98 related articles for article (PubMed ID: 16439123)
1. Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Fraley ME; Garbaccio RM; Arrington KL; Hoffman WF; Tasber ES; Coleman PJ; Buser CA; Walsh ES; Hamilton K; Fernandes C; Schaber MD; Lobell RB; Tao W; South VJ; Yan Y; Kuo LC; Prueksaritanont T; Shu C; Torrent M; Heimbrook DC; Kohl NE; Huber HE; Hartman GD
Bioorg Med Chem Lett; 2006 Apr; 16(7):1775-9. PubMed ID: 16439123
[TBL] [Abstract][Full Text] [Related]
2. Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Garbaccio RM; Fraley ME; Tasber ES; Olson CM; Hoffman WF; Arrington KL; Torrent M; Buser CA; Walsh ES; Hamilton K; Schaber MD; Fernandes C; Lobell RB; Tao W; South VJ; Yan Y; Kuo LC; Prueksaritanont T; Slaughter DE; Shu C; Heimbrook DC; Kohl NE; Huber HE; Hartman GD
Bioorg Med Chem Lett; 2006 Apr; 16(7):1780-3. PubMed ID: 16439122
[TBL] [Abstract][Full Text] [Related]
3. Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.
Cox CD; Breslin MJ; Whitman DB; Coleman PJ; Garbaccio RM; Fraley ME; Zrada MM; Buser CA; Walsh ES; Hamilton K; Lobell RB; Tao W; Abrams MT; South VJ; Huber HE; Kohl NE; Hartman GD
Bioorg Med Chem Lett; 2007 May; 17(10):2697-702. PubMed ID: 17395460
[TBL] [Abstract][Full Text] [Related]
4. Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.
Cox CD; Breslin MJ; Mariano BJ; Coleman PJ; Buser CA; Walsh ES; Hamilton K; Huber HE; Kohl NE; Torrent M; Yan Y; Kuo LC; Hartman GD
Bioorg Med Chem Lett; 2005 Apr; 15(8):2041-5. PubMed ID: 15808464
[TBL] [Abstract][Full Text] [Related]
5. Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Roecker AJ; Coleman PJ; Mercer SP; Schreier JD; Buser CA; Walsh ES; Hamilton K; Lobell RB; Tao W; Diehl RE; South VJ; Davide JP; Kohl NE; Yan Y; Kuo LC; Li C; Fernandez-Metzler C; Mahan EA; Prueksaritanont T; Hartman GD
Bioorg Med Chem Lett; 2007 Oct; 17(20):5677-82. PubMed ID: 17766111
[TBL] [Abstract][Full Text] [Related]
6. Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Coleman PJ; Schreier JD; Cox CD; Fraley ME; Garbaccio RM; Buser CA; Walsh ES; Hamilton K; Lobell RB; Rickert K; Tao W; Diehl RE; South VJ; Davide JP; Kohl NE; Yan Y; Kuo L; Prueksaritanont T; Li C; Mahan EA; Fernandez-Metzler C; Salata JJ; Hartman GD
Bioorg Med Chem Lett; 2007 Oct; 17(19):5390-5. PubMed ID: 17761419
[TBL] [Abstract][Full Text] [Related]
7. Discovery of allosteric inhibitors of kinesin spindle protein (KSP) for the treatment of taxane-refractory cancer: MK-0731 and analogs.
Cox CD; Garbaccio RM
Anticancer Agents Med Chem; 2010 Nov; 10(9):697-712. PubMed ID: 21235439
[TBL] [Abstract][Full Text] [Related]
8. Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage.
Tao W; South VJ; Zhang Y; Davide JP; Farrell L; Kohl NE; Sepp-Lorenzino L; Lobell RB
Cancer Cell; 2005 Jul; 8(1):49-59. PubMed ID: 16023598
[TBL] [Abstract][Full Text] [Related]
9. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.
