BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 16475929)

  • 1. Towards species-specific antifolates.
    Chan DC; Anderson AC
    Curr Med Chem; 2006; 13(4):377-98. PubMed ID: 16475929
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii.
    Bartlett MS; Shaw M; Navaran P; Smith JW; Queener SF
    Antimicrob Agents Chemother; 1995 Nov; 39(11):2436-41. PubMed ID: 8585722
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.
    Allegra CJ; Kovacs JA; Drake JC; Swan JC; Chabner BA; Masur H
    J Exp Med; 1987 Mar; 165(3):926-31. PubMed ID: 2950200
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.
    Rosowsky A; Forsch RA; Queener SF
    J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
    Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A
    J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
    Piper JR; Johnson CA; Krauth CA; Carter RL; Hosmer CA; Queener SF; Borotz SE; Pfefferkorn ER
    J Med Chem; 1996 Mar; 39(6):1271-80. PubMed ID: 8632434
    [TBL] [Abstract][Full Text] [Related]  

  • 7. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
    Rosowsky A; Forsch RA; Sibley CH; Inderlied CB; Queener SF
    J Med Chem; 2004 Mar; 47(6):1475-86. PubMed ID: 14998335
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.
    Cody V; Pace J; Namjoshi OA; Gangjee A
    Acta Crystallogr F Struct Biol Commun; 2015 Jun; 71(Pt 6):799-803. PubMed ID: 26057816
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
    Shah K; Lin X; Queener SF; Cody V; Pace J; Gangjee A
    Bioorg Med Chem; 2018 May; 26(9):2640-2650. PubMed ID: 29691153
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast.
    Cortese JF; Plowe CV
    Mol Biochem Parasitol; 1998 Aug; 94(2):205-14. PubMed ID: 9747971
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
    Assaraf YG; Slotky JI
    J Biol Chem; 1993 Feb; 268(6):4556-66. PubMed ID: 8440739
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling.
    Aroonsri A; Akinola O; Posayapisit N; Songsungthong W; Uthaipibull C; Kamchonwongpaisan S; Gbotosho GO; Yuthavong Y; Shaw PJ
    Int J Parasitol; 2016 Jul; 46(8):527-35. PubMed ID: 27150044
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
    Rosowsky A; Forsch RA; Queener SF
    J Med Chem; 2003 Apr; 46(9):1726-36. PubMed ID: 12699390
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human malaria parasite Plasmodium falciparum.
    Chen GX; Mueller C; Wendlinger M; Zolg JW
    Mol Pharmacol; 1987 Apr; 31(4):430-7. PubMed ID: 3553892
    [TBL] [Abstract][Full Text] [Related]  

  • 15. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.
    Cody V; Pace J; Chisum K; Rosowsky A
    Proteins; 2006 Dec; 65(4):959-69. PubMed ID: 17019704
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase.
    Ma L; Kovacs JA
    Antimicrob Agents Chemother; 2000 Nov; 44(11):3092-6. PubMed ID: 11036028
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.
    Cody V; Pace J; Makin J; Piraino J; Queener SF; Rosowsky A
    Biochemistry; 2009 Mar; 48(8):1702-11. PubMed ID: 19196009
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.
    Forsch RA; Queener SF; Rosowsky A
    Bioorg Med Chem Lett; 2004 Apr; 14(7):1811-5. PubMed ID: 15026078
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of Pneumocystis dihydrofolate reductase by analogs of pyrimethamine, methotrexate and trimetrexate.
    Queener SF
    J Protozool; 1991; 38(6):154S-157S. PubMed ID: 1840146
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Recombinant Plasmodium falciparum dihydrofolate reductase-based in vitro screen for antifolate antimalarials.
    Brobey RK; Sano G; Itoh F; Aso K; Kimura M; Mitamura T; Horii T
    Mol Biochem Parasitol; 1996 Oct; 81(2):225-37. PubMed ID: 8898337
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.