124 related articles for article (PubMed ID: 16529930)
1. Identification of an indole series of prostaglandin D2 receptor antagonists.
Sturino CF; Lachance N; Boyd M; Berthelette C; Labelle M; Li L; Roy B; Scheigetz J; Tsou N; Brideau C; Cauchon E; Carriere MC; Denis D; Greig G; Kargman S; Lamontagne S; Mathieu MC; Sawyer N; Slipetz D; O'Neill G; Wang Z; Zamboni R; Metters KM; Young RN
Bioorg Med Chem Lett; 2006 Jun; 16(11):3043-8. PubMed ID: 16529930
[TBL] [Abstract][Full Text] [Related]
2. Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.
Beaulieu C; Guay D; Wang Z; Leblanc Y; Roy P; Dufresne C; Zamboni R; Berthelette C; Day S; Tsou N; Denis D; Greig G; Mathieu MC; O'Neill G
Bioorg Med Chem Lett; 2008 Apr; 18(8):2696-700. PubMed ID: 18359630
[TBL] [Abstract][Full Text] [Related]
3. Azaindoles as potent CRTH2 receptor antagonists.
Simard D; Leblanc Y; Berthelette C; Zaghdane MH; Molinaro C; Wang Z; Gallant M; Lau S; Thao T; Hamel M; Stocco R; Sawyer N; Sillaots S; Gervais F; Houle R; Lévesque JF
Bioorg Med Chem Lett; 2011 Jan; 21(2):841-5. PubMed ID: 21185722
[TBL] [Abstract][Full Text] [Related]
4. Discovery of selective indole-based prostaglandin D₂ receptor antagonist.
Iwahashi M; Shimabukuro A; Onoda T; Matsunaga Y; Okada Y; Matsumoto R; Nambu F; Nakai H; Toda M
Bioorg Med Chem; 2011 Aug; 19(15):4574-88. PubMed ID: 21737285
[TBL] [Abstract][Full Text] [Related]
5. Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.
Johnson MG; Liu JJ; Li AR; van Lengerich B; Wang S; Medina JC; Collins TL; Danao J; Seitz L; Willee A; D'Souza W; Budelsky AL; Fan PW; Wong SG
Bioorg Med Chem Lett; 2014 Jul; 24(13):2877-80. PubMed ID: 24825301
[TBL] [Abstract][Full Text] [Related]
6. Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists.
Torisu K; Kobayashi K; Iwahashi M; Nakai Y; Onoda T; Nagase T; Sugimoto I; Okada Y; Matsumoto R; Nanbu F; Ohuchida S; Nakai H; Toda M
Bioorg Med Chem; 2004 Oct; 12(20):5361-78. PubMed ID: 15388164
[TBL] [Abstract][Full Text] [Related]
7. Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
Sturino CF; O'Neill G; Lachance N; Boyd M; Berthelette C; Labelle M; Li L; Roy B; Scheigetz J; Tsou N; Aubin Y; Bateman KP; Chauret N; Day SH; Lévesque JF; Seto C; Silva JH; Trimble LA; Carriere MC; Denis D; Greig G; Kargman S; Lamontagne S; Mathieu MC; Sawyer N; Slipetz D; Abraham WM; Jones T; McAuliffe M; Piechuta H; Nicoll-Griffith DA; Wang Z; Zamboni R; Young RN; Metters KM
J Med Chem; 2007 Feb; 50(4):794-806. PubMed ID: 17300164
[TBL] [Abstract][Full Text] [Related]
8. 3-Indolyl sultams as selective CRTh2 antagonists.
Tumey LN; Robarge MJ; Gleason E; Song J; Murphy SM; Ekema G; Doucette C; Hanniford D; Palmer M; Pawlowski G; Danzig J; Loftus M; Hunady K; Sherf B; Mays RW; Stricker-Krongrad A; Brunden KR; Bennani YL; Harrington JJ
Bioorg Med Chem Lett; 2010 Jun; 20(11):3287-90. PubMed ID: 20457519
[TBL] [Abstract][Full Text] [Related]
9. A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells.
Oyama S; Fujino H; Yamazaki R; Okura I; Regan JW; Awata A; Arai T; Murayama T
Arch Biochem Biophys; 2014 Jan; 541():21-9. PubMed ID: 24239863
[TBL] [Abstract][Full Text] [Related]
