxalines as PDE4 inhibitors.
    Deleuze-Masquéfa C; Gerebtzoff G; Subra G; Fabreguettes JR; Ovens A; Carraz M; Strub MP; Bompart J; George P; Bonnet PA
    Bioorg Med Chem; 2004 Mar; 12(5):1129-39. PubMed ID: 14980625
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate.
    O'Shea PD; Chen CY; Chen W; Dagneau P; Frey LF; Grabowski EJ; Marcantonio KM; Reamer RA; Tan L; Tillyer RD; Roy A; Wang X; Zhao D
    J Org Chem; 2005 Apr; 70(8):3021-30. PubMed ID: 15822960
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.
    Naito R; Yonetoku Y; Okamoto Y; Toyoshima A; Ikeda K; Takeuchi M
    J Med Chem; 2005 Oct; 48(21):6597-606. PubMed ID: 16220976
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.