Liu F; Yu LQ; Jiang C; Yang L; Wu WT; You QD
Bioorg Med Chem; 2010 Jun; 18(12):4167-77. PubMed ID: 20537544
[TBL] [Abstract][Full Text] [Related]
10. Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
Cox CD; Torrent M; Breslin MJ; Mariano BJ; Whitman DB; Coleman PJ; Buser CA; Walsh ES; Hamilton K; Schaber MD; Lobell RB; Tao W; South VJ; Kohl NE; Yan Y; Kuo LC; Prueksaritanont T; Slaughter DE; Li C; Mahan E; Lu B; Hartman GD
Bioorg Med Chem Lett; 2006 Jun; 16(12):3175-9. PubMed ID: 16603356
[TBL] [Abstract][Full Text] [Related]
11. Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.
Takeuchi T; Oishi S; Kaneda M; Misu R; Ohno H; Sawada J; Asai A; Nakamura S; Nakanishi I; Fujii N
Bioorg Med Chem; 2014 Jun; 22(12):3171-9. PubMed ID: 24794744
[TBL] [Abstract][Full Text] [Related]
12. Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
Cox CD; Coleman PJ; Breslin MJ; Whitman DB; Garbaccio RM; Fraley ME; Buser CA; Walsh ES; Hamilton K; Schaber MD; Lobell RB; Tao W; Davide JP; Diehl RE; Abrams MT; South VJ; Huber HE; Torrent M; Prueksaritanont T; Li C; Slaughter DE; Mahan E; Fernandez-Metzler C; Yan Y; Kuo LC; Kohl NE; Hartman GD
J Med Chem; 2008 Jul; 51(14):4239-52. PubMed ID: 18578472
[TBL] [Abstract][Full Text] [Related]
13. Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.
Matsuno K; Sawada J; Sugimoto M; Ogo N; Asai A
Bioorg Med Chem Lett; 2009 Feb; 19(4):1058-61. PubMed ID: 19167222
[TBL] [Abstract][Full Text] [Related]
14. Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.
Mansoor UF; Angeles AR; Dai C; Yang L; Vitharana D; Basso AD; Gray K; Tang H; Liu M; Liang L; Allbritton O; Siddiqui MA
Bioorg Med Chem; 2015 May; 23(10):2424-34. PubMed ID: 25868746
[TBL] [Abstract][Full Text] [Related]
15. Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.
Luo L; Carson JD; Molnar KS; Tuske SJ; Coales SJ; Hamuro Y; Sung CM; Sudakin V; Auger KR; Dhanak D; Jackson JR; Huang PS; Tummino PJ; Copeland RA
J Am Chem Soc; 2008 Jun; 130(24):7584-91. PubMed ID: 18491908
[TBL] [Abstract][Full Text] [Related]
16. Developments of kinesin spindle protein inhibitors as antitumor agents based on the five-membered heterocycle scaffolds.
Zhao GD; Wan RZ; Liu ZP
Curr Med Chem; 2014; 21(23):2691-701. PubMed ID: 24606497
[TBL] [Abstract][Full Text] [Related]
17. Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.
Garbaccio RM; Tasber ES; Neilson LA; Coleman PJ; Fraley ME; Olson C; Bergman J; Torrent M; Buser CA; Rickert K; Walsh ES; Hamilton K; Lobell RB; Tao W; South VJ; Diehl RE; Davide JP; Yan Y; Kuo LC; Li C; Prueksaritanont T; Fernandez-Metzler C; Mahan EA; Slaughter DE; Salata JJ; Kohl NE; Huber HE; Hartman GD
Bioorg Med Chem Lett; 2007 Oct; 17(20):5671-6. PubMed ID: 17804233
[TBL] [Abstract][Full Text] [Related]
18. Progress on kinesin spindle protein inhibitors as anti-cancer agents.
Zhang Y; Xu W
Anticancer Agents Med Chem; 2008 Aug; 8(6):698-704. PubMed ID: 18690830
[TBL] [Abstract][Full Text] [Related]
19. Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.
Oishi S; Watanabe T; Sawada J; Asai A; Ohno H; Fujii N
J Med Chem; 2010 Jul; 53(13):5054-8. PubMed ID: 20521839
[TBL] [Abstract][Full Text] [Related]
20. An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis.
Tao W; South VJ; Diehl RE; Davide JP; Sepp-Lorenzino L; Fraley ME; Arrington KL; Lobell RB
Mol Cell Biol; 2007 Jan; 27(2):689-98. PubMed ID: 17101792
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