10. Discovery of new orally active prostaglandin D2 receptor antagonists.
Iwahashi M; Naganawa A; Kinoshita A; Shimabukuro A; Nishiyama T; Ogawa S; Matsunaga Y; Tsukamoto K; Okada Y; Matsumoto R; Nambu F; Oumi R; Odagaki Y; Katagi J; Yano K; Tani K; Nakai H; Toda M
Bioorg Med Chem; 2011 Nov; 19(22):6935-48. PubMed ID: 21982795
[TBL] [Abstract][Full Text] [Related]
11. Discovery of new chemical leads for prostaglandin D2 receptor antagonists.
Torisu K; Kobayashi K; Iwahashi M; Egashira H; Nakai Y; Okada Y; Nanbu F; Ohuchida S; Nakai H; Toda M
Bioorg Med Chem Lett; 2004 Sep; 14(17):4557-62. PubMed ID: 15357992
[TBL] [Abstract][Full Text] [Related]
12. Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold.
Valdenaire A; Pothier J; Renneberg D; Riederer MA; Peter O; Leroy X; Gnerre C; Fretz H
Bioorg Med Chem Lett; 2013 Feb; 23(4):944-8. PubMed ID: 23324405
[TBL] [Abstract][Full Text] [Related]
13. Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: lead optimization.
Alonso JA; Andrés M; Bravo M; Calbet M; Eastwood PR; Eichhorn P; Esteve C; Ferrer M; Gómez E; González J; Mir M; Moreno I; Petit S; Roberts RS; Sevilla S; Vidal B; Vidal L; Vilaseca P; Zanuy M
Bioorg Med Chem Lett; 2014 Nov; 24(21):5123-6. PubMed ID: 25437505
[TBL] [Abstract][Full Text] [Related]
14. Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1.
Rist Ø; Grimstrup M; Receveur JM; Frimurer TM; Ulven T; Kostenis E; Högberg T
Bioorg Med Chem Lett; 2010 Feb; 20(3):1177-80. PubMed ID: 20031403
[TBL] [Abstract][Full Text] [Related]
15. Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2.
Yoshimura-Uchiyama C; Iikura M; Yamaguchi M; Nagase H; Ishii A; Matsushima K; Yamamoto K; Shichijo M; Bacon KB; Hirai K
Clin Exp Allergy; 2004 Aug; 34(8):1283-90. PubMed ID: 15298571
[TBL] [Abstract][Full Text] [Related]
16. DP(2) receptor antagonists in development.
Norman P
Expert Opin Investig Drugs; 2010 Aug; 19(8):947-61. PubMed ID: 20615077
[TBL] [Abstract][Full Text] [Related]
17. Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells.
Hirano Y; Shichijo M; Deguchi M; Nagira M; Suzuki N; Nishitani Y; Hattori M; Arimura A
Eur J Pharmacol; 2007 Mar; 560(1):81-8. PubMed ID: 17307163
[TBL] [Abstract][Full Text] [Related]
18. Discovery of orally active prostaglandin D2 receptor antagonists.
Torisu K; Kobayashi K; Iwahashi M; Nakai Y; Onoda T; Nagase T; Sugimoto I; Okada Y; Matsumoto R; Nanbu F; Ohuchida S; Nakai H; Toda M
Bioorg Med Chem Lett; 2004 Oct; 14(19):4891-5. PubMed ID: 15341946
[TBL] [Abstract][Full Text] [Related]
19. Development of prostaglandin D2 receptor antagonist: discovery of highly potent antagonists.
Torisu K; Kobayashi K; Iwahashi M; Nakai Y; Onoda T; Nagase T; Sugimoto I; Okada Y; Matsumoto R; Nanbu F; Ohuchida S; Nakai H; Masaaki Toda
Bioorg Med Chem; 2004 Sep; 12(17):4685-700. PubMed ID: 15358295
[TBL] [Abstract][Full Text] [Related]
20. Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.
Luker T; Bonnert R; Brough S; Cook AR; Dickinson MR; Dougall I; Logan C; Mohammed RT; Paine S; Sanganee HJ; Sargent C; Schmidt JA; Teague S; Thom S
Bioorg Med Chem Lett; 2011 Nov; 21(21):6288-92. PubMed ID: 21944852
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
