461 related articles for article (PubMed ID: 16509576)
1. Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.
Song YL; Peach ML; Roller PP; Qiu S; Wang S; Long YQ
J Med Chem; 2006 Mar; 49(5):1585-96. PubMed ID: 16509576
[TBL] [Abstract][Full Text] [Related]
2. Utilization of 3'-carboxy-containing tyrosine derivatives as a new class of phosphotyrosyl mimetics in the preparation of novel non-phosphorylated cyclic peptide inhibitors of the Grb2-SH2 domain.
Song YL; Tan J; Luo XM; Long YQ
Org Biomol Chem; 2006 Feb; 4(4):659-66. PubMed ID: 16467940
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine.
Long YQ; Xue T; Song YL; Liu ZL; Huang SX; Yu Q
J Med Chem; 2008 Oct; 51(20):6371-80. PubMed ID: 18821748
[TBL] [Abstract][Full Text] [Related]
4. Development of l-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity.
Song YL; Roller PP; Long YQ
Bioorg Med Chem Lett; 2004 Jun; 14(12):3205-8. PubMed ID: 15149676
[TBL] [Abstract][Full Text] [Related]
5. Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems.
Wei CQ; Gao Y; Lee K; Guo R; Li B; Zhang M; Yang D; Burke TR
J Med Chem; 2003 Jan; 46(2):244-54. PubMed ID: 12519063
[TBL] [Abstract][Full Text] [Related]
6. Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs.
Liu WQ; Vidal M; Olszowy C; Million E; Lenoir C; DhĂ´tel H; Garbay C
J Med Chem; 2004 Feb; 47(5):1223-33. PubMed ID: 14971902
[TBL] [Abstract][Full Text] [Related]
7. Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands.
Yao ZJ; King CR; Cao T; Kelley J; Milne GW; Voigt JH; Burke TR
J Med Chem; 1999 Jan; 42(1):25-35. PubMed ID: 9888830
[TBL] [Abstract][Full Text] [Related]
8. Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity.
Li P; Zhang M; Peach ML; Zhang X; Liu H; Nicklaus M; Yang D; Roller PP
Biochem Biophys Res Commun; 2003 Aug; 307(4):1038-44. PubMed ID: 12878216
[TBL] [Abstract][Full Text] [Related]
9. Structural requirements for Tyr in the consensus sequence Y-E-N of a novel nonphosphorylated inhibitor to the Grb2-SH2 domain.
Long YQ; Yao ZJ; Voigt JH; Lung FD; Luo JH; Burke TR; King CR; Yang D; Roller PP
Biochem Biophys Res Commun; 1999 Nov; 264(3):902-8. PubMed ID: 10544028
[TBL] [Abstract][Full Text] [Related]
10. Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain.
Lung FD; Long YQ; Roller PP; King CR; Varady J; Wu XW; Wang S
J Pept Res; 2001 Jun; 57(6):447-54. PubMed ID: 11437948
[TBL] [Abstract][Full Text] [Related]
11. L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides.
Ye B; Akamatsu M; Shoelson SE; Wolf G; Giorgetti-Peraldi S; Yan X; Roller PP; Burke TR
J Med Chem; 1995 Oct; 38(21):4270-5. PubMed ID: 7473554
[TBL] [Abstract][Full Text] [Related]
12. N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding.
Burke TR; Yao ZJ; Gao Y; Wu JX; Zhu X; Luo JH; Guo R; Yang D
Bioorg Med Chem; 2001 Jun; 9(6):1439-45. PubMed ID: 11408162
[TBL] [Abstract][Full Text] [Related]
13. Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.
Oishi S; Karki RG; Kang SU; Wang X; Worthy KM; Bindu LK; Nicklaus MC; Fisher RJ; Burke TR
J Med Chem; 2005 Feb; 48(3):764-72. PubMed ID: 15689160
[TBL] [Abstract][Full Text] [Related]
14. Utilization of a beta-aminophosphotyrosyl mimetic in the design and synthesis of macrocyclic Grb2 SH2 domain-binding peptides.
Lee K; Zhang M; Liu H; Yang D; Burke TR
J Med Chem; 2003 Jun; 46(13):2621-30. PubMed ID: 12801226
[TBL] [Abstract][Full Text] [Related]
15. Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.
Jiang S; Li P; Peach ML; Bindu L; Worthy KW; Fisher RJ; Burke TR; Nicklaus M; Roller PP
Biochem Biophys Res Commun; 2006 Oct; 349(2):497-503. PubMed ID: 16945340
[TBL] [Abstract][Full Text] [Related]
16. Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.
Long YQ; Guo R; Luo JH; Yang D; Roller PP
Biochem Biophys Res Commun; 2003 Oct; 310(2):334-40. PubMed ID: 14521914
[TBL] [Abstract][Full Text] [Related]
17. Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology.
Lung FD; Chang CW; Chong MC; Liou CC; Li P; Peach ML; Nicklaus MC; Lou BS; Roller PP
Biopolymers; 2005; 80(5):628-35. PubMed ID: 15660381
[TBL] [Abstract][Full Text] [Related]
18. Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
Nioche P; Liu WQ; Broutin I; Charbonnier F; Latreille MT; Vidal M; Roques B; Garbay C; Ducruix A
J Mol Biol; 2002 Feb; 315(5):1167-77. PubMed ID: 11827484
[TBL] [Abstract][Full Text] [Related]
19. Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity.
Jiang S; Liao C; Bindu L; Yin B; Worthy KW; Fisher RJ; Burke TR; Nicklaus MC; Roller PP
Bioorg Med Chem Lett; 2009 May; 19(10):2693-8. PubMed ID: 19362470
[TBL] [Abstract][Full Text] [Related]
20. Global optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.
Long YQ; Lung FD; Roller PP
Bioorg Med Chem; 2003 Sep; 11(18):3929-36. PubMed ID: 12927853
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]