105 related articles for article (PubMed ID: 16439124)
1. Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.
Nair V; Uchil V; Neamati N
Bioorg Med Chem Lett; 2006 Apr; 16(7):1920-3. PubMed ID: 16439124
[TBL] [Abstract][Full Text] [Related]
2. Biologically-validated HIV integrase inhibitors with nucleobase scaffolds: structure, synthesis, chemical biology, molecular modeling, and antiviral activity.
Nair V; Uchil V; Chi G; Dams I; Cox A; Seo B
Nucleosides Nucleotides Nucleic Acids; 2007; 26(6-7):665-8. PubMed ID: 18066876
[TBL] [Abstract][Full Text] [Related]
3. HIV integrase inhibitors as therapeutic agents in AIDS.
Nair V; Chi G
Rev Med Virol; 2007; 17(4):277-95. PubMed ID: 17503547
[TBL] [Abstract][Full Text] [Related]
4. HIV type 1 integrase inhibitors: from basic research to clinical implications.
Jegede O; Babu J; Di Santo R; McColl DJ; Weber J; Quiñones-Mateu M
AIDS Rev; 2008; 10(3):172-89. PubMed ID: 18820719
[TBL] [Abstract][Full Text] [Related]
5. Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.
Sechi M; Derudas M; Dallocchio R; Dessì A; Bacchi A; Sannia L; Carta F; Palomba M; Ragab O; Chan C; Shoemaker R; Sei S; Dayam R; Neamati N
J Med Chem; 2004 Oct; 47(21):5298-310. PubMed ID: 15456274
[TBL] [Abstract][Full Text] [Related]
6. Beta-diketo acid pharmacophore hypothesis. 1. Discovery of a novel class of HIV-1 integrase inhibitors.
Dayam R; Sanchez T; Clement O; Shoemaker R; Sei S; Neamati N
J Med Chem; 2005 Jan; 48(1):111-20. PubMed ID: 15634005
[TBL] [Abstract][Full Text] [Related]
7. Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.
Dayam R; Sanchez T; Neamati N
J Med Chem; 2005 Dec; 48(25):8009-15. PubMed ID: 16335925
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors.
Li X; Vince R
Bioorg Med Chem; 2006 Aug; 14(16):5742-55. PubMed ID: 16753300
[TBL] [Abstract][Full Text] [Related]
9. De novo design and synthesis of HIV-1 integrase inhibitors.
Makhija MT; Kasliwal RT; Kulkarni VM; Neamati N
Bioorg Med Chem; 2004 May; 12(9):2317-33. PubMed ID: 15080929
[TBL] [Abstract][Full Text] [Related]
10. New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors.
Ferro S; Barreca ML; De Luca L; Rao A; Monforte AM; Debyser Z; Witvrouw M; Chimirri A
Arch Pharm (Weinheim); 2007 Jun; 340(6):292-8. PubMed ID: 17562561
[TBL] [Abstract][Full Text] [Related]
11. Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Barreca ML; Ferro S; Rao A; De Luca L; Zappalà M; Monforte AM; Debyser Z; Witvrouw M; Chimirri A
J Med Chem; 2005 Nov; 48(22):7084-8. PubMed ID: 16250669
[TBL] [Abstract][Full Text] [Related]
12. A novel strategy to assemble the beta-diketo acid pharmacophore of HIV integrase inhibitors on purine nucleobase scaffolds.
Uchil V; Seo B; Nair V
J Org Chem; 2007 Oct; 72(22):8577-9. PubMed ID: 17918897
[TBL] [Abstract][Full Text] [Related]
13. Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors.
Plewe MB; Butler SL; Dress KR; Hu Q; Johnson TW; Kuehler JE; Kuki A; Lam H; Liu W; Nowlin D; Peng Q; Rahavendran SV; Tanis SP; Tran KT; Wang H; Yang A; Zhang J
J Med Chem; 2009 Nov; 52(22):7211-9. PubMed ID: 19873974
[TBL] [Abstract][Full Text] [Related]
14. Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
Gardelli C; Nizi E; Muraglia E; Crescenzi B; Ferrara M; Orvieto F; Pace P; Pescatore G; Poma M; Ferreira Mdel R; Scarpelli R; Homnick CF; Ikemoto N; Alfieri A; Verdirame M; Bonelli F; Paz OG; Taliani M; Monteagudo E; Pesci S; Laufer R; Felock P; Stillmock KA; Hazuda D; Rowley M; Summa V
J Med Chem; 2007 Oct; 50(20):4953-75. PubMed ID: 17824681
[TBL] [Abstract][Full Text] [Related]
15. Conformationally restrained carbazolone-containing alpha,gamma-diketo acids as inhibitors of HIV integrase.
Li X; Vince R
Bioorg Med Chem; 2006 May; 14(9):2942-55. PubMed ID: 16386908
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis, and anti-integrase activity of catechol-DKA hybrids.
Maurin C; Bailly F; Mbemba G; Mouscadet JF; Cotelle P
Bioorg Med Chem; 2006 May; 14(9):2978-84. PubMed ID: 16412645
[TBL] [Abstract][Full Text] [Related]
17. HIV-1 integrase inhibitors: 2003-2004 update.
Dayam R; Deng J; Neamati N
Med Res Rev; 2006 May; 26(3):271-309. PubMed ID: 16496343
[TBL] [Abstract][Full Text] [Related]
18. Discovery and structure-activity relationship studies of a unique class of HIV-1 integrase inhibitors.
Dayam R; Sanchez T; Neamati N
ChemMedChem; 2006 Feb; 1(2):238-44. PubMed ID: 16892356
[TBL] [Abstract][Full Text] [Related]
19. A quantum mechanics/molecular mechanics study of the protein-ligand interaction for inhibitors of HIV-1 integrase.
Alves CN; Martí S; Castillo R; Andrés J; Moliner V; Tuñón I; Silla E
Chemistry; 2007; 13(27):7715-24. PubMed ID: 17570717
[TBL] [Abstract][Full Text] [Related]
20. Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase.
Barreca ML; De Luca L; Iraci N; Chimirri A
J Med Chem; 2006 Jun; 49(13):3994-7. PubMed ID: 16789757
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
