177 related articles for article (PubMed ID: 16507648)
1. Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients.
Goda R; Nagai D; Akiyama Y; Nishikawa K; Ikemoto I; Aizawa Y; Nagata K; Yamazoe Y
Drug Metab Dispos; 2006 May; 34(5):828-35. PubMed ID: 16507648
[TBL] [Abstract][Full Text] [Related]
2. Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.
Tevell A; Lennernäs H; Jönsson M; Norlin M; Lennernäs B; Bondesson U; Hedeland M
Drug Metab Dispos; 2006 Jun; 34(6):984-92. PubMed ID: 16540588
[TBL] [Abstract][Full Text] [Related]
3. Bioactivation of flutamide metabolites by human liver microsomes.
Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
[TBL] [Abstract][Full Text] [Related]
4. Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity.
Ohbuchi M; Miyata M; Nagai D; Shimada M; Yoshinari K; Yamazoe Y
Drug Metab Dispos; 2009 Jan; 37(1):97-105. PubMed ID: 18832480
[TBL] [Abstract][Full Text] [Related]
5. [Sex-difference on flutamide metabolism in rat liver microsomal cytochrome P450 1A2].
Wang HX; Li D; Xu CJ; Liu X
Yao Xue Xue Bao; 2002 Aug; 37(8):608-10. PubMed ID: 12567773
[TBL] [Abstract][Full Text] [Related]
6. Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
Kostrubsky SE; Strom SC; Ellis E; Nelson SD; Mutlib AE
Chem Res Toxicol; 2007 Oct; 20(10):1503-12. PubMed ID: 17900172
[TBL] [Abstract][Full Text] [Related]
7. Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2.
Shet MS; McPhaul M; Fisher CW; Stallings NR; Estabrook RW
Drug Metab Dispos; 1997 Nov; 25(11):1298-303. PubMed ID: 9351907
[TBL] [Abstract][Full Text] [Related]
8. Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies.
Berson A; Wolf C; Chachaty C; Fisch C; Fau D; Eugene D; Loeper J; Gauthier JC; Beaune P; Pompon D
J Pharmacol Exp Ther; 1993 Apr; 265(1):366-72. PubMed ID: 8386241
[TBL] [Abstract][Full Text] [Related]
9. Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice.
Matsuzaki Y; Nagai D; Ichimura E; Goda R; Tomura A; Doi M; Nishikawa K
J Gastroenterol; 2006 Mar; 41(3):231-9. PubMed ID: 16699857
[TBL] [Abstract][Full Text] [Related]
10. 3-ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acid.
Deo AK; Bandiera SM
Drug Metab Dispos; 2009 Sep; 37(9):1938-47. PubMed ID: 19487251
[TBL] [Abstract][Full Text] [Related]
11. Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.
Kang P; Dalvie D; Smith E; Zhou S; Deese A
Drug Metab Dispos; 2007 Jul; 35(7):1081-8. PubMed ID: 17403914
[TBL] [Abstract][Full Text] [Related]
12. Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride.
Teichert J; Baumann F; Chao Q; Franklin C; Bailey B; Hennig L; Caca K; Schoppmeyer K; Patzak U; Preiss R
Cancer Chemother Pharmacol; 2007 May; 59(6):759-70. PubMed ID: 16957931
[TBL] [Abstract][Full Text] [Related]
13. Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
Altuntas TG; Park SB; Kharasch ED
Chem Res Toxicol; 2004 Mar; 17(3):435-45. PubMed ID: 15025515
[TBL] [Abstract][Full Text] [Related]
14. Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase.
Wen B; Coe KJ; Rademacher P; Fitch WL; Monshouwer M; Nelson SD
Chem Res Toxicol; 2008 Dec; 21(12):2393-406. PubMed ID: 19548358
[TBL] [Abstract][Full Text] [Related]
15. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
Wen B; Ma L; Zhu M
Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
[TBL] [Abstract][Full Text] [Related]
16. CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.
Prakash C; Wang W; O'Connell T; Johnson KA
Drug Metab Dispos; 2008 Oct; 36(10):2093-103. PubMed ID: 18653741
[TBL] [Abstract][Full Text] [Related]
17. Salutary clinical response of prostate cancer to antiandrogen withdrawal: assessment of flutamide in an in vitro paradigm predictive of tumor growth enhancement.
Brandes LJ; Queen GM; LaBella FS
Clin Cancer Res; 1997 Aug; 3(8):1357-61. PubMed ID: 9815819
[TBL] [Abstract][Full Text] [Related]
18. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
[TBL] [Abstract][Full Text] [Related]
19. Contributions of arylacetamide deacetylase and carboxylesterase 2 to flutamide hydrolysis in human liver.
Kobayashi Y; Fukami T; Shimizu M; Nakajima M; Yokoi T
Drug Metab Dispos; 2012 Jun; 40(6):1080-4. PubMed ID: 22446520
[TBL] [Abstract][Full Text] [Related]
20. Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism.
Winter HR; Unadkat JD
Drug Metab Dispos; 2005 Jul; 33(7):969-76. PubMed ID: 15843491
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]