236 related articles for article (PubMed ID: 16509591)
1. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.
Greiner E; Boos TL; Prisinzano TE; De Martino MG; Zeglis B; Dersch CM; Marcus J; Partilla JS; Rothman RB; Jacobson AE; Rice KC
J Med Chem; 2006 Mar; 49(5):1766-72. PubMed ID: 16509591
[TBL] [Abstract][Full Text] [Related]
2. Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors.
He R; Kurome T; Giberson KM; Johnson KM; Kozikowski AP
J Med Chem; 2005 Dec; 48(25):7970-9. PubMed ID: 16335921
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.
Gong PK; Blough BE; Brieaddy LE; Huang X; Kuhar MJ; Navarro HA; Carroll FI
J Med Chem; 2007 Jul; 50(15):3686-95. PubMed ID: 17602602
[TBL] [Abstract][Full Text] [Related]
4. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.
Greiner E; Prisinzano T; Johnson EM; Dersch CM; Marcus J; Partilla JS; Rothman RB; Jacobson AE; Rice KC
J Med Chem; 2003 Apr; 46(8):1465-9. PubMed ID: 12672246
[TBL] [Abstract][Full Text] [Related]
5. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
Orjales A; Mosquera R; Toledo A; Pumar MC; García N; Cortizo L; Labeaga L; Innerárity A
J Med Chem; 2003 Dec; 46(25):5512-32. PubMed ID: 14640559
[TBL] [Abstract][Full Text] [Related]
6. 1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors.
Micheli F; Cavanni P; Bettati M; Bonanomi G; Di Fabio R; Fazzolari E; Marchioro C; Roscic M; Tarsi L; Visentini F; Zonzini L; Worby A
Bioorg Med Chem; 2011 Jun; 19(11):3451-61. PubMed ID: 21550808
[TBL] [Abstract][Full Text] [Related]
7. Further SAR studies of piperidine-based analogues of cocaine. 2. Potent dopamine and serotonin reuptake inhibitors.
Tamiz AP; Zhang J; Flippen-Anderson JL; Zhang M; Johnson KM; Deschaux O; Tella S; Kozikowski AP
J Med Chem; 2000 Mar; 43(6):1215-22. PubMed ID: 10737754
[TBL] [Abstract][Full Text] [Related]
8. 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.
Meltzer PC; Butler D; Deschamps JR; Madras BK
J Med Chem; 2006 Feb; 49(4):1420-32. PubMed ID: 16480278
[TBL] [Abstract][Full Text] [Related]
9. Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters.
Hsin LW; Chang LT; Rothman RB; Dersch CM; Jacobson AE; Rice KC
J Med Chem; 2008 May; 51(9):2795-806. PubMed ID: 18393401
[TBL] [Abstract][Full Text] [Related]
10. Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors.
Zhang A; Zhou G; Hoepping A; Mukhopadhyaya J; Johnson KM; Zhang M; Kozikowski AP
J Med Chem; 2002 Apr; 45(9):1930-41. PubMed ID: 11960503
[TBL] [Abstract][Full Text] [Related]
11. Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter.
Boos TL; Greiner E; Calhoun WJ; Prisinzano TE; Nightingale B; Dersch CM; Rothman RB; Jacobson AE; Rice KC
Bioorg Med Chem; 2006 Jun; 14(11):3967-73. PubMed ID: 16563775
[TBL] [Abstract][Full Text] [Related]
12. Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.
Dutta AK; Xu C; Reith ME
J Med Chem; 1998 Aug; 41(17):3293-7. PubMed ID: 9703474
[TBL] [Abstract][Full Text] [Related]
13. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.
Kolhatkar RB; Ghorai SK; George C; Reith ME; Dutta AK
J Med Chem; 2003 May; 46(11):2205-15. PubMed ID: 12747792
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).
Zhang Y; Rothman RB; Dersch CM; de Costa BR; Jacobson AE; Rice KC
J Med Chem; 2000 Dec; 43(25):4840-9. PubMed ID: 11123994
[TBL] [Abstract][Full Text] [Related]
15. Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.
Dutta AK; Fei XS; Beardsley PM; Newman JL; Reith ME
J Med Chem; 2001 Mar; 44(6):937-48. PubMed ID: 11300876
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.
Park JE; Song C; Choi K; Sim T; Moon B; Roh EJ
Bioorg Med Chem Lett; 2013 Oct; 23(20):5515-8. PubMed ID: 24012181
[TBL] [Abstract][Full Text] [Related]
17. Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.
Banister SD; Moussa IA; Beinat C; Reynolds AJ; Schiavini P; Jorgensen WT; Kassiou M
Bioorg Med Chem Lett; 2011 Jan; 21(1):38-41. PubMed ID: 21146989
[TBL] [Abstract][Full Text] [Related]
18. Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter.
Prisinzano T; Greiner E; Johnson EM; Dersch CM; Marcus J; Partilla JS; Rothman RB; Jacobson AE; Rice KC
J Med Chem; 2002 Sep; 45(19):4371-4. PubMed ID: 12213078
[TBL] [Abstract][Full Text] [Related]
19. Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors.
Nencetti S; Mazzoni MR; Ortore G; Lapucci A; Giuntini J; Orlandini E; Banti I; Nuti E; Lucacchini A; Giannaccini G; Rossello A
Eur J Med Chem; 2011 Mar; 46(3):825-34. PubMed ID: 21272963
[TBL] [Abstract][Full Text] [Related]
20. The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.
Purushotham M; Sheri A; Pham-Huu DP; Madras BK; Janowsky A; Meltzer PC
Bioorg Med Chem Lett; 2011 Jan; 21(1):48-51. PubMed ID: 21146984
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]