BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

161 related articles for article (PubMed ID: 16580199)

  • 1. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.
    Patch RJ; Baumann CA; Liu J; Gibbs AC; Ott H; Lattanze J; Player MR
    Bioorg Med Chem Lett; 2006 Jun; 16(12):3282-6. PubMed ID: 16580199
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
    Hsu JT; Yeh TK; Yen SC; Chen CT; Hsieh SY; Hsu T; Lu CT; Chen CH; Chou LH; Chiu CH; Chang YI; Tseng YJ; Yen KR; Chao YS; Lin WH; Jiaang WT
    Bioorg Med Chem Lett; 2012 Jul; 22(14):4654-9. PubMed ID: 22726931
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
    DiMauro EF; Newcomb J; Nunes JJ; Bemis JE; Boucher C; Chai L; Chaffee SC; Deak HL; Epstein LF; Faust T; Gallant P; Gore A; Gu Y; Henkle B; Hsieh F; Huang X; Kim JL; Lee JH; Martin MW; McGowan DC; Metz D; Mohn D; Morgenstern KA; Oliveira-dos-Santos A; Patel VF; Powers D; Rose PE; Schneider S; Tomlinson SA; Tudor YY; Turci SM; Welcher AA; Zhao H; Zhu L; Zhu X
    J Med Chem; 2008 Mar; 51(6):1681-94. PubMed ID: 18321037
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents.
    Patch RJ; Brandt BM; Asgari D; Baindur N; Chadha NK; Georgiadis T; Cheung WS; Petrounia IP; Donatelli RR; Chaikin MA; Player MR
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6070-4. PubMed ID: 17904845
    [TBL] [Abstract][Full Text] [Related]  

  • 5. FLT3 inhibitor KRN383 on xenografted human leukemic cells harboring FLT3-activating mutations FLT3 in AML: much more to learn about biology and optimal targeting.
    Giles FJ
    Leuk Res; 2006 Dec; 30(12):1469-70. PubMed ID: 16631251
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of quinolinone derivatives as potent FLT3 inhibitors.
    Chung HJ; Kamli MR; Lee HJ; Ha JD; Cho SY; Lee J; Kong JY; Han SY
    Biochem Biophys Res Commun; 2014 Mar; 445(3):561-5. PubMed ID: 24530392
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Quantifying the structural requirements for designing newer FLT3 inhibitors.
    Kar RK; Suryadevara P; Roushan R; Sahoo GC; Dikhit MR; Das P
    Med Chem; 2012 Sep; 8(5):913-27. PubMed ID: 22741797
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.
    Chao Q; Sprankle KG; Grotzfeld RM; Lai AG; Carter TA; Velasco AM; Gunawardane RN; Cramer MD; Gardner MF; James J; Zarrinkar PP; Patel HK; Bhagwat SS
    J Med Chem; 2009 Dec; 52(23):7808-16. PubMed ID: 19754199
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Taking quinazoline as a general support-Nog to design potent and selective kinase inhibitors: application to FMS-like tyrosine kinase 3.
    Li WW; Chen JJ; Zheng RL; Zhang WQ; Cao ZX; Yang LL; Qing XY; Zhou LX; Yang L; Yu LD; Chen LJ; Wei YQ; Yang SY
    ChemMedChem; 2010 Apr; 5(4):513-6. PubMed ID: 20140937
    [No Abstract]   [Full Text] [Related]  

  • 10. Facile identification of dual FLT3-Aurora A inhibitors: a computer-guided drug design approach.
    Chang Hsu Y; Ke YY; Shiao HY; Lee CC; Lin WH; Chen CH; Yen KJ; Hsu JT; Chang C; Hsieh HP
    ChemMedChem; 2014 May; 9(5):953-61. PubMed ID: 24665000
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
    Chin YW; Kong JY; Han SY
    Bioorg Med Chem Lett; 2013 Mar; 23(6):1768-70. PubMed ID: 23411073
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
    Lin WH; Hsu JT; Hsieh SY; Chen CT; Song JS; Yen SC; Hsu T; Lu CT; Chen CH; Chou LH; Yang YN; Chiu CH; Chen CP; Tseng YJ; Yen KJ; Yeh CF; Chao YS; Yeh TK; Jiaang WT
    Bioorg Med Chem; 2013 Jun; 21(11):2856-67. PubMed ID: 23618709
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency.
    Anderson DR; Meyers MJ; Kurumbail RG; Caspers N; Poda GI; Long SA; Pierce BS; Mahoney MW; Mourey RJ
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4878-81. PubMed ID: 19616945
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties.
    Rheault TR; Donaldson KH; Badiang-Alberti JG; Davis-Ward RG; Andrews CW; Bambal R; Jackson JR; Cheung M
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4587-92. PubMed ID: 20594842
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides.
    Han SY; Chin YW
    J Enzyme Inhib Med Chem; 2011 Jun; 26(3):445-8. PubMed ID: 20846091
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amide-based inhibitors of p38alpha MAP kinase. Part 1: discovery of novel N-pyridyl amide lead molecules.
    Luedtke GR; Schinzel K; Tan X; Tester RW; Nashashibi I; Xu YJ; Dugar S; Levy DE; Jung J
    Bioorg Med Chem Lett; 2010 Apr; 20(8):2556-9. PubMed ID: 20346653
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
    Angell RM; Bamborough P; Cleasby A; Cockerill SG; Jones KL; Mooney CJ; Somers DO; Walker AL
    Bioorg Med Chem Lett; 2008 Jan; 18(1):318-23. PubMed ID: 18006306
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of 6-phenylimidazo[2,1-b]thiazole derivatives as a new type of FLT3 inhibitors.
    Lin XD; Yang HW; Ma S; Li WW; Zhang CH; Wang WJ; Xiang R; Li LL; Yang SY
    Bioorg Med Chem Lett; 2015 Oct; 25(20):4534-8. PubMed ID: 26342867
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.
    Angell RM; Angell TD; Bamborough P; Brown D; Brown M; Buckton JB; Cockerill SG; Edwards CD; Jones KL; Longstaff T; Smee PA; Smith KJ; Somers DO; Walker AL; Willson M
    Bioorg Med Chem Lett; 2008 Jan; 18(1):324-8. PubMed ID: 17981461
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors.
    Gaul MD; Xu G; Kirkpatrick J; Ott H; Baumann CA
    Bioorg Med Chem Lett; 2007 Sep; 17(17):4861-5. PubMed ID: 17611106
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.