BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

363 related articles for article (PubMed ID: 16488975)

  • 1. Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants.
    Khare SD; Dokholyan NV
    Proc Natl Acad Sci U S A; 2006 Feb; 103(9):3147-52. PubMed ID: 16488975
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: a computational study.
    Milardi D; Pappalardo M; Grasso DM; La Rosa C
    Mol Biosyst; 2010 Jun; 6(6):1032-9. PubMed ID: 20485746
    [TBL] [Abstract][Full Text] [Related]  

  • 3. FALS mutations in Cu, Zn superoxide dismutase destabilize the dimer and increase dimer dissociation propensity: a large-scale thermodynamic analysis.
    Khare SD; Caplow M; Dokholyan NV
    Amyloid; 2006 Dec; 13(4):226-35. PubMed ID: 17107883
    [TBL] [Abstract][Full Text] [Related]  

  • 4. An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis.
    Ray SS; Nowak RJ; Strokovich K; Brown RH; Walz T; Lansbury PT
    Biochemistry; 2004 May; 43(17):4899-905. PubMed ID: 15109247
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.
    Ray SS; Nowak RJ; Brown RH; Lansbury PT
    Proc Natl Acad Sci U S A; 2005 Mar; 102(10):3639-44. PubMed ID: 15738401
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis.
    Strange RW; Antonyuk S; Hough MA; Doucette PA; Rodriguez JA; Hart PJ; Hayward LJ; Valentine JS; Hasnain SS
    J Mol Biol; 2003 May; 328(4):877-91. PubMed ID: 12729761
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of three mutations in the Cu,Zn-superoxide dismutase (Cu,Zn-SOD) gene with familial amyotrophic lateral sclerosis: transduction of human Cu,Zn-SOD into PC12 cells by HIV-1 TAT protein basic domain.
    Chou CM; Huang CJ; Shih CM; Chen YP; Liu TP; Chen CT
    Ann N Y Acad Sci; 2005 May; 1042():303-13. PubMed ID: 15965076
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sequence and structural determinants of Cu, Zn superoxide dismutase aggregation.
    Khare SD; Wilcox KC; Gong P; Dokholyan NV
    Proteins; 2005 Nov; 61(3):617-32. PubMed ID: 16152647
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.
    Schmidlin T; Kennedy BK; Daggett V
    Biophys J; 2009 Sep; 97(6):1709-18. PubMed ID: 19751676
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis.
    Khare SD; Caplow M; Dokholyan NV
    Proc Natl Acad Sci U S A; 2004 Oct; 101(42):15094-9. PubMed ID: 15475574
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu-Zn superoxide dismutase.
    Strange RW; Yong CW; Smith W; Hasnain SS
    Proc Natl Acad Sci U S A; 2007 Jun; 104(24):10040-4. PubMed ID: 17548825
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metalation of the amyotrophic lateral sclerosis mutant glycine 37 to arginine superoxide dismutase (SOD1) apoprotein restores its structural and dynamical properties in solution to those of metalated wild-type SOD1.
    Banci L; Bertini I; D'Amelio N; Libralesso E; Turano P; Valentine JS
    Biochemistry; 2007 Sep; 46(35):9953-62. PubMed ID: 17683122
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural discovery of small molecule binding sites in Cu-Zn human superoxide dismutase familial amyotrophic lateral sclerosis mutants provides insights for lead optimization.
    Antonyuk S; Strange RW; Hasnain SS
    J Med Chem; 2010 Feb; 53(3):1402-6. PubMed ID: 20067275
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis.
    Mulligan VK; Kerman A; Ho S; Chakrabartty A
    J Mol Biol; 2008 Nov; 383(2):424-36. PubMed ID: 18761352
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Proteasome inhibition enhances the stability of mouse Cu/Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis.
    Hoffman EK; Wilcox HM; Scott RW; Siman R
    J Neurol Sci; 1996 Jul; 139(1):15-20. PubMed ID: 8836967
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amyotrophic lateral sclerosis disease-related mutations disrupt the dimerization of superoxide dismutase 1 - A comparative molecular dynamics simulation study.
    Basith S; Manavalan B; Lee G
    Comput Biol Med; 2022 Dec; 151(Pt B):106319. PubMed ID: 36446187
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.
    Antonyuk S; Elam JS; Hough MA; Strange RW; Doucette PA; Rodriguez JA; Hayward LJ; Valentine JS; Hart PJ; Hasnain SS
    Protein Sci; 2005 May; 14(5):1201-13. PubMed ID: 15840828
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Reduced net charge and heterogeneity of pI isoforms in familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase.
    Roudeau S; Chevreux S; Carmona A; Ortega R
    Electrophoresis; 2015 Oct; 36(19):2482-8. PubMed ID: 26084641
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparative structural and conformational studies on H43R and W32F mutants of copper-zinc superoxide dismutase by molecular dynamics simulation.
    Muneeswaran G; Kartheeswaran S; Muthukumar K; Dharmaraj CD; Karunakaran C
    Biophys Chem; 2014 Jan; 185():70-8. PubMed ID: 24369116
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis.
    Furukawa Y; Kaneko K; Yamanaka K; Nukina N
    J Biol Chem; 2010 Jul; 285(29):22221-31. PubMed ID: 20404329
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.