175 related articles for article (PubMed ID: 16527481)
1. Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.
O'Neill PM; Verissimo E; Ward SA; Davies J; Korshin EE; Araujo N; Pugh MD; Cristiano ML; Stocks PA; Bachi MD
Bioorg Med Chem Lett; 2006 Jun; 16(11):2991-5. PubMed ID: 16527481
[TBL] [Abstract][Full Text] [Related]
2. Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology.
Amewu R; Stachulski AV; Berry NG; Ward SA; Davies J; Labat G; Rossignol JF; O'Neill PM
Bioorg Med Chem Lett; 2006 Dec; 16(23):6124-30. PubMed ID: 16978862
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
Amewu R; Gibbons P; Mukhtar A; Stachulski AV; Ward SA; Hall C; Rimmer K; Davies J; Vivas L; Bacsa J; Mercer AE; Nixon G; Stocks PA; O'Neill PM
Org Biomol Chem; 2010 May; 8(9):2068-77. PubMed ID: 20401383
[TBL] [Abstract][Full Text] [Related]
4. Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.
O'Neill PM; Mukhtar A; Ward SA; Bickley JF; Davies J; Bachi MD; Stocks PA
Org Lett; 2004 Sep; 6(18):3035-8. PubMed ID: 15330581
[TBL] [Abstract][Full Text] [Related]
5. Novel endoperoxide antimalarials: synthesis, heme binding, and antimalarial activity.
Taylor DK; Avery TD; Greatrex BW; Tiekink ER; Macreadie IG; Macreadie PI; Humphries AD; Kalkanidis M; Fox EN; Klonis N; Tilley L
J Med Chem; 2004 Mar; 47(7):1833-9. PubMed ID: 15027875
[TBL] [Abstract][Full Text] [Related]
6. Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
Bousejra-El Garah F; Wong MH; Amewu RK; Muangnoicharoen S; Maggs JL; Stigliani JL; Park BK; Chadwick J; Ward SA; O'Neill PM
J Med Chem; 2011 Oct; 54(19):6443-55. PubMed ID: 21888440
[TBL] [Abstract][Full Text] [Related]
7. A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.
Bachi MD; Korshin EE; Hoos R; Szpilman AM; Ploypradith P; Xie S; Shapiro TA; Posner GH
J Med Chem; 2003 Jun; 46(12):2516-33. PubMed ID: 12773055
[TBL] [Abstract][Full Text] [Related]
8. Total syntheses of hexacyclinol, 5-epi-hexacyclinol, and desoxohexacyclinol unveil an antimalarial prodrug motif.
La Clair JJ
Angew Chem Int Ed Engl; 2006 Apr; 45(17):2769-73. PubMed ID: 16470558
[No Abstract] [Full Text] [Related]
9. Synthesis of antimalarial yingzhaosu A analogues by the peroxidation of dienes with Co(II)/O2/Et3SiH.
Tokuyasu T; Kunikawa S; Abe M; Masuyama A; Nojima M; Kim HS; Begum K; Wataya Y
J Org Chem; 2003 Sep; 68(19):7361-7. PubMed ID: 12968887
[TBL] [Abstract][Full Text] [Related]
10. Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
Wang X; Dong Y; Wittlin S; Creek D; Chollet J; Charman SA; Tomas JS; Scheurer C; Snyder C; Vennerstrom JL
J Med Chem; 2007 Nov; 50(23):5840-7. PubMed ID: 17949067
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and in vitro antimalarial activity of sulfone endoperoxides.
Bachi MD; Korshin EE; Ploypradith P; Cumming JN; Xie S; Shapiro TA; Posner GH
Bioorg Med Chem Lett; 1998 Apr; 8(8):903-8. PubMed ID: 9871509
[TBL] [Abstract][Full Text] [Related]
12. Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Ellis GL; Amewu R; Sabbani S; Stocks PA; Shone A; Stanford D; Gibbons P; Davies J; Vivas L; Charnaud S; Bongard E; Hall C; Rimmer K; Lozanom S; Jesús M; Gargallo D; Ward SA; O'Neill PM
J Med Chem; 2008 Apr; 51(7):2170-7. PubMed ID: 18341274
[TBL] [Abstract][Full Text] [Related]
13. Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies.
Najjar F; Gorrichon L; Baltas M; André-Barrès C; Vial H
Org Biomol Chem; 2005 May; 3(9):1612-4. PubMed ID: 15858637
[TBL] [Abstract][Full Text] [Related]
14. Preparation of Antimalarial Endoperoxides by a Formal [2 + 2 + 2] Cycloaddition.
Daeppen C; Kaiser M; Neuburger M; Gademann K
Org Lett; 2015 Nov; 17(21):5420-3. PubMed ID: 26491785
[TBL] [Abstract][Full Text] [Related]
15. Total syntheses of Yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities.
Szpilman AM; Korshin EE; Rozenberg H; Bachi MD
J Org Chem; 2005 Apr; 70(9):3618-32. PubMed ID: 15844999
[TBL] [Abstract][Full Text] [Related]
16. Exploration of a new type of antimalarial compounds based on febrifugine.
Kikuchi H; Yamamoto K; Horoiwa S; Hirai S; Kasahara R; Hariguchi N; Matsumoto M; Oshima Y
J Med Chem; 2006 Jul; 49(15):4698-706. PubMed ID: 16854076
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis and evaluation of 5-substituted amino-2,4-diamino-8-chloropyrimido-[4,5-b]quinolines as novel antimalarials.
Joshi AA; Narkhede SS; Viswanathan CL
Bioorg Med Chem Lett; 2005 Jan; 15(1):73-6. PubMed ID: 15582413
[TBL] [Abstract][Full Text] [Related]
18. Aminocyclopropanes as precursors of endoperoxides with antimalarial activity.
Madelaine C; Buriez O; Crousse B; Florent I; Grellier P; Retailleau P; Six Y
Org Biomol Chem; 2010 Dec; 8(24):5591-601. PubMed ID: 20938514
[TBL] [Abstract][Full Text] [Related]
19. Enhanced antimalarial activity of novel synthetic aculeatin derivatives.
Peuchmaur M; Saïdani N; Botté C; Maréchal E; Vial H; Wong YS
J Med Chem; 2008 Aug; 51(16):4870-3. PubMed ID: 18680278
[TBL] [Abstract][Full Text] [Related]
20. Synthesis, antimalarial activity, structure-activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs.
Barazarte A; Camacho J; Domínguez J; Lobo G; Gamboa N; Rodrigues J; Capparelli MV; Alvarez-Larena A; Andujar S; Enriz D; Charris J
Bioorg Med Chem; 2008 Apr; 16(7):3661-74. PubMed ID: 18314337
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]