260 related articles for article (PubMed ID: 16453348)
1. Broad substrate specificity of ketoreductases derived from modular polyketide synthases.
Bali S; O'Hare HM; Weissman KJ
Chembiochem; 2006 Mar; 7(3):478-84. PubMed ID: 16453348
[TBL] [Abstract][Full Text] [Related]
2. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.
O'Hare HM; Baerga-Ortiz A; Popovic B; Spencer JB; Leadlay PF
Chem Biol; 2006 Mar; 13(3):287-96. PubMed ID: 16638534
[TBL] [Abstract][Full Text] [Related]
3. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.
Baerga-Ortiz A; Popovic B; Siskos AP; O'Hare HM; Spiteller D; Williams MG; Campillo N; Spencer JB; Leadlay PF
Chem Biol; 2006 Mar; 13(3):277-85. PubMed ID: 16638533
[TBL] [Abstract][Full Text] [Related]
4. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.
Siskos AP; Baerga-Ortiz A; Bali S; Stein V; Mamdani H; Spiteller D; Popovic B; Spencer JB; Staunton J; Weissman KJ; Leadlay PF
Chem Biol; 2005 Oct; 12(10):1145-53. PubMed ID: 16242657
[TBL] [Abstract][Full Text] [Related]
5. Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro.
Bali S; Weissman KJ
Chembiochem; 2006 Dec; 7(12):1935-42. PubMed ID: 17031885
[TBL] [Abstract][Full Text] [Related]
6. A polylinker approach to reductive loop swaps in modular polyketide synthases.
Kellenberger L; Galloway IS; Sauter G; Böhm G; Hanefeld U; Cortés J; Staunton J; Leadlay PF
Chembiochem; 2008 Nov; 9(16):2740-9. PubMed ID: 18937219
[TBL] [Abstract][Full Text] [Related]
7. Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases.
Zheng J; Keatinge-Clay AT
J Mol Biol; 2011 Jul; 410(1):105-17. PubMed ID: 21570406
[TBL] [Abstract][Full Text] [Related]
8. Autonomous folding of interdomain regions of a modular polyketide synthase.
Richter CD; Stanmore DA; Miguel RN; Moncrieffe MC; Tran L; Brewerton S; Meersman F; Broadhurst RW; Weissman KJ
FEBS J; 2007 May; 274(9):2196-209. PubMed ID: 17419733
[TBL] [Abstract][Full Text] [Related]
9. Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase.
Petković H; Sandmann A; Challis IR; Hecht HJ; Silakowski B; Low L; Beeston N; Kuscer E; Garcia-Bernardo J; Leadlay PF; Kendrew SG; Wilkinson B; Müller R
Org Biomol Chem; 2008 Feb; 6(3):500-6. PubMed ID: 18219420
[TBL] [Abstract][Full Text] [Related]
10. Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry.
Annaval T; Paris C; Leadlay PF; Jacob C; Weissman KJ
Chembiochem; 2015 Jun; 16(9):1357-64. PubMed ID: 25851784
[TBL] [Abstract][Full Text] [Related]
11. Site-Directed Mutagenesis of Modular Polyketide Synthase Ketoreductase Domains for Altered Stereochemical Control.
Drufva EE; Spengler NR; Hix EG; Bailey CB
Chembiochem; 2021 Apr; 22(7):1122-1150. PubMed ID: 33185924
[TBL] [Abstract][Full Text] [Related]
12. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase.
Kim CY; Alekseyev VY; Chen AY; Tang Y; Cane DE; Khosla C
Biochemistry; 2004 Nov; 43(44):13892-8. PubMed ID: 15518537
[TBL] [Abstract][Full Text] [Related]
13. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.
Reid R; Piagentini M; Rodriguez E; Ashley G; Viswanathan N; Carney J; Santi DV; Hutchinson CR; McDaniel R
Biochemistry; 2003 Jan; 42(1):72-9. PubMed ID: 12515540
[TBL] [Abstract][Full Text] [Related]
14. Insights into the programmed ketoreduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain.
Soehano I; Yang L; Ding F; Sun H; Low ZJ; Liu X; Liang ZX
Org Biomol Chem; 2014 Nov; 12(42):8542-9. PubMed ID: 25238086
[TBL] [Abstract][Full Text] [Related]
15. The toxic dinoflagellate Karenia brevis encodes novel type I-like polyketide synthases containing discrete catalytic domains.
Monroe EA; Van Dolah FM
Protist; 2008 Jul; 159(3):471-82. PubMed ID: 18467171
[TBL] [Abstract][Full Text] [Related]
16. Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.
Kwan DH; Sun Y; Schulz F; Hong H; Popovic B; Sim-Stark JC; Haydock SF; Leadlay PF
Chem Biol; 2008 Nov; 15(11):1231-40. PubMed ID: 19022183
[TBL] [Abstract][Full Text] [Related]
17. Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
Liu C; Yuan M; Xu X; Wang L; Keatinge-Clay AT; Deng Z; Lin S; Zheng J
J Struct Biol; 2018 Aug; 203(2):135-141. PubMed ID: 29626512
[TBL] [Abstract][Full Text] [Related]
18. The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.
Keatinge-Clay AT; Stroud RM
Structure; 2006 Apr; 14(4):737-48. PubMed ID: 16564177
[TBL] [Abstract][Full Text] [Related]
19. Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity.
Kwan DH; Leadlay PF
ACS Chem Biol; 2010 Sep; 5(9):829-38. PubMed ID: 20666435
[TBL] [Abstract][Full Text] [Related]
20. Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks.
Piasecki SK; Taylor CA; Detelich JF; Liu J; Zheng J; Komsoukaniants A; Siegel DR; Keatinge-Clay AT
Chem Biol; 2011 Oct; 18(10):1331-40. PubMed ID: 22035802
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]