BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

370 related articles for article (PubMed ID: 16516477)

  • 1. Design, synthesis, and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution.
    Liu F; Qian X; Cui J; Xiao Y; Zhang R; Li G
    Bioorg Med Chem; 2006 Jul; 14(13):4639-44. PubMed ID: 16516477
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: synthesis, cytotoxicity, DNA-binding and cell cycle evaluation.
    Xie L; Xiao Y; Wang F; Xu Y; Qian X; Zhang R; Cui J; Liu J
    Bioorg Med Chem; 2009 Nov; 17(21):7615-21. PubMed ID: 19815418
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: various DNA binding geometry and interesting antitumor capacity.
    Zhang Z; Yang Y; Zhang D; Wang Y; Qian X; Liu F
    Bioorg Med Chem; 2006 Oct; 14(20):6962-70. PubMed ID: 16828559
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents.
    Zhang Z; Jin L; Qian X; Wei M; Wang Y; Wang J; Yang Y; Xu Q; Xu Y; Liu F
    Chembiochem; 2007 Jan; 8(1):113-21. PubMed ID: 17139689
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Acenaphtho[1,2-b]pyrrole-based selective fibroblast growth factor receptors 1 (FGFR1) inhibitors: design, synthesis, and biological activity.
    Chen Z; Wang X; Zhu W; Cao X; Tong L; Li H; Xie H; Xu Y; Tan S; Kuang D; Ding J; Qian X
    J Med Chem; 2011 Jun; 54(11):3732-45. PubMed ID: 21517068
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.
    Song T; Li X; Chang X; Liang X; Zhao Y; Wu G; Xie S; Su P; Wu Z; Feng Y; Zhang Z
    Bioorg Med Chem; 2013 Jan; 21(1):11-20. PubMed ID: 23206987
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies.
    Zhang Z; Wu G; Xie F; Song T; Chang X
    J Med Chem; 2011 Feb; 54(4):1101-5. PubMed ID: 21235240
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine.
    Migawa MT; Drach JC; Townsend LB
    J Med Chem; 2005 Jun; 48(11):3840-51. PubMed ID: 15916436
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
    Mai A; Massa S; Cerbara I; Valente S; Ragno R; Bottoni P; Scatena R; Loidl P; Brosch G
    J Med Chem; 2004 Feb; 47(5):1098-109. PubMed ID: 14971890
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel angular furoquinolinones bearing flexible chain as antitumor agent: design, synthesis, cytotoxic evaluation, and DNA-binding studies.
    Xie L; Qian X; Cui J; Xiao Y; Wang K; Wu P; Cong L
    Bioorg Med Chem; 2008 Sep; 16(18):8713-8. PubMed ID: 18722129
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II.
    Desplat V; Moreau S; Gay A; Fabre SB; Thiolat D; Massip S; Macky G; Godde F; Mossalayi D; Jarry C; Guillon J
    J Enzyme Inhib Med Chem; 2010 Apr; 25(2):204-15. PubMed ID: 20222763
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor.
    Liu Y; Xu Y; Qian X; Xiao Y; Liu J; Shen L; Li J; Zhang Y
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1562-6. PubMed ID: 16403630
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel lipophilic 7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid derivatives as potential antitumor agents: improved synthesis and in vitro evaluation.
    Korolyov A; Dorbes S; Azéma J; Guidetti B; Danel M; Lamoral-Theys D; Gras T; Dubois J; Kiss R; Martino R; Malet-Martino M
    Bioorg Med Chem; 2010 Dec; 18(24):8537-48. PubMed ID: 21067931
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Preparation of pentafluorosulfanyl (SF5) pyrrole carboxylic acid esters.
    Dolbier WR; Zheng Z
    J Org Chem; 2009 Aug; 74(15):5626-8. PubMed ID: 19555094
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines.
    Podeszwa B; Niedbala H; Polanski J; Musiol R; Tabak D; Finster J; Serafin K; Milczarek M; Wietrzyk J; Boryczka S; Mol W; Jampilek J; Dohnal J; Kalinowski DS; Richardson DR
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6138-41. PubMed ID: 17904844
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents.
    Rochais C; Lisowski V; Dallemagne P; Rault S
    Bioorg Med Chem; 2006 Dec; 14(24):8162-75. PubMed ID: 17011196
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and anti-tumor activities of novel methylthio-, sulfinyl-, and sulfonyl-8H-thieno[2,3-b]pyrrolizin-8-oximino derivatives.
    Guo S; Zhao Y; Zhao X; Zhang S; Xie L; Kong W; Gong P
    Arch Pharm (Weinheim); 2007 Aug; 340(8):416-23. PubMed ID: 17628032
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents.
    Gowda NR; Kavitha CV; Chiruvella KK; Joy O; Rangappa KS; Raghavan SC
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4594-600. PubMed ID: 19616939
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel class of positive allosteric modulators of AMPA receptors: design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346.
    Zarrinmayeh H; Tromiczak E; Zimmerman DM; Rankl N; Ho KH; Dominguez E; Castaño A; Escribano A; Fernandez C; Jimenez A; Hornback WJ; Nisenbaum ES
    Bioorg Med Chem Lett; 2006 Oct; 16(19):5203-6. PubMed ID: 16872827
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.
    Deady LW; Rodemann T; Zhuang L; Baguley BC; Denny WA
    J Med Chem; 2003 Mar; 46(6):1049-54. PubMed ID: 12620081
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.