These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 16510290)

  • 1. Design, synthesis, and evaluation of Leu*Ala hydroxyethylene-based non-peptide beta-secretase (BACE) inhibitors.
    Xiao K; Li X; Li J; Ma L; Hu B; Yu H; Fu Y; Wang R; Ma Z; Qiu B; Li J; Hu D; Wang X; Shen J
    Bioorg Med Chem; 2006 Jul; 14(13):4535-51. PubMed ID: 16510290
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.
    Hom RK; Gailunas AF; Mamo S; Fang LY; Tung JS; Walker DE; Davis D; Thorsett ED; Jewett NE; Moon JB; John V
    J Med Chem; 2004 Jan; 47(1):158-64. PubMed ID: 14695829
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
    Yang W; Lu W; Lu Y; Zhong M; Sun J; Thomas AE; Wilkinson JM; Fucini RV; Lam M; Randal M; Shi XP; Jacobs JW; McDowell RS; Gordon EM; Ballinger MD
    J Med Chem; 2006 Feb; 49(3):839-42. PubMed ID: 16451048
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modeling the binding affinities of beta-secretase inhibitors: application to subsite specificity.
    Rajamani R; Reynolds CH
    Bioorg Med Chem Lett; 2004 Oct; 14(19):4843-6. PubMed ID: 15341936
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
    Machauer R; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Neumann U; Paganetti P
    Bioorg Med Chem Lett; 2009 Mar; 19(5):1361-5. PubMed ID: 19195886
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human beta-secretase.
    Niu Y; Wang Y; Zou X; Yang X; Ma C; Lü Y; Zhou B; Yuan Y; Du G; Xu P
    Eur J Med Chem; 2010 May; 45(5):2089-94. PubMed ID: 20153560
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
    Lindsley SR; Moore KP; Rajapakse HA; Selnick HG; Young MB; Zhu H; Munshi S; Kuo L; McGaughey GB; Colussi D; Crouthamel MC; Lai MT; Pietrak B; Price EA; Sankaranarayanan S; Simon AJ; Seabrook GR; Hazuda DJ; Pudvah NT; Hochman JH; Graham SL; Vacca JP; Nantermet PG
    Bioorg Med Chem Lett; 2007 Jul; 17(14):4057-61. PubMed ID: 17482814
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.
    Garino C; Tomita T; Pietrancosta N; Laras Y; Rosas R; Herbette G; Maigret B; Quéléver G; Iwatsubo T; Kraus JL
    J Med Chem; 2006 Jul; 49(14):4275-85. PubMed ID: 16821787
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
    Bäck M; Nyhlén J; Kvarnström I; Appelgren S; Borkakoti N; Jansson K; Lindberg J; Nyström S; Hallberg A; Rosenquist S; Samuelsson B
    Bioorg Med Chem; 2008 Nov; 16(21):9471-86. PubMed ID: 18842420
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core.
    Wångsell F; Gustafsson K; Kvarnström I; Borkakoti N; Edlund M; Jansson K; Lindberg J; Hallberg A; Rosenquist A; Samuelsson B
    Eur J Med Chem; 2010 Mar; 45(3):870-82. PubMed ID: 20036448
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Preorganization of the hydroxyethylene dipeptide isostere: the preferred conformation in solution resembles the conformation bound to BACE.
    Vidal P; Timm D; Broughton H; Chen SH; Martín JA; Rivera-Sagredo A; McCarthy JR; Shapiro MJ; Espinosa JF
    J Med Chem; 2005 Dec; 48(24):7623-7. PubMed ID: 16302802
    [TBL] [Abstract][Full Text] [Related]  

  • 12. P2'-truncated BACE-1 inhibitors with a novel hydroxethylene-like core.
    Meredith JA; Björklund C; Adolfsson H; Jansson K; Hallberg A; Rosenquist A; Samuelsson B
    Eur J Med Chem; 2010 Feb; 45(2):542-54. PubMed ID: 19995674
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design and synthesis of potent and selective BACE-1 inhibitors.
    Björklund C; Oscarson S; Benkestock K; Borkakoti N; Jansson K; Lindberg J; Vrang L; Hallberg A; Rosenquist A; Samuelsson B
    J Med Chem; 2010 Feb; 53(4):1458-64. PubMed ID: 20128595
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hydroxytriamides as potent gamma-secretase inhibitors.
    Prasad CV; Wallace OB; Noonan JW; Sloan CP; Lau W; Vig S; Parker MF; Smith DW; Hansel SB; Polson CT; Barten DM; Felsenstein KM; Roberts SB
    Bioorg Med Chem Lett; 2004 Apr; 14(8):1917-21. PubMed ID: 15050627
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.
    Wu YJ; Zhang Y; Good AC; Burton CR; Toyn JH; Albright CF; Macor JE; Thompson LA
    Bioorg Med Chem Lett; 2009 May; 19(10):2654-60. PubMed ID: 19375914
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to beta-secretase.
    Hu B; Xiong B; Qiu BY; Li X; Yu HP; Xiao K; Wang X; Li J; Shen JK
    Acta Pharmacol Sin; 2006 Dec; 27(12):1586-93. PubMed ID: 17112413
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
    Iserloh U; Wu Y; Cumming JN; Pan J; Wang LY; Stamford AW; Kennedy ME; Kuvelkar R; Chen X; Parker EM; Strickland C; Voigt J
    Bioorg Med Chem Lett; 2008 Jan; 18(1):414-7. PubMed ID: 18023580
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase.
    Hom RK; Fang LY; Mamo S; Tung JS; Guinn AC; Walker DE; Davis DL; Gailunas AF; Thorsett ED; Sinha S; Knops JE; Jewett NE; Anderson JP; John V
    J Med Chem; 2003 May; 46(10):1799-802. PubMed ID: 12723942
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core.
    Björklund C; Adolfsson H; Jansson K; Lindberg J; Vrang L; Hallberg A; Rosenquist S; Samuelsson B
    Bioorg Med Chem; 2010 Feb; 18(4):1711-23. PubMed ID: 20122837
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
    Pietrak BL; Crouthamel MC; Tugusheva K; Lineberger JE; Xu M; DiMuzio JM; Steele T; Espeseth AS; Stachel SJ; Coburn CA; Graham SL; Vacca JP; Shi XP; Simon AJ; Hazuda DJ; Lai MT
    Anal Biochem; 2005 Jul; 342(1):144-51. PubMed ID: 15958191
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.