These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

562 related articles for article (PubMed ID: 16458008)

  • 1. Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and 3D-QSAR analyses on DHDMBF analogues.
    Zheng M; Zhang Z; Zhu W; Liu H; Luo X; Chen K; Jiang H
    Bioorg Med Chem; 2006 May; 14(10):3428-37. PubMed ID: 16458008
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rationalization of physicochemical characters of 1,5-diarylpyrazole analogs as dual (COX-2/LOX-5) inhibitors: a QSAR approach.
    Revathi S; Gupta AK; Soni LK; Kavitha S; Wagh R; Kaskhedikar SG
    J Pharm Biomed Anal; 2006 Sep; 42(2):283-9. PubMed ID: 16781106
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
    Rao PN; Chen QH; Knaus EE
    J Med Chem; 2006 Mar; 49(5):1668-83. PubMed ID: 16509583
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Enzyme selectivity of new cyclooxygenase-2/5 lipoxygenase inhibitors using molecular modeling approach.
    Kothekar V; Sahi S; Mishra J
    Indian J Biochem Biophys; 2000 Apr; 37(2):86-96. PubMed ID: 10983419
    [TBL] [Abstract][Full Text] [Related]  

  • 5. New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
    Janusz JM; Young PA; Ridgeway JM; Scherz MW; Enzweiler K; Wu LI; Gan L; Chen J; Kellstein DE; Green SA; Tulich JL; Rosario-Jansen T; Magrisso IJ; Wehmeyer KR; Kuhlenbeck DL; Eichhold TH; Dobson RL
    J Med Chem; 1998 Aug; 41(18):3515-29. PubMed ID: 9719605
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C; Spalluto G; Prato M; Adams M; Bodensieck A; Bauer R; Tubaro A; Bernardi P; Da Ros T
    Farmaco; 2005 Apr; 60(4):327-32. PubMed ID: 15848208
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
    Özadalı K; Özkanlı F; Jain S; Rao PP; Velázquez-Martínez CA
    Bioorg Med Chem; 2012 May; 20(9):2912-22. PubMed ID: 22475926
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
    Tan CM; Chen GS; Chen CS; Chang PT; Chern JW
    Bioorg Med Chem; 2011 Nov; 19(21):6316-28. PubMed ID: 21958737
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Binding investigation of human 5-lipoxygenase with its inhibitors by SPR technology correlating with molecular docking simulation.
    Du L; Zhang Z; Luo X; Chen K; Shen X; Jiang H
    J Biochem; 2006 Apr; 139(4):715-23. PubMed ID: 16672272
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.
    Chen CS; Tan CM; Huang CH; Chang LC; Wang JP; Cheng FC; Chern JW
    Bioorg Med Chem; 2010 Jan; 18(2):597-604. PubMed ID: 20056549
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Genome wide analysis and comparative docking studies of new diaryl furan derivatives against human cyclooxygenase-2, lipoxygenase, thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway.
    Sekhar PN; Reddy LA; De Maeyer M; Kumar KP; Srinivasulu YS; Sunitha MS; Sphoorthi IS; Jayasree G; Rao AM; Kothekar VS; Narayana PV; Kishor PB
    J Mol Graph Model; 2009 Nov; 28(4):313-29. PubMed ID: 19766029
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
    Reddy MV; Billa VK; Pallela VR; Mallireddigari MR; Boominathan R; Gabriel JL; Reddy EP
    Bioorg Med Chem; 2008 Apr; 16(7):3907-16. PubMed ID: 18272371
    [TBL] [Abstract][Full Text] [Related]  

  • 13. New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.
    Janusz JM; Young PA; Scherz MW; Enzweiler K; Wu LI; Gan L; Pikul S; McDow-Dunham KL; Johnson CR; Senanayake CB; Kellstein DE; Green SA; Tulich JL; Rosario-Jansen T; Magrisso IJ; Wehmeyer KR; Kuhlenbeck DL; Eichhold TH; Dobson RL
    J Med Chem; 1998 Mar; 41(7):1124-37. PubMed ID: 9544212
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Computer-aided discovery of anti-inflammatory thiazolidinones with dual cyclooxygenase/lipoxygenase inhibition.
    Geronikaki AA; Lagunin AA; Hadjipavlou-Litina DI; Eleftheriou PT; Filimonov DA; Poroikov VV; Alam I; Saxena AK
    J Med Chem; 2008 Mar; 51(6):1601-9. PubMed ID: 18311898
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
    Chen QH; Rao PN; Knaus EE
    Bioorg Med Chem; 2006 Dec; 14(23):7898-909. PubMed ID: 16904331
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Binding interaction analysis of the active site and its inhibitors for neuraminidase (N1 subtype) of human influenza virus by the integration of molecular docking, FMO calculation and 3D-QSAR CoMFA modeling.
    Zhang Q; Yang J; Liang K; Feng L; Li S; Wan J; Xu X; Yang G; Liu D; Yang S
    J Chem Inf Model; 2008 Sep; 48(9):1802-12. PubMed ID: 18707092
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 3D-QSAR and docking studies of aldehyde inhibitors of human cathepsin K.
    Pan X; Tan N; Zeng G; Han H; Huang H
    Bioorg Med Chem; 2006 Apr; 14(8):2771-8. PubMed ID: 16377193
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.
    Li Y; Chen SH; Ou TM; Tan JH; Li D; Gu LQ; Huang ZS
    Bioorg Med Chem; 2011 Mar; 19(6):2074-83. PubMed ID: 21349729
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular docking and 3D QSAR studies on 1-amino-2-phenyl-4-(piperidin-1-yl)-butanes based on the structural modeling of human CCR5 receptor.
    Xu Y; Liu H; Niu C; Luo C; Luo X; Shen J; Chen K; Jiang H
    Bioorg Med Chem; 2004 Dec; 12(23):6193-208. PubMed ID: 15519163
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase.
    Zuo Z; Luo X; Zhu W; Shen J; Shen X; Jiang H; Chen K
    Bioorg Med Chem; 2005 Mar; 13(6):2121-31. PubMed ID: 15727865
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 29.