BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

389 related articles for article (PubMed ID: 16571652)

  • 1. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
    Mulligan JM; Greene LM; Cloonan S; Mc Gee MM; Onnis V; Campiani G; Fattorusso C; Lawler M; Williams DC; Zisterer DM
    Mol Pharmacol; 2006 Jul; 70(1):60-70. PubMed ID: 16571652
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
    McElligott AM; Maginn EN; Greene LM; McGuckin S; Hayat A; Browne PV; Butini S; Campiani G; Catherwood MA; Vandenberghe E; Williams DC; Zisterer DM; Lawler M
    Cancer Res; 2009 Nov; 69(21):8366-75. PubMed ID: 19826055
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
    Bright SA; Campiani G; Deininger MW; Lawler M; Williams DC; Zisterer DM
    Biochem Pharmacol; 2010 Jul; 80(1):31-8. PubMed ID: 20206141
    [TBL] [Abstract][Full Text] [Related]  

  • 4. STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.
    Greene LM; Kelly L; Onnis V; Campiani G; Lawler M; Williams DC; Zisterer DM
    J Pharmacol Exp Ther; 2007 Apr; 321(1):288-97. PubMed ID: 17202400
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents.
    Zisterer DM; Campiani G; Nacci V; Williams DC
    J Pharmacol Exp Ther; 2000 Apr; 293(1):48-59. PubMed ID: 10734152
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
    Nathwani SM; Butler S; Meegan MJ; Campiani G; Lawler M; Williams DC; Zisterer DM
    Cancer Chemother Pharmacol; 2010 Jan; 65(2):289-300. PubMed ID: 19479253
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL.
    Mc Gee MM; Greene LM; Ledwidge S; Campiani G; Nacci V; Lawler M; Williams DC; Zisterer DM
    J Pharmacol Exp Ther; 2004 Sep; 310(3):1084-95. PubMed ID: 15143129
    [TBL] [Abstract][Full Text] [Related]  

  • 8. BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines.
    Greene LM; Campiani G; Lawler M; Williams DC; Zisterer DM
    Mol Pharmacol; 2008 Feb; 73(2):419-30. PubMed ID: 17991869
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.
    Bright SA; Greene LM; Greene TF; Campiani G; Butini S; Brindisi M; Lawler M; Meegan MJ; Williams DC; Zisterer DM
    Biochem Pharmacol; 2009 Feb; 77(3):310-21. PubMed ID: 19014913
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.
    Nathwani SM; Butler S; Fayne D; McGovern NN; Sarkadi B; Meegan MJ; Lloyd DG; Campiani G; Lawler M; Williams DC; Zisterer DM
    Cancer Chemother Pharmacol; 2010 Aug; 66(3):585-96. PubMed ID: 20020128
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.
    Greene LM; Fleeton M; Mulligan J; Gowda C; Sheahan BJ; Atkins GJ; Campiani G; Nacci V; Lawler M; Williams DC; Zisterer DM
    Oncol Rep; 2005 Nov; 14(5):1357-63. PubMed ID: 16211309
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors.
    Tahir SK; Han EK; Credo B; Jae HS; Pietenpol JA; Scatena CD; Wu-Wong JR; Frost D; Sham H; Rosenberg SH; Ng SC
    Cancer Res; 2001 Jul; 61(14):5480-5. PubMed ID: 11454695
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
    Nathwani SM; Cloonan SM; Stronach M; Campiani G; Lawler M; Williams DC; Zisterer DM
    Oncol Rep; 2010 Dec; 24(6):1499-507. PubMed ID: 21042745
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.
    Wong VK; Chiu P; Chung SS; Chow LM; Zhao YZ; Yang BB; Ko BC
    Clin Cancer Res; 2005 Aug; 11(16):6002-11. PubMed ID: 16115945
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 3-(Iodoacetamido)-benzoylurea: a novel cancericidal tubulin ligand that inhibits microtubule polymerization, phosphorylates bcl-2, and induces apoptosis in tumor cells.
    Jiang JD; Davis AS; Middleton K; Ling YH; Perez-Soler R; Holland JF; Bekesi JG
    Cancer Res; 1998 Dec; 58(23):5389-95. PubMed ID: 9850070
    [TBL] [Abstract][Full Text] [Related]  

  • 16. BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
    Kuo CC; Hsieh HP; Pan WY; Chen CP; Liou JP; Lee SJ; Chang YL; Chen LT; Chen CT; Chang JY
    Cancer Res; 2004 Jul; 64(13):4621-8. PubMed ID: 15231674
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
    Lennon JC; Bright SA; Carroll E; Butini S; Campiani G; O'Meara A; Williams DC; Zisterer DM
    Biochem Pharmacol; 2014 Feb; 87(4):611-24. PubMed ID: 24406249
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells.
    Liao CH; Pan SL; Guh JH; Teng CM
    Biochem Pharmacol; 2004 Jun; 67(11):2031-8. PubMed ID: 15135300
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.
    Chen YC; Lu PH; Pan SL; Teng CM; Kuo SC; Lin TP; Ho YF; Huang YC; Guh JH
    Biochem Pharmacol; 2007 Jun; 74(1):10-9. PubMed ID: 17475221
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
    Verma NK; Dempsey E; Conroy J; Olwell P; Mcelligott AM; Davies AM; Kelleher D; Butini S; Campiani G; Williams DC; Zisterer DM; Lawler M; Volkov Y
    J Mol Med (Berl); 2008 Apr; 86(4):457-69. PubMed ID: 18270678
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.