BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 16451058)

  • 1. Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.
    Pochetti G; Gavuzzo E; Campestre C; Agamennone M; Tortorella P; Consalvi V; Gallina C; Hiller O; Tschesche H; Tucker PA; Mazza F
    J Med Chem; 2006 Feb; 49(3):923-31. PubMed ID: 16451058
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations.
    Aschi M; Besker N; Re N; Pochetti G; Coletti C; Gallina C; Mazza F
    J Med Chem; 2007 Jan; 50(2):211-8. PubMed ID: 17228863
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2.
    Agamennone M; Campestre C; Preziuso S; Consalvi V; Crucianelli M; Mazza F; Politi V; Ragno R; Tortorella P; Gallina C
    Eur J Med Chem; 2005 Mar; 40(3):271-9. PubMed ID: 15725496
    [TBL] [Abstract][Full Text] [Related]  

  • 4. N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8.
    Campestre C; Agamennone M; Tortorella P; Preziuso S; Biasone A; Gavuzzo E; Pochetti G; Mazza F; Hiller O; Tschesche H; Consalvi V; Gallina C
    Bioorg Med Chem Lett; 2006 Jan; 16(1):20-4. PubMed ID: 16242329
    [TBL] [Abstract][Full Text] [Related]  

  • 5. alpha-Biphenylsulfonylamino 2-methylpropyl phosphonates: enantioselective synthesis and selective inhibition of MMPs.
    Biasone A; Tortorella P; Campestre C; Agamennone M; Preziuso S; Chiappini M; Nuti E; Carelli P; Rossello A; Mazza F; Gallina C
    Bioorg Med Chem; 2007 Jan; 15(2):791-9. PubMed ID: 17088065
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Extra binding region induced by non-zinc chelating inhibitors into the S1' subsite of matrix metalloproteinase 8 (MMP-8).
    Pochetti G; Montanari R; Gege C; Chevrier C; Taveras AG; Mazza F
    J Med Chem; 2009 Feb; 52(4):1040-9. PubMed ID: 19173605
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, SAR, and biological evaluation of alpha-sulfonylphosphonic acids as selective matrix metalloproteinase inhibitors.
    Rubino MT; Agamennone M; Campestre C; Fracchiolla G; Laghezza A; Loiodice F; Nuti E; Rossello A; Tortorella P
    ChemMedChem; 2009 Mar; 4(3):352-62. PubMed ID: 19204958
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.
    Tuccinardi T; Martinelli A; Nuti E; Carelli P; Balzano F; Uccello-Barretta G; Murphy G; Rossello A
    Bioorg Med Chem; 2006 Jun; 14(12):4260-76. PubMed ID: 16483784
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
    Cherney RJ; Mo R; Meyer DT; Hardman KD; Liu RQ; Covington MB; Qian M; Wasserman ZR; Christ DD; Trzaskos JM; Newton RC; Decicco CP
    J Med Chem; 2004 Jun; 47(12):2981-3. PubMed ID: 15163180
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of dog and human gastric lipases by enantiomeric phosphonate inhibitors: a structure-activity study.
    Miled N; Roussel A; Bussetta C; Berti-Dupuis L; Rivière M; Buono G; Verger R; Cambillau C; Canaan S
    Biochemistry; 2003 Oct; 42(40):11587-93. PubMed ID: 14529268
    [TBL] [Abstract][Full Text] [Related]  

  • 11. QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase.
    Jamloki A; Karthikeyan C; Hari Narayana Moorthy NS; Trivedi P
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3847-54. PubMed ID: 16682189
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis for the highly selective inhibition of MMP-13.
    Engel CK; Pirard B; Schimanski S; Kirsch R; Habermann J; Klingler O; Schlotte V; Weithmann KU; Wendt KU
    Chem Biol; 2005 Feb; 12(2):181-9. PubMed ID: 15734645
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pyrimidine-2,4,6-Triones: a new effective and selective class of matrix metalloproteinase inhibitors.
    Grams F; Brandstetter H; D'Alò S; Geppert D; Krell HW; Leinert H; Livi V; Menta E; Oliva A; Zimmermann G; Gram F; Brandstetter H; D'Alò S; Geppert D; Krell HW; Leinert H; Livi VMenta E; Oliva A; Zimmermann G
    Biol Chem; 2001 Aug; 382(8):1277-85. PubMed ID: 11592410
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A novel series of highly selective inhibitors of MMP-3.
    Whitlock GA; Dack KN; Dickinson RP; Lewis ML
    Bioorg Med Chem Lett; 2007 Dec; 17(24):6750-3. PubMed ID: 18029177
    [TBL] [Abstract][Full Text] [Related]  

  • 15. N-O-isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors.
    Santamaria S; Nuti E; Cercignani G; Marinelli L; La Pietra V; Novellino E; Rossello A
    Biochem Pharmacol; 2012 Sep; 84(6):813-20. PubMed ID: 22771631
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.
    Brandstetter H; Engh RA; Von Roedern EG; Moroder L; Huber R; Bode W; Grams F
    Protein Sci; 1998 Jun; 7(6):1303-9. PubMed ID: 9655333
    [TBL] [Abstract][Full Text] [Related]  

  • 17. X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.
    Pavlovsky AG; Williams MG; Ye QZ; Ortwine DF; Purchase CF; White AD; Dhanaraj V; Roth BD; Johnson LL; Hupe D; Humblet C; Blundell TL
    Protein Sci; 1999 Jul; 8(7):1455-62. PubMed ID: 10422833
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Carbamoylphosphonates, a new class of in vivo active matrix metalloproteinase inhibitors. 1. Alkyl- and cycloalkylcarbamoylphosphonic acids.
    Breuer E; Salomon CJ; Katz Y; Chen W; Lu S; Röschenthaler GV; Hadar R; Reich R
    J Med Chem; 2004 May; 47(11):2826-32. PubMed ID: 15139760
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.
    Dublanchet AC; Ducrot P; Andrianjara C; O'Gara M; Morales R; Compère D; Denis A; Blais S; Cluzeau P; Courté K; Hamon J; Moreau F; Prunet ML; Tertre A
    Bioorg Med Chem Lett; 2005 Aug; 15(16):3787-90. PubMed ID: 16002291
    [TBL] [Abstract][Full Text] [Related]  

  • 20. QSAR-by-NMR: quantitative insights into structural determinants for binding affinity by analysis of 1H/15N chemical shift differences in MMP-3 ligands.
    Matter H; Schudok M; Elshorst B; Jacobs DM; Saxena K; Kogler H
    Bioorg Med Chem Lett; 2005 Apr; 15(7):1779-83. PubMed ID: 15780605
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.