BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

184 related articles for article (PubMed ID: 16458519)

  • 1. Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.
    Pautus S; Yee SW; Jayne M; Coogan MP; Simons C
    Bioorg Med Chem; 2006 Jun; 14(11):3643-53. PubMed ID: 16458519
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of substituted imidazole and triazole N-phenylbenzo[d]oxazolamine inhibitors of retinoic acid metabolizing enzyme CYP26.
    Pautus S; Aboraia AS; Bassett CE; Brancale A; Coogan MP; Simons C
    J Enzyme Inhib Med Chem; 2009 Apr; 24(2):487-98. PubMed ID: 18608743
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).
    Gomaa MS; Bridgens CE; Veal GJ; Redfern CP; Brancale A; Armstrong JL; Simons C
    J Med Chem; 2011 Oct; 54(19):6803-11. PubMed ID: 21838328
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells.
    Gomaa MS; Armstrong JL; Bobillon B; Veal GJ; Brancale A; Redfern CP; Simons C
    Bioorg Med Chem; 2008 Sep; 16(17):8301-13. PubMed ID: 18722776
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold.
    Gomaa MS; Bridgens CE; Illingworth NA; Veal GJ; Redfern CP; Brancale A; Armstrong JL; Simons C
    Bioorg Med Chem; 2012 Jul; 20(14):4201-7. PubMed ID: 22727372
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation.
    Saberi MR; Vinh TK; Yee SW; Griffiths BJ; Evans PJ; Simons C
    J Med Chem; 2006 Feb; 49(3):1016-22. PubMed ID: 16451067
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates.
    Gomaa MS; Lim AS; Lau SC; Watts AM; Illingworth NA; Bridgens CE; Veal GJ; Redfern CP; Brancale A; Armstrong JL; Simons C
    Bioorg Med Chem; 2012 Oct; 20(20):6080-8. PubMed ID: 22989911
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays.
    Yee SW; Jarno L; Gomaa MS; Elford C; Ooi LL; Coogan MP; McClelland R; Nicholson RI; Evans BA; Brancale A; Simons C
    J Med Chem; 2005 Nov; 48(23):7123-31. PubMed ID: 16279770
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates.
    Gomaa MS; Bridgens CE; Aboraia AS; Veal GJ; Redfern CP; Brancale A; Armstrong JL; Simons C
    J Med Chem; 2011 Apr; 54(8):2778-91. PubMed ID: 21428449
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase.
    Thatcher JE; Buttrick B; Shaffer SA; Shimshoni JA; Goodlett DR; Nelson WL; Isoherranen N
    Mol Pharmacol; 2011 Aug; 80(2):228-39. PubMed ID: 21521770
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors.
    Sun B; Liu K; Han J; Zhao LY; Su X; Lin B; Zhao DM; Cheng MS
    Bioorg Med Chem; 2015 Oct; 23(20):6763-73. PubMed ID: 26365710
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1).
    Zhao D; Sun B; Ren J; Li F; Song S; Lv X; Hao C; Cheng M
    Bioorg Med Chem; 2015 Mar; 23(6):1356-65. PubMed ID: 25684424
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding.
    Gomaa MS; Yee SW; Milbourne CE; Barbera MC; Simons C; Brancale A
    J Enzyme Inhib Med Chem; 2006 Aug; 21(4):361-9. PubMed ID: 17059167
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis, 3D-QSAR, and docking studies of 1-phenyl-1H-1,2,3-triazoles as selective antagonists for beta3 over alpha1beta2gamma2 GABA receptors.
    Alam MS; Huang J; Ozoe F; Matsumura F; Ozoe Y
    Bioorg Med Chem; 2007 Aug; 15(15):5090-104. PubMed ID: 17544280
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Molecular recognition of CYP26A1 binding pockets and structure-activity relationship studies for design of potent and selective retinoic acid metabolism blocking agents.
    Sun B; Song S; Hao CZ; Huang WX; Liu CC; Xie HL; Lin B; Cheng MS; Zhao DM
    J Mol Graph Model; 2015 Mar; 56():10-9. PubMed ID: 25541526
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Retinoic acid metabolism inhibition by 3-azolylmethyl-1H-indoles and 2, 3 or 5-(alpha-azolylbenzyl)-1H-indoles.
    Le Borgne M; Marchand P; Le Baut G; Ahmadi M; Smith HJ; Nicholls PJ
    J Enzyme Inhib Med Chem; 2003 Apr; 18(2):155-8. PubMed ID: 12943199
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 1-[(Benzofuran-2-yl)phenylmethyl]triazoles as steroidogenic inhibitors: synthesis and in vitro inhibition of human placental CYP19 aromatase.
    Vinh TK; Yee SW; Kirby AJ; Nicholls PJ; Simons C
    Anticancer Drug Des; 2001; 16(4-5):217-25. PubMed ID: 12049480
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids.
    Liang Z; Xu H; Tian Y; Guo M; Su X; Guo C
    Molecules; 2016 Jun; 21(6):. PubMed ID: 27338311
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum.
    Cao X; Hu M; Zhang J; Li F; Yang Y; Liu D; Liu SH
    J Agric Food Chem; 2009 Aug; 57(15):6914-9. PubMed ID: 19572650
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rational design and synthesis of novel dibenzo[b,d]furan-1,2,3-triazole conjugates as potent inhibitors of Mycobacterium tuberculosis.
    Yempala T; Sridevi JP; Yogeeswari P; Sriram D; Kantevari S
    Eur J Med Chem; 2014 Jan; 71():160-7. PubMed ID: 24292337
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.