BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

180 related articles for article (PubMed ID: 16606360)

  • 1. Neprilysin activity and expression are controlled by nicastrin.
    Pardossi-Piquard R; Dunys J; Yu G; St George-Hyslop P; Alves da Costa C; Checler F
    J Neurochem; 2006 May; 97(4):1052-6. PubMed ID: 16606360
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
    Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
    Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
    Walker ES; Martinez M; Wang J; Goate A
    J Neurochem; 2006 Jul; 98(1):300-9. PubMed ID: 16805816
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.
    Alves da Costa C; Ayral E; Hernandez JF; St George-Hyslop P; Checler F
    J Neurochem; 2004 Aug; 90(4):800-6. PubMed ID: 15287885
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
    Edbauer D; Winkler E; Haass C; Steiner H
    Proc Natl Acad Sci U S A; 2002 Jun; 99(13):8666-71. PubMed ID: 12048259
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nicastrin binds to membrane-tethered Notch.
    Chen F; Yu G; Arawaka S; Nishimura M; Kawarai T; Yu H; Tandon A; Supala A; Song YQ; Rogaeva E; Milman P; Sato C; Yu C; Janus C; Lee J; Song L; Zhang L; Fraser PE; St George-Hyslop PH
    Nat Cell Biol; 2001 Aug; 3(8):751-4. PubMed ID: 11483961
    [TBL] [Abstract][Full Text] [Related]  

  • 10. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
    J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Reconstitution of gamma-secretase activity.
    Edbauer D; Winkler E; Regula JT; Pesold B; Steiner H; Haass C
    Nat Cell Biol; 2003 May; 5(5):486-8. PubMed ID: 12679784
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
    Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
    J Neurochem; 2004 Apr; 89(1):44-53. PubMed ID: 15030388
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
    Li T; Ma G; Cai H; Price DL; Wong PC
    J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
    Siman R; Salidas S
    Neuroscience; 2004; 129(3):615-28. PubMed ID: 15541883
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
    Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.
    Brunkan AL; Martinez M; Wang J; Walker ES; Beher D; Shearman MS; Goate AM
    J Neurochem; 2005 Sep; 94(5):1315-28. PubMed ID: 16001967
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A; Uemura K; Kitagawa N; Aoyagi N; Kihara T; Ninomiya H; Ishiura S; Takahashi R; Shimohama S
    J Neurosci Res; 2007 Jan; 85(1):153-65. PubMed ID: 17075903
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metabolic regulation of brain Abeta by neprilysin.
    Iwata N; Tsubuki S; Takaki Y; Shirotani K; Lu B; Gerard NP; Gerard C; Hama E; Lee HJ; Saido TC
    Science; 2001 May; 292(5521):1550-2. PubMed ID: 11375493
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.