201 related articles for article (PubMed ID: 16446806)
1. Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Ohkanda J; Strickland CL; Blaskovich MA; Carrico D; Lockman JW; Vogt A; Bucher CJ; Sun J; Qian Y; Knowles D; Pusateri EE; Sebti SM; Hamilton AD
Org Biomol Chem; 2006 Feb; 4(3):482-92. PubMed ID: 16446806
[TBL] [Abstract][Full Text] [Related]
2. Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Vasudevan A; Qian Y; Vogt A; Blaskovich MA; Ohkanda J; Sebti SM; Hamilton AD
J Med Chem; 1999 Apr; 42(8):1333-40. PubMed ID: 10212118
[TBL] [Abstract][Full Text] [Related]
3. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Ohkanda J; Buckner FS; Lockman JW; Yokoyama K; Carrico D; Eastman R; de Luca-Fradley K; Davies W; Croft SL; Van Voorhis WC; Gelb MH; Sebti SM; Hamilton AD
J Med Chem; 2004 Jan; 47(2):432-45. PubMed ID: 14711313
[TBL] [Abstract][Full Text] [Related]
4. Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Bolchi C; Pallavicini M; Bernini SK; Chiodini G; Corsini A; Ferri N; Fumagalli L; Straniero V; Valoti E
Bioorg Med Chem Lett; 2011 Sep; 21(18):5408-12. PubMed ID: 21802946
[TBL] [Abstract][Full Text] [Related]
5. Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase.
Coudray L; de Figueiredo RM; Duez S; Cortial S; Dubois J
J Enzyme Inhib Med Chem; 2009 Aug; 24(4):972-85. PubMed ID: 19555171
[TBL] [Abstract][Full Text] [Related]
6. Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials.
Kohring K; Wiesner J; Altenkämper M; Sakowski J; Silber K; Hillebrecht A; Haebel P; Dahse HM; Ortmann R; Jomaa H; Klebe G; Schlitzer M
ChemMedChem; 2008 Aug; 3(8):1217-31. PubMed ID: 18470859
[TBL] [Abstract][Full Text] [Related]
7. Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.
Gilleron P; Millet R; Houssin R; Wlodarczyk N; Farce A; Lemoine A; Goossens JF; Chavatte P; Pommery N; Hénichart JP
Eur J Med Chem; 2006 Jun; 41(6):745-55. PubMed ID: 16647166
[TBL] [Abstract][Full Text] [Related]
8. Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc.
Huang CY; Stauffer TM; Strickland CL; Reader JC; Huang H; Li G; Cooper AB; Doll RJ; Ganguly AK; Baldwin JJ; Rokosz LL
Bioorg Med Chem Lett; 2006 Feb; 16(3):507-11. PubMed ID: 16289818
[TBL] [Abstract][Full Text] [Related]
9. Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.
Douty B; Wayland B; Ala PJ; Bower MJ; Pruitt J; Bostrom L; Wei M; Klabe R; Gonneville L; Wynn R; Burn TC; Liu PC; Combs AP; Yue EW
Bioorg Med Chem Lett; 2008 Jan; 18(1):66-71. PubMed ID: 18037290
[TBL] [Abstract][Full Text] [Related]
10. Discovery of C-imidazole azaheptapyridine FPT inhibitors.
Zhu HY; Cooper AB; Desai J; Njoroge G; Kirschmeier P; Bishop WR; Strickland C; Hruza A; Doll RJ; Girijavallabhan VM
Bioorg Med Chem Lett; 2010 Feb; 20(3):1134-6. PubMed ID: 20056542
[TBL] [Abstract][Full Text] [Related]
11. 3D-QSAR with the aid of pharmacophore search and docking-based alignments for farnesyltransferase inhibitors.
Vaidya M; Weigt M; Wiese M
Eur J Med Chem; 2009 Oct; 44(10):4070-82. PubMed ID: 19515462
[TBL] [Abstract][Full Text] [Related]
12. Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode.
Finlay MR; Acton DG; Andrews DM; Barker AJ; Dennis M; Fisher E; Graham MA; Green CP; Heaton DW; Karoutchi G; Loddick SA; Morgentin R; Roberts A; Tucker JA; Weir HM
Bioorg Med Chem Lett; 2008 Aug; 18(15):4442-6. PubMed ID: 18617397
[TBL] [Abstract][Full Text] [Related]
13. New asymmetric synthesis of protein farnesyltransferase inhibitors via palladium-catalyzed cross-coupling reactions of 2-iodo-imidazoles.
Kerhervé J; Botuha C; Dubois J
Org Biomol Chem; 2009 May; 7(10):2214-22. PubMed ID: 19421463
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.
Carrico D; Blaskovich MA; Bucher CJ; Sebti SM; Hamilton AD
Bioorg Med Chem; 2005 Feb; 13(3):677-88. PubMed ID: 15653335
[TBL] [Abstract][Full Text] [Related]
15. Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor.
Kadono S; Sakamoto A; Kikuchi Y; Oh-eda M; Yabuta N; Yoshihashi K; Kitazawa T; Suzuki T; Koga T; Hattori K; Shiraishi T; Haramura M; Kodama H; Ono Y; Esaki T; Sato H; Watanabe Y; Itoh S; Ohta M; Kozono T
Biochem Biophys Res Commun; 2005 Feb; 327(2):589-96. PubMed ID: 15629154
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.
Lombardo LJ; Camuso A; Clark J; Fager K; Gullo-Brown J; Hunt JT; Inigo I; Kan D; Koplowitz B; Lee F; McGlinchey K; Qian L; Ricca C; Rovnyak G; Traeger S; Tokarski J; Williams DK; Wu LI; Zhao Y; Manne V; Bhide RS
Bioorg Med Chem Lett; 2005 Apr; 15(7):1895-9. PubMed ID: 15780629
[TBL] [Abstract][Full Text] [Related]
17. IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.
Buckley GM; Ceska TA; Fraser JL; Gowers L; Groom CR; Higueruelo AP; Jenkins K; Mack SR; Morgan T; Parry DM; Pitt WR; Rausch O; Richard MD; Sabin V
Bioorg Med Chem Lett; 2008 Jun; 18(11):3291-5. PubMed ID: 18482836
[TBL] [Abstract][Full Text] [Related]
18. YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model.
Shindoh N; Mori M; Terada Y; Oda K; Amino N; Kita A; Taniguchi M; Sohda KY; Nagai K; Sowa Y; Masuoka Y; Orita M; Sasamata M; Matsushime H; Furuichi K; Sakai T
Int J Oncol; 2008 Mar; 32(3):545-55. PubMed ID: 18292931
[TBL] [Abstract][Full Text] [Related]
19. Modeling of farnesyltransferase inhibition by some thiol and non-thiol peptidomimetic inhibitors using genetic neural networks and RDF approaches.
González MP; Caballero J; Tundidor-Camba A; Helguera AM; Fernández M
Bioorg Med Chem; 2006 Jan; 14(1):200-13. PubMed ID: 16185882
[TBL] [Abstract][Full Text] [Related]
20. Conformationally restricted hydantoin-based peptidomimetics as inhibitors of caspase-3 with basic groups allowed at the S3 enzyme subsite.
Vázquez J; García-Jareño A; Mondragón L; Rubio-Martinez J; Pérez-Payá E; Albericio F
ChemMedChem; 2008 Jun; 3(6):979-85. PubMed ID: 18393268
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
