BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

242 related articles for article (PubMed ID: 16476778)

  • 1. Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.
    Pal A; Severin F; Lommer B; Shevchenko A; Zerial M
    J Cell Biol; 2006 Feb; 172(4):605-18. PubMed ID: 16476778
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regulation of endosome dynamics by Rab5 and Huntingtin-HAP40 effector complex in physiological versus pathological conditions.
    Pal A; Severin F; Höpfner S; Zerial M
    Methods Enzymol; 2008; 438():239-57. PubMed ID: 18413253
    [TBL] [Abstract][Full Text] [Related]  

  • 3. HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis.
    Xu S; Li G; Ye X; Chen D; Chen Z; Xu Z; Daniele M; Tambone S; Ceccacci A; Tomei L; Ye L; Yu Y; Solbach A; Farmer SM; Stimming EF; McAllister G; Marchionini DM; Zhang S
    PLoS Genet; 2022 Jul; 18(7):e1010302. PubMed ID: 35853002
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.
    Ravikumar B; Imarisio S; Sarkar S; O'Kane CJ; Rubinsztein DC
    J Cell Sci; 2008 May; 121(Pt 10):1649-60. PubMed ID: 18430781
    [TBL] [Abstract][Full Text] [Related]  

  • 5. HAP40 protein levels are huntingtin-dependent and decrease in Huntington disease.
    Huang B; Seefelder M; Buck E; Engler T; Lindenberg KS; Klein F; Landwehrmeyer GB; Kochanek S
    Neurobiol Dis; 2021 Oct; 158():105476. PubMed ID: 34390835
    [TBL] [Abstract][Full Text] [Related]  

  • 6. HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice.
    Chen L; Qin Y; Guo T; Zhu W; Lin J; Xing T; Duan X; Zhang Y; Ruan E; Li X; Yin P; Li S; Li XJ; Yang S
    Cell Death Dis; 2024 May; 15(5):337. PubMed ID: 38744826
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.
    Huang B; Guo Q; Niedermeier ML; Cheng J; Engler T; Maurer M; Pautsch A; Baumeister W; Stengel F; Kochanek S; Fernández-Busnadiego R
    Structure; 2021 Aug; 29(8):804-809.e5. PubMed ID: 33909994
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.
    Nielsen E; Christoforidis S; Uttenweiler-Joseph S; Miaczynska M; Dewitte F; Wilm M; Hoflack B; Zerial M
    J Cell Biol; 2000 Oct; 151(3):601-12. PubMed ID: 11062261
    [TBL] [Abstract][Full Text] [Related]  

  • 9. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.
    Kajiho H; Saito K; Tsujita K; Kontani K; Araki Y; Kurosu H; Katada T
    J Cell Sci; 2003 Oct; 116(Pt 20):4159-68. PubMed ID: 12972505
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of p38 Mitogen-Activated Protein Kinase Ameliorates HAP40 Depletion-Induced Toxicity and Proteasomal Defect in Huntington's Disease Model.
    Huang ZN; Chen JM; Huang LC; Fang YH; Her LS
    Mol Neurobiol; 2021 Jun; 58(6):2704-2723. PubMed ID: 33492644
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects.
    Huang ZN; Chung HM; Fang SC; Her LS
    Int J Biol Sci; 2017; 13(11):1420-1437. PubMed ID: 29209146
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease.
    Seefelder M; Klein FAC; Landwehrmeyer B; Fernández-Busnadiego R; Kochanek S
    J Huntingtons Dis; 2022; 11(3):227-242. PubMed ID: 35871360
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Rab5 regulates motility of early endosomes on microtubules.
    Nielsen E; Severin F; Backer JM; Hyman AA; Zerial M
    Nat Cell Biol; 1999 Oct; 1(6):376-82. PubMed ID: 10559966
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.
    Huang ZN; Her LS
    Mol Neurobiol; 2017 Nov; 54(9):7382-7400. PubMed ID: 27815841
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.
    Kim S; Sato Y; Mohan PS; Peterhoff C; Pensalfini A; Rigoglioso A; Jiang Y; Nixon RA
    Mol Psychiatry; 2016 May; 21(5):707-16. PubMed ID: 26194181
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Effectors of GTPase Rab5 in endocytosis and signal transduction].
    Olchowik M; Miaczyńska M
    Postepy Biochem; 2009; 55(2):171-80. PubMed ID: 19824473
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin.
    Seefelder M; Alva V; Huang B; Engler T; Baumeister W; Guo Q; Fernández-Busnadiego R; Lupas AN; Kochanek S
    BMC Evol Biol; 2020 Dec; 20(1):162. PubMed ID: 33297953
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Isolation of a 40-kDa Huntingtin-associated protein.
    Peters MF; Ross CA
    J Biol Chem; 2001 Feb; 276(5):3188-94. PubMed ID: 11035034
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.
    Li X; Standley C; Sapp E; Valencia A; Qin ZH; Kegel KB; Yoder J; Comer-Tierney LA; Esteves M; Chase K; Alexander J; Masso N; Sobin L; Bellve K; Tuft R; Lifshitz L; Fogarty K; Aronin N; DiFiglia M
    Mol Cell Biol; 2009 Nov; 29(22):6106-16. PubMed ID: 19752198
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.
    Harding RJ; Deme JC; Hevler JF; Tamara S; Lemak A; Cantle JP; Szewczyk MM; Begeja N; Goss S; Zuo X; Loppnau P; Seitova A; Hutchinson A; Fan L; Truant R; Schapira M; Carroll JB; Heck AJR; Lea SM; Arrowsmith CH
    Commun Biol; 2021 Dec; 4(1):1374. PubMed ID: 34880419
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.