564 related articles for article (PubMed ID: 16458008)
1. Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and 3D-QSAR analyses on DHDMBF analogues.
Zheng M; Zhang Z; Zhu W; Liu H; Luo X; Chen K; Jiang H
Bioorg Med Chem; 2006 May; 14(10):3428-37. PubMed ID: 16458008
[TBL] [Abstract][Full Text] [Related]
2. Rationalization of physicochemical characters of 1,5-diarylpyrazole analogs as dual (COX-2/LOX-5) inhibitors: a QSAR approach.
Revathi S; Gupta AK; Soni LK; Kavitha S; Wagh R; Kaskhedikar SG
J Pharm Biomed Anal; 2006 Sep; 42(2):283-9. PubMed ID: 16781106
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
J Med Chem; 2006 Mar; 49(5):1668-83. PubMed ID: 16509583
[TBL] [Abstract][Full Text] [Related]
4. Enzyme selectivity of new cyclooxygenase-2/5 lipoxygenase inhibitors using molecular modeling approach.
Kothekar V; Sahi S; Mishra J
Indian J Biochem Biophys; 2000 Apr; 37(2):86-96. PubMed ID: 10983419
[TBL] [Abstract][Full Text] [Related]
5. New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
Janusz JM; Young PA; Ridgeway JM; Scherz MW; Enzweiler K; Wu LI; Gan L; Chen J; Kellstein DE; Green SA; Tulich JL; Rosario-Jansen T; Magrisso IJ; Wehmeyer KR; Kuhlenbeck DL; Eichhold TH; Dobson RL
J Med Chem; 1998 Aug; 41(18):3515-29. PubMed ID: 9719605
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
Cusan C; Spalluto G; Prato M; Adams M; Bodensieck A; Bauer R; Tubaro A; Bernardi P; Da Ros T
Farmaco; 2005 Apr; 60(4):327-32. PubMed ID: 15848208
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
Özadalı K; Özkanlı F; Jain S; Rao PP; Velázquez-Martínez CA
Bioorg Med Chem; 2012 May; 20(9):2912-22. PubMed ID: 22475926
[TBL] [Abstract][Full Text] [Related]
8. Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
Tan CM; Chen GS; Chen CS; Chang PT; Chern JW
Bioorg Med Chem; 2011 Nov; 19(21):6316-28. PubMed ID: 21958737
[TBL] [Abstract][Full Text] [Related]
9. Binding investigation of human 5-lipoxygenase with its inhibitors by SPR technology correlating with molecular docking simulation.
Du L; Zhang Z; Luo X; Chen K; Shen X; Jiang H
J Biochem; 2006 Apr; 139(4):715-23. PubMed ID: 16672272
[TBL] [Abstract][Full Text] [Related]
10. Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.
Chen CS; Tan CM; Huang CH; Chang LC; Wang JP; Cheng FC; Chern JW
Bioorg Med Chem; 2010 Jan; 18(2):597-604. PubMed ID: 20056549
[TBL] [Abstract][Full Text] [Related]
11. Genome wide analysis and comparative docking studies of new diaryl furan derivatives against human cyclooxygenase-2, lipoxygenase, thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway.
Sekhar PN; Reddy LA; De Maeyer M; Kumar KP; Srinivasulu YS; Sunitha MS; Sphoorthi IS; Jayasree G; Rao AM; Kothekar VS; Narayana PV; Kishor PB
J Mol Graph Model; 2009 Nov; 28(4):313-29. PubMed ID: 19766029
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
Reddy MV; Billa VK; Pallela VR; Mallireddigari MR; Boominathan R; Gabriel JL; Reddy EP
Bioorg Med Chem; 2008 Apr; 16(7):3907-16. PubMed ID: 18272371
[TBL] [Abstract][Full Text] [Related]
13. New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.
Janusz JM; Young PA; Scherz MW; Enzweiler K; Wu LI; Gan L; Pikul S; McDow-Dunham KL; Johnson CR; Senanayake CB; Kellstein DE; Green SA; Tulich JL; Rosario-Jansen T; Magrisso IJ; Wehmeyer KR; Kuhlenbeck DL; Eichhold TH; Dobson RL
J Med Chem; 1998 Mar; 41(7):1124-37. PubMed ID: 9544212
[TBL] [Abstract][Full Text] [Related]
14. Computer-aided discovery of anti-inflammatory thiazolidinones with dual cyclooxygenase/lipoxygenase inhibition.
Geronikaki AA; Lagunin AA; Hadjipavlou-Litina DI; Eleftheriou PT; Filimonov DA; Poroikov VV; Alam I; Saxena AK
J Med Chem; 2008 Mar; 51(6):1601-9. PubMed ID: 18311898
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
Chen QH; Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7898-909. PubMed ID: 16904331
[TBL] [Abstract][Full Text] [Related]
16. Binding interaction analysis of the active site and its inhibitors for neuraminidase (N1 subtype) of human influenza virus by the integration of molecular docking, FMO calculation and 3D-QSAR CoMFA modeling.
Zhang Q; Yang J; Liang K; Feng L; Li S; Wan J; Xu X; Yang G; Liu D; Yang S
J Chem Inf Model; 2008 Sep; 48(9):1802-12. PubMed ID: 18707092
[TBL] [Abstract][Full Text] [Related]
17. 3D-QSAR and docking studies of aldehyde inhibitors of human cathepsin K.
Pan X; Tan N; Zeng G; Han H; Huang H
Bioorg Med Chem; 2006 Apr; 14(8):2771-8. PubMed ID: 16377193
[TBL] [Abstract][Full Text] [Related]
18. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.
Li Y; Chen SH; Ou TM; Tan JH; Li D; Gu LQ; Huang ZS
Bioorg Med Chem; 2011 Mar; 19(6):2074-83. PubMed ID: 21349729
[TBL] [Abstract][Full Text] [Related]
19. Molecular docking and 3D QSAR studies on 1-amino-2-phenyl-4-(piperidin-1-yl)-butanes based on the structural modeling of human CCR5 receptor.
Xu Y; Liu H; Niu C; Luo C; Luo X; Shen J; Chen K; Jiang H
Bioorg Med Chem; 2004 Dec; 12(23):6193-208. PubMed ID: 15519163
[TBL] [Abstract][Full Text] [Related]
20. Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase.
Zuo Z; Luo X; Zhu W; Shen J; Shen X; Jiang H; Chen K
Bioorg Med Chem; 2005 Mar; 13(6):2121-31. PubMed ID: 15727865
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
