133 related articles for article (PubMed ID: 16480864)
1. 4-Amino derivatives of the Hsp90 inhibitor CCT018159.
Barril X; Beswick MC; Collier A; Drysdale MJ; Dymock BW; Fink A; Grant K; Howes R; Jordan AM; Massey A; Surgenor A; Wayne J; Workman P; Wright L
Bioorg Med Chem Lett; 2006 May; 16(9):2543-8. PubMed ID: 16480864
[TBL] [Abstract][Full Text] [Related]
2. The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
Cheung KM; Matthews TP; James K; Rowlands MG; Boxall KJ; Sharp SY; Maloney A; Roe SM; Prodromou C; Pearl LH; Aherne GW; McDonald E; Workman P
Bioorg Med Chem Lett; 2005 Jul; 15(14):3338-43. PubMed ID: 15955698
[TBL] [Abstract][Full Text] [Related]
3. In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.
Sharp SY; Boxall K; Rowlands M; Prodromou C; Roe SM; Maloney A; Powers M; Clarke PA; Box G; Sanderson S; Patterson L; Matthews TP; Cheung KM; Ball K; Hayes A; Raynaud F; Marais R; Pearl L; Eccles S; Aherne W; McDonald E; Workman P
Cancer Res; 2007 Mar; 67(5):2206-16. PubMed ID: 17332351
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Sharp SY; Prodromou C; Boxall K; Powers MV; Holmes JL; Box G; Matthews TP; Cheung KM; Kalusa A; James K; Hayes A; Hardcastle A; Dymock B; Brough PA; Barril X; Cansfield JE; Wright L; Surgenor A; Foloppe N; Hubbard RE; Aherne W; Pearl L; Jones K; McDonald E; Raynaud F; Eccles S; Drysdale M; Workman P
Mol Cancer Ther; 2007 Apr; 6(4):1198-211. PubMed ID: 17431102
[TBL] [Abstract][Full Text] [Related]
5. Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors.
Smith NF; Hayes A; James K; Nutley BP; McDonald E; Henley A; Dymock B; Drysdale MJ; Raynaud FI; Workman P
Mol Cancer Ther; 2006 Jun; 5(6):1628-37. PubMed ID: 16818523
[TBL] [Abstract][Full Text] [Related]
6. Discovery and development of pyrazole-scaffold Hsp90 inhibitors.
McDonald E; Jones K; Brough PA; Drysdale MJ; Workman P
Curr Top Med Chem; 2006; 6(11):1193-203. PubMed ID: 16842156
[TBL] [Abstract][Full Text] [Related]
7. [Progress in the study of heat shock protein 90 inhibitors].
Luo HM; Sun W; Yin JY; Yang XH
Yao Xue Xue Bao; 2010 Jul; 45(7):813-20. PubMed ID: 20931776
[TBL] [Abstract][Full Text] [Related]
8. Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.
Beloueche-Babari M; Arunan V; Jackson LE; Perusinghe N; Sharp SY; Workman P; Leach MO
Oncotarget; 2010 Jul; 1(3):185-97. PubMed ID: 21037799
[TBL] [Abstract][Full Text] [Related]
9. Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Kreusch A; Han S; Brinker A; Zhou V; Choi HS; He Y; Lesley SA; Caldwell J; Gu XJ
Bioorg Med Chem Lett; 2005 Mar; 15(5):1475-8. PubMed ID: 15713410
[TBL] [Abstract][Full Text] [Related]
10. 3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone.
Brough PA; Barril X; Beswick M; Dymock BW; Drysdale MJ; Wright L; Grant K; Massey A; Surgenor A; Workman P
Bioorg Med Chem Lett; 2005 Dec; 15(23):5197-201. PubMed ID: 16213716
[TBL] [Abstract][Full Text] [Related]
11. Discovery of novel HSP90 inhibitors that induced apoptosis and impaired autophagic flux in A549 lung cancer cells.
Wei Q; Ning JY; Dai X; Gao YD; Su L; Zhao BX; Miao JY
Eur J Med Chem; 2018 Feb; 145():551-558. PubMed ID: 29339250
[TBL] [Abstract][Full Text] [Related]
12. cis-6-oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-oxo-hexahydropyrrolo[3,2-c]pyrazole based scaffolds: design rationale, synthesis and cysteinyl proteinase inhibition.
Wang Y; Benn A; Flinn N; Monk T; Ramjee M; Watts J; Quibell M
Bioorg Med Chem Lett; 2005 Mar; 15(5):1327-31. PubMed ID: 15713380
[TBL] [Abstract][Full Text] [Related]
13. A fluorescence polarization assay for inhibitors of Hsp90.
Howes R; Barril X; Dymock BW; Grant K; Northfield CJ; Robertson AG; Surgenor A; Wayne J; Wright L; James K; Matthews T; Cheung KM; McDonald E; Workman P; Drysdale MJ
Anal Biochem; 2006 Mar; 350(2):202-13. PubMed ID: 16460658
[TBL] [Abstract][Full Text] [Related]
14. Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
Dymock BW; Barril X; Brough PA; Cansfield JE; Massey A; McDonald E; Hubbard RE; Surgenor A; Roughley SD; Webb P; Workman P; Wright L; Drysdale MJ
J Med Chem; 2005 Jun; 48(13):4212-5. PubMed ID: 15974572
[TBL] [Abstract][Full Text] [Related]
15. Discovery of 5-aryl-3-thiophen-2-yl-1H-pyrazoles as a new class of Hsp90 inhibitors in hepatocellular carcinoma.
Mohamady S; Ismail MI; Mogheith SM; Attia YM; Taylor SD
Bioorg Chem; 2020 Jan; 94():103433. PubMed ID: 31785857
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004.
Raeppel F; Raeppel SL; Therrien E
Bioorg Med Chem Lett; 2015 Sep; 25(18):3810-5. PubMed ID: 26243370
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and molecular docking studies of novel pyrazolyl 2-aminopyrimidine derivatives as HSP90 inhibitors.
Mettu A; Talla V; Bajaj DM; Subhashini NJP
Arch Pharm (Weinheim); 2019 Oct; 352(10):e1900063. PubMed ID: 31411362
[TBL] [Abstract][Full Text] [Related]
18. Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.
Hardcastle A; Boxall K; Richards J; Tomlin P; Sharp S; Clarke P; Workman P; Aherne W
Assay Drug Dev Technol; 2005 Jun; 3(3):273-85. PubMed ID: 15971989
[TBL] [Abstract][Full Text] [Related]
19. 5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone.
Cikotiene I; Kazlauskas E; Matuliene J; Michailoviene V; Torresan J; Jachno J; Matulis D
Bioorg Med Chem Lett; 2009 Feb; 19(4):1089-92. PubMed ID: 19168355
[TBL] [Abstract][Full Text] [Related]
20. Discovery of N-pyridoyl-Δ
Kadasi S; Yerroju R; Gaddam S; Pullanagiri N; Chary M; Pingili D; Raj S; Raghavendra NM
Arch Pharm (Weinheim); 2020 Feb; 353(2):e1900192. PubMed ID: 31808979
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]