These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
180 related articles for article (PubMed ID: 16566594)
1. Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration. Fernando H; Halpert JR; Davydov DR Biochemistry; 2006 Apr; 45(13):4199-209. PubMed ID: 16566594 [TBL] [Abstract][Full Text] [Related]
2. Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450. Davydov DR; Fernando H; Halpert JR Biophys Chem; 2006 Sep; 123(2-3):95-101. PubMed ID: 16701937 [TBL] [Abstract][Full Text] [Related]
3. Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. Fernando H; Davydov DR; Chin CC; Halpert JR Arch Biochem Biophys; 2007 Apr; 460(1):129-40. PubMed ID: 17274942 [TBL] [Abstract][Full Text] [Related]
4. Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket. Davydov DR; Baas BJ; Sligar SG; Halpert JR Biochemistry; 2007 Jul; 46(26):7852-64. PubMed ID: 17555301 [TBL] [Abstract][Full Text] [Related]
5. Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate. Davydov DR; Kumar S; Halpert JR Biochem Biophys Res Commun; 2002 Jun; 294(4):806-12. PubMed ID: 12061778 [TBL] [Abstract][Full Text] [Related]
6. Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA. Davydov DR; Davydova NY; Halpert JR Biochemistry; 2008 Oct; 47(43):11348-59. PubMed ID: 18831537 [TBL] [Abstract][Full Text] [Related]
7. Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe. Tsalkova TN; Davydova NY; Halpert JR; Davydov DR Biochemistry; 2007 Jan; 46(1):106-19. PubMed ID: 17198380 [TBL] [Abstract][Full Text] [Related]
8. Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site. Dabrowski MJ; Schrag ML; Wienkers LC; Atkins WM J Am Chem Soc; 2002 Oct; 124(40):11866-7. PubMed ID: 12358527 [TBL] [Abstract][Full Text] [Related]
9. Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity. Fernando H; Rumfeldt JA; Davydova NY; Halpert JR; Davydov DR Xenobiotica; 2011 Apr; 41(4):281-9. PubMed ID: 21143007 [TBL] [Abstract][Full Text] [Related]
10. Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET). Davydov DR; Rumfeldt JA; Sineva EV; Fernando H; Davydova NY; Halpert JR J Biol Chem; 2012 Feb; 287(9):6797-809. PubMed ID: 22194603 [TBL] [Abstract][Full Text] [Related]
11. Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe. Davydov DR; Botchkareva AE; Davydova NE; Halpert JR Biophys J; 2005 Jul; 89(1):418-32. PubMed ID: 15834000 [TBL] [Abstract][Full Text] [Related]
12. An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF. Davydov DR; Botchkareva AE; Kumar S; He YQ; Halpert JR Biochemistry; 2004 Jun; 43(21):6475-85. PubMed ID: 15157081 [TBL] [Abstract][Full Text] [Related]
13. Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4. Isin EM; Guengerich FP J Biol Chem; 2006 Apr; 281(14):9127-36. PubMed ID: 16467307 [TBL] [Abstract][Full Text] [Related]
14. Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy. Davydov DR; Halpert JR; Renaud JP; Hui Bon Hoa G Biochem Biophys Res Commun; 2003 Dec; 312(1):121-30. PubMed ID: 14630029 [TBL] [Abstract][Full Text] [Related]
15. Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study. Khan KK; Liu H; Halpert JR Drug Metab Dispos; 2003 Apr; 31(4):356-9. PubMed ID: 12642459 [TBL] [Abstract][Full Text] [Related]
16. The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria. Roberts AG; Campbell AP; Atkins WM Biochemistry; 2005 Feb; 44(4):1353-66. PubMed ID: 15667229 [TBL] [Abstract][Full Text] [Related]
17. Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4. Isin EM; Guengerich FP J Biol Chem; 2007 Mar; 282(9):6863-74. PubMed ID: 17200113 [TBL] [Abstract][Full Text] [Related]
18. Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs: the effect of model membranes. Nath A; Grinkova YV; Sligar SG; Atkins WM J Biol Chem; 2007 Sep; 282(39):28309-28320. PubMed ID: 17573349 [TBL] [Abstract][Full Text] [Related]
19. 7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites. Marsch GA; Carlson BT; Guengerich FP J Biomol Struct Dyn; 2018 Mar; 36(4):841-860. PubMed ID: 28278026 [TBL] [Abstract][Full Text] [Related]
20. N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs. Brandes LJ; Queen GM; LaBella FS Cancer Chemother Pharmacol; 2000; 45(4):298-304. PubMed ID: 10755318 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]