BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

299 related articles for article (PubMed ID: 16536739)

  • 1. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
    Kaether C; Schmitt S; Willem M; Haass C
    Traffic; 2006 Apr; 7(4):408-15. PubMed ID: 16536739
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
    Lewis HD; Pérez Revuelta BI; Nadin A; Neduvelil JG; Harrison T; Pollack SJ; Shearman MS
    Biochemistry; 2003 Jun; 42(24):7580-6. PubMed ID: 12809514
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
    Kume H; Maruyama K; Kametani F
    Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway.
    Goodger ZV; Rajendran L; Trutzel A; Kohli BM; Nitsch RM; Konietzko U
    J Cell Sci; 2009 Oct; 122(Pt 20):3703-14. PubMed ID: 19773363
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Nicastrin binds to membrane-tethered Notch.
    Chen F; Yu G; Arawaka S; Nishimura M; Kawarai T; Yu H; Tandon A; Supala A; Song YQ; Rogaeva E; Milman P; Sato C; Yu C; Janus C; Lee J; Song L; Zhang L; Fraser PE; St George-Hyslop PH
    Nat Cell Biol; 2001 Aug; 3(8):751-4. PubMed ID: 11483961
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
    Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM
    Biochemistry; 1999 Jul; 38(30):9728-34. PubMed ID: 10423252
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.
    Vingtdeux V; Hamdane M; Bégard S; Loyens A; Delacourte A; Beauvillain JC; Buée L; Marambaud P; Sergeant N
    Neurobiol Dis; 2007 Mar; 25(3):686-96. PubMed ID: 17207630
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.
    Lichtenthaler SF; Beher D; Grimm HS; Wang R; Shearman MS; Masters CL; Beyreuther K
    Proc Natl Acad Sci U S A; 2002 Feb; 99(3):1365-70. PubMed ID: 11805291
    [TBL] [Abstract][Full Text] [Related]  

  • 12. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S; Sunyach C; Checler F
    J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Biogenesis and processing of the amyloid precursor protein in the early secretory pathway.
    Selivanova A; Winblad B; Dantuma NP; Farmery MR
    Biochem Biophys Res Commun; 2007 Jun; 357(4):1034-9. PubMed ID: 17466275
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD.
    Gowrishankar K; Zeidler MG; Vincenz C
    J Cell Sci; 2004 Aug; 117(Pt 18):4099-111. PubMed ID: 15280425
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
    Wilson CA; Doms RW; Lee VM
    J Neurosci Res; 2003 Nov; 74(3):361-9. PubMed ID: 14598312
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.
    Fukumori A; Okochi M; Tagami S; Jiang J; Itoh N; Nakayama T; Yanagida K; Ishizuka-Katsura Y; Morihara T; Kamino K; Tanaka T; Kudo T; Tanii H; Ikuta A; Haass C; Takeda M
    Biochemistry; 2006 Apr; 45(15):4907-14. PubMed ID: 16605258
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
    FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.
    Boo JH; Sohn JH; Kim JE; Song H; Mook-Jung I
    Biochem Biophys Res Commun; 2008 Aug; 372(4):913-7. PubMed ID: 18538664
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
    Cupers P; Bentahir M; Craessaerts K; Orlans I; Vanderstichele H; Saftig P; De Strooper B; Annaert W
    J Cell Biol; 2001 Aug; 154(4):731-40. PubMed ID: 11502763
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.