These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

278 related articles for article (PubMed ID: 16533711)

  • 1. Role of pharmacologically active metabolites in drug discovery and development.
    Fura A
    Drug Discov Today; 2006 Feb; 11(3-4):133-42. PubMed ID: 16533711
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.
    Fura A; Shu YZ; Zhu M; Hanson RL; Roongta V; Humphreys WG
    J Med Chem; 2004 Aug; 47(18):4339-51. PubMed ID: 15317447
    [No Abstract]   [Full Text] [Related]  

  • 3. Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy.
    Obach RS
    Pharmacol Rev; 2013 Apr; 65(2):578-640. PubMed ID: 23406671
    [TBL] [Abstract][Full Text] [Related]  

  • 4. New horizons in drug metabolism, pharmacokinetics and drug discovery.
    Palmer AM
    Drug News Perspect; 2003; 16(1):57-62. PubMed ID: 12682673
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Strategies for dealing with reactive intermediates in drug discovery and development.
    Nassar AE; Lopez-Anaya A
    Curr Opin Drug Discov Devel; 2004 Jan; 7(1):126-36. PubMed ID: 14982156
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The pivotal role of drug metabolism and pharmacokinetics in the discovery and development of new medicines.
    Alavijeh MS; Palmer AM
    IDrugs; 2004 Aug; 7(8):755-63. PubMed ID: 15334309
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [Strategy of molecular design of drugs: the unification of macro-properties and micro-structures of a molecule].
    Guo ZR
    Yao Xue Xue Bao; 2008 Mar; 43(3):227-33. PubMed ID: 18630256
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Safety assessment of drug metabolites: Characterization of chemically stable metabolites.
    Humphreys WG; Unger SE
    Chem Res Toxicol; 2006 Dec; 19(12):1564-9. PubMed ID: 17173369
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Strategies for dealing with metabolite elucidation in drug discovery and development.
    Nassar AE; Talaat RE
    Drug Discov Today; 2004 Apr; 9(7):317-27. PubMed ID: 15037231
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Drug targeting via retrometabolic approaches.
    Bodor N; Buchwald P
    Pharmacol Ther; 1997; 76(1-3):1-27. PubMed ID: 9535166
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
    Baillie TA
    Chem Res Toxicol; 2008 Jan; 21(1):129-37. PubMed ID: 18052111
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Application of quantitative NMR in pharmacological evaluation of biologically generated metabolites: implications in drug discovery.
    Mutlib A; Espina R; Vishwanathan K; Babalola K; Chen Z; Dehnhardt C; Venkatesan A; Mansour T; Chaudhary I; Talaat R; Scatina J
    Drug Metab Dispos; 2011 Jan; 39(1):106-16. PubMed ID: 20952552
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Application of pharmaceutical profiling assays for optimization of drug-like properties.
    Di L; Kerns EH
    Curr Opin Drug Discov Devel; 2005 Jul; 8(4):495-504. PubMed ID: 16022186
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Quantitative structure-pharmacokinetics relationships and their importance in drug design, possibilities and limitations.
    Seydel JK
    Methods Find Exp Clin Pharmacol; 1984 Oct; 6(10):571-81. PubMed ID: 6513673
    [No Abstract]   [Full Text] [Related]  

  • 15. Drug metabolism for the perplexed medicinal chemist.
    Testa B
    Chem Biodivers; 2009 Nov; 6(11):2055-70. PubMed ID: 19937836
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries.
    Dobson PD; Patel Y; Kell DB
    Drug Discov Today; 2009 Jan; 14(1-2):31-40. PubMed ID: 19049901
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of pharmacokinetics and metabolism in drug discovery and development.
    Lin JH; Lu AY
    Pharmacol Rev; 1997 Dec; 49(4):403-49. PubMed ID: 9443165
    [No Abstract]   [Full Text] [Related]  

  • 18. The pharmacological and toxicological significance of the stereochemistry of drug disposition.
    Caldwell J; Winter SM; Hutt AJ
    Xenobiotica; 1988 Jan; 18 Suppl 1():59-70. PubMed ID: 3344590
    [No Abstract]   [Full Text] [Related]  

  • 19. Classification of metabolites with kernel-partial least squares (K-PLS).
    Embrechts MJ; Ekins S
    Drug Metab Dispos; 2007 Mar; 35(3):325-7. PubMed ID: 17142559
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Complicating factors in safety testing of drug metabolites: kinetic differences between generated and preformed metabolites.
    Prueksaritanont T; Lin JH; Baillie TA
    Toxicol Appl Pharmacol; 2006 Dec; 217(2):143-52. PubMed ID: 17055014
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.