BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

240 related articles for article (PubMed ID: 16570281)

  • 1. Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
    Hein DW; Fretland AJ; Doll MA
    Int J Cancer; 2006 Sep; 119(5):1208-11. PubMed ID: 16570281
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure.
    Hein DW; Salazar-González RA; Doll MA; Zang Y
    Arch Toxicol; 2023 Oct; 97(10):2697-2705. PubMed ID: 37592049
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.
    Fretland AJ; Leff MA; Doll MA; Hein DW
    Pharmacogenetics; 2001 Apr; 11(3):207-15. PubMed ID: 11337936
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.
    Hein DW; Doll MA; Rustan TD; Ferguson RJ
    Cancer Res; 1995 Aug; 55(16):3531-6. PubMed ID: 7627960
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.
    Zang Y; Doll MA; Zhao S; States JC; Hein DW
    Carcinogenesis; 2007 Aug; 28(8):1665-71. PubMed ID: 17434923
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.
    Walraven JM; Zang Y; Trent JO; Hein DW
    Curr Drug Metab; 2008 Jul; 9(6):471-86. PubMed ID: 18680467
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
    Metry KJ; Neale JR; Bendaly J; Smith NB; Pierce WM; Hein DW
    Drug Metab Dispos; 2009 Nov; 37(11):2123-6. PubMed ID: 19666988
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
    Bendaly J; Zhao S; Neale JR; Metry KJ; Doll MA; States JC; Pierce WM; Hein DW
    Cancer Epidemiol Biomarkers Prev; 2007 Jul; 16(7):1503-9. PubMed ID: 17627018
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats.
    Jefferson FA; Xiao GH; Hein DW
    Toxicol Sci; 2009 Jan; 107(1):293-7. PubMed ID: 18842621
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2.
    Metry KJ; Zhao S; Neale JR; Doll MA; States JC; McGregor WG; Pierce WM; Hein DW
    Mol Carcinog; 2007 Jul; 46(7):553-63. PubMed ID: 17295238
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon.
    Turesky RJ; Lang NP; Butler MA; Teitel CH; Kadlubar FF
    Carcinogenesis; 1991 Oct; 12(10):1839-45. PubMed ID: 1934265
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
    Fretland AJ; Devanaboyina US; Doll MA; Zhao S; Xiao GH; Hein DW
    Toxicol Sci; 2003 Aug; 74(2):253-9. PubMed ID: 12773763
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.
    Zhu Y; Doll MA; Hein DW
    Biol Chem; 2002 Jun; 383(6):983-7. PubMed ID: 12222688
    [TBL] [Abstract][Full Text] [Related]  

  • 14. N-Acetyltransferase expression and DNA binding of N-hydroxyheterocyclic amines in human prostate epithelium.
    Wang CY; Debiec-Rychter M; Schut HA; Morse P; Jones RF; Archer C; King CM; Haas GP
    Carcinogenesis; 1999 Aug; 20(8):1591-5. PubMed ID: 10426812
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype.
    Hein DW; Doll MA
    Arch Toxicol; 2017 Aug; 91(8):2827-2835. PubMed ID: 28523442
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interindividual variation in the metabolic activation of heterocyclic amines and their N-hydroxy derivatives in primary cultures of human mammary epithelial cells.
    Stone EM; Williams JA; Grover PL; Gusterson BA; Phillips DH
    Carcinogenesis; 1998 May; 19(5):873-9. PubMed ID: 9635877
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens.
    Hein DW; Doll MA
    Arch Toxicol; 2017 Sep; 91(9):3185-3188. PubMed ID: 28536864
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.
    Hein DW; Doll MA; Rustan TD; Gray K; Feng Y; Ferguson RJ; Grant DM
    Carcinogenesis; 1993 Aug; 14(8):1633-8. PubMed ID: 8353847
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Urinary excretion of unmetabolized and phase II conjugates of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: relationship to cytochrome P4501A2 and N-acetyltransferase activity.
    Stillwell WG; Kidd LC; Wishnok JS; Tannenbaum SR; Sinha R
    Cancer Res; 1997 Aug; 57(16):3457-64. PubMed ID: 9270013
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.
    Gu D; McNaughton L; Lemaster D; Lake BG; Gooderham NJ; Kadlubar FF; Turesky RJ
    Chem Res Toxicol; 2010 Apr; 23(4):788-801. PubMed ID: 20192249
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.